Nature Communications, 2020 The determination of individual cell trajectories through a high-dimensional cell-state space is an outstanding challenge for understanding biological changes ranging from cellular differentiation to epigenetic responses of diseased cells upon drugging ...
Yapeng Su +22 more
semanticscholar +1 more source
Microorganisms, 2023 Antibiotics have played a crucial role in the reduction in the incidence of TB globally as evidenced by the fact that before the mid-20th century, the mortality rate within five years of the onset of the disease was 50%.
Giuseppe Mancuso +4 more
doaj +1 more source
Equine or porcine synovial fluid as a novel ex vivo model for the study of bacterial free-floating biofilms that form in human joint infections [PDF]
, 2019 Bacterial invasion of synovial joints, as in infectious or septic arthritis, can be difficult to treat in both veterinary and human clinical practice.
Conlon, Brian P. +7 more
core +2 more sources
Drug Dependence: Drug Addiction, Drug Abuse, Drug Tolerance and Dependence
International Journal of Advanced Research in Science, Communication and Technology, 2023 Dependence means that when a person stops using a drug, their body goes through “withdrawal”: a group of physical and mental symptoms that can range from mild (if the drug is caffeine) to life-threatening (such as alcohol or opioids, including heroin and prescription pain relievers).
null Mrudula Shrikrishna Pachpande +1 more
openaire +1 more source
Metabolic and cardiac adaptation to chronic pharmacologic blockade of facilitative glucose transport in murine dilated cardiomyopathy and myocardial ischemia [PDF]
, 2018 GLUT transgenic and knockout mice have provided valuable insight into the role of facilitative glucose transporters (GLUTs) in cardiovascular and metabolic disease, but compensatory physiological changes can hinder interpretation of these models.
Heitmeier, Monique R. +6 more
core +2 more sources
Actionable mechanisms of drug tolerance and resistance in Mycobacterium tuberculosis
The FEBS JournalThe emergence of antimicrobial resistance (AMR) across bacterial pathogens presents a serious threat to global health. This threat is further exacerbated in tuberculosis (TB), mainly due to a protracted treatment regimen involving a combination of drugs.
Dipanwita Datta +4 more
semanticscholar +1 more source
Drug tolerance to target therapy in melanoma revealed at single cell level: What next?
Biochimica et biophysica acta. Reviews on cancer, 2020 Drug resistance strongly impairs the efficacy of virtually every kind of anticancer therapy. This phenomenon is commonly fueled by intrinsic or acquired mechanisms.
D. Liguoro +3 more
semanticscholar +1 more source
Drug-Induced Epigenetic Changes Produce Drug Tolerance
PLoS Biology, 2007 Tolerance to drugs that affect neural activity is mediated, in part, by adaptive mechanisms that attempt to restore normal neural excitability. Changes in the expression of ion channel genes are thought to play an important role in these neural adaptations.
Wang, Yan +4 more
openaire +5 more sources
Weaning of immunosuppression in long - Term liver transplant recipients [PDF]
, 1995 Seventy-two long-surviving liver transplant recipients were evaluated prospectively, including a baseline allograft biopsy for weaning off of immunosuppression.
Abu-Elmagd, K +11 more
core +1 more source
Phase variation in Mycobacterium tuberculosis glpK produces transiently heritable drug tolerance
Proceedings of the National Academy of Sciences of the United States of America, 2019 Significance The ability of Mycobacterium tuberculosis to survive during prolonged treatment has been attributed to either transient stress responses or fixed heritable drug-resistance–producing mutations.
H. Safi +16 more
semanticscholar +1 more source