Results 101 to 110 of about 5,956,077 (339)

Drug-Tolerant Idling Melanoma Cells Exhibit Theory-Predicted Metabolic Low-Low Phenotype

Frontiers in Oncology, 2020
Cancer cells adjust their metabolic profiles to evade treatment. Metabolic adaptation is complex and hence better understood by an integrated theoretical-experimental approach. Using a minimal kinetic model, we predicted a previously undescribed Low/Low (
Dongya Jia, B. Bishal Paudel, B. Bishal Paudel, B. Bishal Paudel, Corey E. Hayford, Corey E. Hayford, Corey E. Hayford, Keisha N. Hardeman, Keisha N. Hardeman, Herbert Levine, Herbert Levine, Herbert Levine, José N. Onuchic, José N. Onuchic, José N. Onuchic, José N. Onuchic, Vito Quaranta, Vito Quaranta   +17 more
doaj   +1 more source

The role of pfmdr1 in Plasmodium falciparum tolerance to artemether-lumefantrine in Africa [PDF]

, 2007
Objective Artemether-lumefantrine (AL), presently the most favoured combination therapy against uncomplicated Plasmodium falciparum malaria in Africa, has recently shown to select for the pfmdr1 86N allele.
Barnes, Basco, Chaiyaroj, Cowman, Dokomajilar, Duraisingh, Duraisingh, Hassan Alin, Hastings, Holmgren, Jambou, Johnson, Krishna, Martensson, Mugittu, Price, Price, Ritchie, Sisowath, Snounou, Uhlemann, Woodrow   +21 more
core   +2 more sources

Hyperosmotic stress induces PARP1‐mediated HPF1‐dependent mono(ADP‐ribosyl)ation

FEBS Letters, EarlyView.
Sorbitol‐induced hyperosmotic stress rapidly induces reversible mono(ADP‐ribosyl)ation (MARylation) on PARP1 without the signs of genotoxic signaling. We show that PARP1 autoMARylation is HPF1 dependent and forms hydroxylamine‐resistant O‐glycosidic linkages.
Anna Georgina Kopasz, Mihály Mérey, Rebeka Vásárhelyi, Ramóna Pék, Victor Imburchia, László Henn, Adrián Kószó, Nicholas D. Lakin, Ivan Ahel, Sébastien Huet, Ágnes Czibula, Gyula Timinszky   +11 more
wiley   +1 more source

Regular treatment with formoterol versus regular treatment with salmeterol for chronic asthma: serious adverse events [PDF]

, 2012
An increase in serious adverse events with both regular formoterol and regular salmeterol in chronic asthma has been demonstrated in previous Cochrane reviews.ObjectivesWe set out to compare the risks of mortality and non-fatal serious adverse events in ...
Altman, Blauw, Cates, Cates, Cates, Cates, Cates, Ducharme, Giembycz, Greenstone, Lipworth, Nelson, Ni Chroinin, Ni Chroinin, Pearce, Salpeter, Sears, Walters, Walters   +18 more
core   +1 more source

Potential therapeutic targeting of BKCa channels in glioblastoma treatment

Molecular Oncology, EarlyView.
This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak, Karolina Pytlak, Sandra Jaworowska, Bogusz Kulawiak, Piotr Bednarczyk   +4 more
wiley   +1 more source

LDAcoop: Integrating non‐linear population dynamics into the analysis of clonogenic growth in vitro

Molecular Oncology, EarlyView.
Limiting dilution assays (LDAs) quantify clonogenic growth by seeding serial dilutions of cells and scoring wells for colony formation. The fraction of negative wells is plotted against cells seeded and analyzed using the non‐linear modeling of LDAcoop.
Nikko Brix, Daniel Samaga, Katharina Gehr, Benedek Dankó, Mohamed Schumann, Guido Drexler, Ahmed Alnatsha, Georg Beyer, Ujjwal Mahajan, Martin Selmansberger, Julia Mayerle, Claus Belka, Horst Zitzelsberger, Kirsten Lauber   +13 more
wiley   +1 more source

Targeting tumor phenotypic plasticity and metabolic remodeling in adaptive cross-drug tolerance

Science Signaling, 2019
Resistance to unrelated chemotherapeutics in breast cancer cells is caused by a metabolic switch. Metabolic remodeling for drug resistance Commonly used chemotherapies can lead to resistance to drugs with different modes of actions.
Aaron Goldman, Aaron Goldman, Sachin K. Khiste, Sachin K. Khiste, Elizaveta Freinkman, A. Dhawan, B. Majumder, Jayanta Mondal, Jayanta Mondal, A. Pinkerton, Elliot Eton, R. Medhi, Vineethkrishna Chandrasekar, M. Rahman, T. Ichimura, K. Gopinath, P. Majumder, M. Kohandel, Shiladitya Sengupta   +18 more
semanticscholar   +1 more source

Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin

Molecular Oncology, EarlyView.
The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla, Jan Kosla, Magdalena Prechova, Lukas Frick, Patricia Bortel, Yasmin Borutzki, Andrea Bileck, Christopher Gerner, Samuel M. Meier‐Menches, Selma Osmanagic‐Myers, Martin Gregor   +10 more
wiley   +1 more source

Clinical considerations in transitioning patients with epilepsy from clonazepam to clobazam: a case series. [PDF]

, 2014
IntroductionIn treating refractory epilepsy, many clinicians are interested in methods used to transition patients receiving clonazepam to clobazam to maintain or increase seizure control, improve tolerability of patients' overall drug therapy regimens ...
Chung, Steve, Kuzniecky, Ruben, Perry, Michael Scott, Sankar, Raman, Sinha, Saurabh   +4 more
core   +1 more source

Nitrogen deprivation induces triacylglycerol accumulation, drug tolerance and hypervirulence in mycobacteria

Scientific Reports, 2019
Mycobacteria share with other actinomycetes the ability to produce large quantities of triacylglycerol (TAG), which accumulate as intracytoplasmic lipid inclusions (ILI) also known as lipid droplets (LD). Mycobacterium tuberculosis (M. tb), the etiologic
P. Santucci, M. Johansen, V. Point, Isabelle Poncin, Albertus Viljoen, J. Cavalier, L. Kremer, S. Canaan   +7 more
semanticscholar   +1 more source