Results 61 to 70 of about 411,089 (301)

_M. tuberculosis_ interactome analysis unravels potential pathways to drug resistance [PDF]

, 2008
Drug resistance is a major problem for combating tuberculosis. Lack of understanding of how resistance emerges in bacteria upon drug treatment limits our ability to counter resistance.
Nagasuma Chandra, Karthik Raman
core   +1 more source

Epigenetic blind spots – the role of DNA methylation dynamics in stem cell‐based models of embryogenesis

FEBS Letters, EarlyView.
Embryo‐like structures (stembryos) are an innovative tool, but they are hindered by experimental variability and limited developmental potential. DNA methylation is crucial for mammalian development, but its status in stembryo models is poorly characterized.
Sara Canil, Anna Corrà, Annalisa Scapolatiello, Chengxiang Qiu, Gianluca Amadei   +4 more
wiley   +1 more source

mGluR5 Negative Modulators for Fragile X: Treatment Resistance and Persistence

Frontiers in Psychiatry, 2021
Fragile X syndrome (FXS) is caused by silencing of the human FMR1 gene and is the leading monogenic cause of intellectual disability and autism. Abundant preclinical data indicated that negative allosteric modulators (NAMs) of metabotropic glutamate ...
David C. Stoppel, Patrick K. McCamphill, Rebecca K. Senter, Arnold J. Heynen, Mark F. Bear   +4 more
doaj   +1 more source

Conserved binding mode but diverse interfaces of MreC‐PBP2 interactions

FEBS Letters, EarlyView.
The crystal structure of abMreC reveals a conserved two β‐barrel architecture and provides structural insights into its role within the bacterial elongasome. The abMreC–abPBP2 complex model identifies the molecular basis of MreC‐mediated PBP2 recognition, contributing to the regulation of peptidoglycan synthesis.
Hyunseok Jang, Hyo Been Jin, Chang Min Kim, So Yeon Lee, Hyun Ho Park   +4 more
wiley   +1 more source

The relation between drug exposure and tolerance: contingent drug tolerance reexamined [PDF]

, 1994
The finding that the performance of a response during periods of drug exposure facilitates the development of tolerance to the effects of the drug on that response is commonly referred to as contingent drug tolerance.
Kippin, Tod Edward
core  

Progress in the study of autophagy-related proteins affecting resistance to chemotherapeutic drugs in leukemia

Frontiers in Cell and Developmental Biology
Leukemia is a life-threatening malignant tumor of the hematopoietic system. Currently, the main treatment modalities are chemotherapy and hematopoietic stem cell transplantation. However, increased drug resistance due to decreased sensitivity of leukemia
Meng Li, Jing Li, Shiming Zhang, Linghan Zhou, Yuanyuan Zhu, Shen Li, Qiong Li, Junjie Wang, Ruipeng Song   +8 more
doaj   +1 more source

Drug Tolerance in Mycobacterium tuberculosis [PDF]

Antimicrobial Agents and Chemotherapy, 1999
ABSTRACT Although Mycobacterium tuberculosis is eradicated rapidly during therapy in some patients with pulmonary tuberculosis, it can persist for many months in others. This study examined the relationship between mycobacterial drug tolerance (delayed killing in vitro), persistence, and relapse.
R S, Wallis, S, Patil, S H, Cheon, K, Edmonds, M, Phillips, M D, Perkins, M, Joloba, A, Namale, J L, Johnson, L, Teixeira, R, Dietze, S, Siddiqi, R D, Mugerwa, K, Eisenach, J J, Ellner   +14 more
openaire   +2 more sources

Keratin 19 as a prognostic marker and contributing factor of metastasis and chemoresistance in high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch, Isabel Vogel, Sina Nokodian, Johanna Moeller, Antonia Blechschmidt, Vicky Hecht, Vanessa Kuentzel, Katharina Thiedig, Melissa Schwab, Oliver Schilling, Holger Bronger, Marion Kiechle, Viktor Magdolen, Tobias Dreyer   +13 more
wiley   +1 more source

Distinct histone modifications denote early stress-induced drug tolerance in cancer [PDF]

, 2017
Besides somatic mutations or drug efflux, epigenetic reprogramming can lead to acquired drug resistance. We recently have identified early stress-induced multi-drug tolerant cancer cells termed induced drug-tolerant cells (IDTCs).
Dinoop Ravindran Menon, Torrano, Joachim, Brafford, Patricia, Dave S. B. Hoon, Gabrielli, B, Hammerlindl, Heinz, Hammerlindl, H, Gordon B. Mills, Salomon, MP, Joachim Torrano, Flaherty, K, Patricia Brafford, Hammerlindl, S, Mills, Gordon B., Herlyn, Meenhard, Sabrina Hammerlindl, Heinz Hammerlindl, Stark, MS, Marzese, Diego M., Lu, Yiling, Flaherty, Keith, Emran, Abdullah Al, Dave, SBH, Herlyn, M, Richard A. Sturm, Helmut Schaider, Keith Flaherty, Gupta, D, Mills, GB, Gao Zhang, Schaider, H, Hoon, Dave S. B., Schaider, Helmut, Salomon, Matthew P., Brian Gabrielli, Nellie Nelson, Yiling Lu, Diego M. Marzese, Stark, Mitchell S., Torrano, J, Meenhard Herlyn, Al Emran, Abdullah, Matthew P. Salomon, Nelson, N, Marzese, DM, Gabrielli, Brian, Brafford, P, Zhang, Gao, Emran, AA, Menon, Dinoop Ravindran, Nelson, Nellie, Menon, DR, Zhang, G, Gupta, Deepesh, Deepesh Gupta, Dave, S. B.Hoon, Sturm, Richard A., Lu, Y, Mitchell S. Stark, Sturm, RA, Hammerlindl, Sabrina, Abdullah Al Emran   +61 more
core   +1 more source

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source