Results 61 to 70 of about 2,900,874 (198)

An epigenetic mechanism of azole tolerance facilitates acquired antifungal resistance in Aspergillus fumigatus

mBio
Antibiotic tolerance paves the way for acquired resistance in bacterial pathogens. However, the mechanisms of tolerance and its evolutionary role in acquired resistance in pathogenic fungi, and particularly in filamentous fungi, remain elusive.
Sandeep Vellanki, Nathan DeMichaelis, Catherine Liao, Jason E. Stajich, Robert A. Cramer   +4 more
doaj   +1 more source

Early drug effects signal subsequent drug effects: Intra-administration associations and the conditioning analysis of tolerance

, 2000
The Pavlovian conditioning analysis of drug tolerance emphasizes that cues present at the time of drug administration become associated with drug-induced disturbances.
Kim, Andrew Joseph
core   +1 more source

Chromametric assessment of drug skin tolerance: A comparative study between Africans and Caucasians skins.

, 2020
BACKGROUND/AIMS: During dermatological forms development, one of the simplest non-invasive techniques used to evaluate cutaneous tolerance of formulations is to monitor the color changes using a tristimulus chromameter.
Piel, Géraldine, Joëlle Quetin‐Leclercq, Géraldine Piel, Donneau, Anne-Françoise, Evrard, Brigitte, Fernand Gbaguidi, Lechanteur, Anna, Quetin-Leclercq, Joëlle, Anna Lechanteur, Anne‐Françoise Donneau, Hope T. Sounouvou, Gbaguidi, Fernand, Brigitte Evrard, Sounouvou, Hope T   +13 more
core   +1 more source

Tolerance to coxibs in patients with intolerance to non-steroidal anti-inflammatory drugs (NSAIDs) : a systematic structured review of the literature [PDF]

, 2007
Adverse events triggered by non-steroidal anti-inflammatory drugs (NSAIDs) are among the most common drug-related intolerance reactions in medicine; they are possibly related to inhibition of cyclooxygenase-1.
Weberschock, Tobias Bernd Bernd, Boehncke, Wolf-Henning, Tobias Bernd Weberschock, Sylke-Monina Müller, Sandra Boehncke, Müller, Sylke-Monina, Wolf-Henning Boehncke, Weberschock, Tobias Bernd, Boehncke, Sandra   +8 more
core   +1 more source

Western Hemisphere Drug Policy Commission [website]

, 2021
Website of the Western Hemisphere Drug Policy Commission (WHDPC), charged to "evaluate a range of US counternarcotics programs in the Americas and then make recommendations to improve them" -- including a recording and transcript of the group's hearing ...
United States. Western Hemisphere Drug Policy Commission.
core  

Parameters affecting the reliable measurement of fluconazole tolerance using disk diffusion assays with Candida albicans

Microbiology Spectrum
Disk diffusion assays (DDAs) are widely used to determine antimicrobial susceptibility, which is measured as the size of the zone of inhibition (ZOI) after 24 h of growth, and is inversely proportional to the minimal inhibitory concentration (MIC).
Nora Kawar, Judith Berman
doaj   +1 more source

Drug-Induced Epigenetic Changes Produce Drug Tolerance

PLoS Biology, 2007
Tolerance to drugs that affect neural activity is mediated, in part, by adaptive mechanisms that attempt to restore normal neural excitability. Changes in the expression of ion channel genes are thought to play an important role in these neural adaptations.
Wang, Yan, Krishnan, Harish R, Ghezzi, Alfredo, Yin, Jerry C. P, Atkinson, Nigel S.   +4 more
openaire   +5 more sources

Drug tolerance in Mycobacterium tuberculosis

, 2018
Although Mycobacterium tuberculosis is eradicated rapidly during therapy in some patients with pulmonary tuberculosis, it can persist for many months in others. This study examined the relationship between mycobacterial drug tolerance (delayed killing in
전선희
core   +1 more source

Optimizing targeted therapy for metastatic melanoma: a combination of encorafenib and trametinib beyond standard protocols

Dermatology Reports
Only three combinations of BRAF inhibitor (BRAFi) and MEK inhibitor (MEKi) targeted therapies are marketed for the treatment of BRAF-mutated metastatic melanoma. The use of these combinations can be limited by the occurrence of severe adverse events (AEs)
François Pélouard, Valérie Chedru-Legros, Catherine Nganoa, Anne Dompmartin, Jean-Matthieu L'Orphelin   +4 more
doaj   +1 more source

NLRP3 inflammasome: a key driver of neuroinflammation and a novel therapeutic target for neuropathic pain [PDF]

Anesthesia and Pain Medicine
Neuropathic pain represents a serious complication arising from a spectrum of disorders that precipitate lesions within the central and peripheral nervous systems. This disabling pain can persist for years, severely diminishing the quality of life of the
Zana Montazeri-Khosh, Ahmad Ebrahimpour, Mahyar Hossein-Zargari, Parsa Taghizadeh-Tabrizi, Mohammad Safari-Sahlabadi, Mohammad Hosein Sheybani-Arani, Nahid Davoodian   +6 more
doaj   +1 more source