Results 81 to 90 of about 5,956,077 (339)

Glutathione Peroxidase 4 as a Therapeutic Target for Anti-Colorectal Cancer Drug-Tolerant Persister Cells

Frontiers in Oncology, 2022
BackgroundDespite the effectiveness of chemotherapy and targeted therapy for colorectal cancer, drug resistance drives therapy failure and tumor relapse.
Xiaoli Zhang, Xiaoli Zhang, Xiaoli Zhang, Yiming Ma, Jianhui Ma, Lan Yang, Qingzhi Song, Hongying Wang, Guoqing Lv   +8 more
doaj   +1 more source

Employee involvement in and perceptions of campus alcohol and drug abuse prevention programming at UW-Stout [PDF]

, 1999
Plan BNational research has continually shown that college campuses nationwide foster many alcohol and drug use behaviors. It is suggested that faculty and staff may hold several misperceptions in regard to the prevalence and nature of the alcohol and ...
Mishacoff, Natascha L.
core  

Methadone tolerance testing in drug misusers [PDF]

BMJ, 2006
Asking drug misusers the dose they need for methadone maintenance might seem like an invitation to exaggerate, but experience in one practice suggests that it could improve uptake of treatment without compromising ...
Adam, Bakker, Cindy, Fazey
openaire   +2 more sources

Outcomes of Live Virus Vaccination in Patients With Vascular Anomalies Being Treated With Sirolimus

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background Live vaccination in patients with vascular anomalies (VA) receiving sirolimus remains controversial due to immunosuppressive effects and theoretical risks. Procedure This single‐center retrospective study included patients with VA less than 4 years old at the start of sirolimus therapy who were incompletely vaccinated.
Svatava Merkle, Kiersten Ricci, Kelly Blache, Rebecca A. Marsh, Adrienne M. Hammill, Elissa Engel   +5 more
wiley   +1 more source

Characterizing clinical isolates of Acanthamoeba castellanii with high resistance to polyhexamethylene biguanide in Taiwan

Journal of Microbiology, Immunology and Infection, 2017
Background/Purpose: Acanthamoeba keratitis (AK), a painful infectious corneal disease, is caused by the free-living pathogenic species Acanthamoeba. The symptoms include corneal infiltrate, epithelial, and stromal destruction, and loss of vision. Current
Fu-Chin Huang, Min-Hsiu Shih, Kai-Fei Chang, Jian-Ming Huang, Jyh-Wei Shin, Wei-Chen Lin   +5 more
doaj   +1 more source

Lung cancer cells survive epidermal growth factor receptor tyrosine kinase inhibitor exposure through upregulation of cholesterol synthesis

FASEB BioAdvances, 2020
Epidermal growth factor receptor (EGFR) tyrosine kinase inhibitors (TKIs) provide clinical benefits over chemotherapy for lung cancer patients with EGFR activating mutations.
Mark C. Howell, Ryan Green, Roukiah Khalil, Elspeth Foran, Waise Quarni, Rajesh Nair, Stanley Stevens, Aleksandr Grinchuk, Andrew Hanna, Shyam Mohapatra, Subhra Mohapatra   +10 more
doaj   +1 more source

Persister cells as a possible cause of antibiotic therapy failure in Helicobacter pylori

JGH Open, 2021
Background and Aim Due to the failure of antibiotic treatment and recurrence of infection in patients with Helicobacter pylori, this study was designed to find the possible cause of treatment failure and recurrence of the H.
Parvin Bahmaninejad, Sobhan Ghafourian, Mina Mahmoudi, Abbas Maleki, Nourkhoda Sadeghifard, Behzad Badakhsh   +5 more
doaj   +1 more source

The challenge of perioperative pain management in opioid-tolerant patients [PDF]

, 2017
The increasing number of opioid users among chronic pain patients, and opioid abusers among the general population, makes perioperative pain management challenging for health care professionals.
Bifulco, F, Coluzzi, Flaminia, Corcione, A., Cuomo, A, Dauri, M, Leonardi, C, Melotti, Rm, Natoli, S, Romualdi, P, Savoia, G   +9 more
core   +2 more sources

Feasibility and Safety of High‐Dose Proton Re‐Irradiation in Recurrent Pediatric Central Nervous System Tumors: A Single‐Institution Retrospective Study

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Purpose Pediatric central nervous system (CNS) tumors often recur despite multimodality therapy. Although re‐irradiation (re‐RT) has historically been limited by concerns for severe late toxicities, modern techniques have renewed interest in this approach. Proton therapy provides dosimetric advantages that may enable curative re‐treatment with
Jin‐Ho Song, Jonathan Baron, Carlos Chavez Perez, Sidharth Ramesh, Jane Minturn, Kavita A. Desai, Amish C. Shah, Jean M. Belasco, Kristina A. Cole, Michael J. Fisher, Phillip B. Storm, Peter M. Madsen, Goldie Kurtz, Robert A. Lustig, Christine Hill‐Kayser, Michael J. LaRiviere   +15 more
wiley   +1 more source

Targeting redox heterogeneity to counteract drug tolerance in replicating Mycobacterium tuberculosis

Science Translational Medicine, 2019
Chloroquine resets the redox physiology of Mycobacterium tuberculosis to potentiate the efficacy of antibiotics in vivo. Antibiotic redox-based redux Phagosomal pH and redox heterogeneity in Mycobacterium tuberculosis (Mtb) can promote tolerance of the ...
Richa Mishra, S. Kohli, Nitish Malhotra, Parijat Bandyopadhyay, Mansi Mehta, MohamedHusen Munshi, Vasista Adiga, V. K. Ahuja, R. Shandil, R. S. Rajmani, A. Seshasayee, Amit Singh   +11 more
semanticscholar   +1 more source