Results 111 to 120 of about 411,089 (301)
Focused deterrence, selective targeting, drug trafficking and organised crime: Concepts and practicalities. Modernising drug law enforcement report 2. [PDF]
, 2013 The objective of this project, led by the International Drug Policy Consortium, with the participation of the International Security Research Department at Chatham House and the International Institute for Strategic Studies, is to collate and refine ...
Felbab Brown, Vanda
core
Identifying Mechanisms of Drug Tolerance in EGFR Mutant Lung Cancer [PDF]
, 2021 The majority of EGFR mutant lung adenocarcinomas respond well to EGFR tyrosine kinase inhibitors (TKIs). However, the majority of these responses are partial with drug tolerant residual disease remaining even at the time of maximal response.
Hu, Bomiao
core +1 more source
House of cellulose – a new hideout for drug tolerant Mycobacterium tuberculosis
Microbial Cell, 2016 Mycobacterium tuberculosis (Mtb) causes tuberculosis (TB). The treatment of TB requires administration of multiple drugs for long durations because of the unusual drug tolerance of Mtb. The phenotypic drug tolerance of genetically drug-susceptible Mtb in
Ashwani Kumar
doaj +1 more source
FEBS Open Bio, EarlyView.Chemotherapy side effects significantly impact cancer survivors' quality of life. Using protein levels in blood samples from breast cancer patients before and after 12 weeks of taxane treatment, we detected treatment‐dependent changes in calcium signaling and aging pathways associated with cancer recurrence.
Saira Munshani +6 more
wiley +1 more source
FEBS Open Bio, EarlyView.Pharmacological inhibition of PERK in a DEN‐induced mouse model of liver cancer does not reduce tumor burden but alters cellular stress signaling. Despite blocking PERK activity, downstream stress responses, including CHOP expression, remain active, suggesting compensatory mechanisms within the unfolded protein response that may influence tumor ...
Ada Lerma‐Clavero +5 more
wiley +1 more source
Zero tolerance drug program [PDF]
, 1999 Title from Web page (viewed Oct. 29, 2007).; "February 8, 1999."; Discusses legislation during the last legislative session requiring the Board of Parole, Dept.
Norman-Eady, Sandra.
core
A yeast model of 5‐oxoproline accumulation reveals a general toleration to 5‐oxoproline
FEBS Open Bio, EarlyView.Using a yeast model, we show that even high accumulation of 5‐oxoproline causes only mild cellular stress and does not trigger oxidative stress. Instead, cells adapt by activating efflux pumps and diverse protective pathways, suggesting that previously proposed harmful effects of 5‐oxoproline may arise from indirect metabolic imbalances rather than the
Pratiksha Dubey +4 more
wiley +1 more source
Antibiotic resistance and tolerance: What can drug delivery do against this global threat? [PDF]
Antimicrobial resistance and tolerance (AMR&T) are urgent global health concerns, with alarmingly increasing numbers of antimicrobial drugs failing and a corresponding rise in related deaths.
Aparicio Blanco, Juan +19 more
core +2 more sources
FEBS Open Bio, EarlyView.Drugs previously repurposed to target blood cancers reduced neuroblastoma and glioblastoma cell growth and viability. However, their levels of anticancer activity were different and their clinical application may be problematic due to side effects at effective doses.
Abhishek Kharawatkar +4 more
wiley +1 more source
Editorial: Drug-resistant Mycobacterium tuberculosis
Frontiers in Cellular and Infection Microbiology, 2023 Helena I. M. Boshoff +3 more
doaj +1 more source