Results 131 to 140 of about 5,956,077 (339)

Sensitivity and drug tolerance of antidrug antibody assays in relation to positive control characteristics.

Bioanalysis, 2018
AIM Detection and characterization of antidrug antibodies (ADA) play a key role in understanding the relation of ADA with safety and efficacy. Positive controls (PCs) are used to estimate the sensitivity and assay sensitivity in the presence of drug ...
D. Egging, Jos Verhagen, Karin de Laat-Arts, Benny de Wit, Tinie van Boekel, M. Buurman, Jochem Eigenhuijsen, Karin Lubbers-Geuijen, Roel Mulder   +8 more
semanticscholar   +1 more source

Molecular cancer prevention: Intercepting disease

Molecular Oncology, EarlyView.
Oncological practice must evolve, from treating established tumours to proactive cancer interception before clinical manifestation. This will require mechanistic insight into tumour initiation, validated biomarkers of early disease development and redesigned clinical trials, enabling cancer interception to become a core pillar of oncology with the ...
Charlotte Grieco, Tej Pandya, Charles Swanton   +2 more
wiley   +1 more source

Immune activation of the host cell induces drug tolerance in Mycobacterium tuberculosis both in vitro and in vivo

Journal of Experimental Medicine, 2016
Russell et al. show that activation of Mycobacterium tuberculosis–infected macrophages in vitro and in vivo enhances drug tolerance and renders the bacilli more refractory to drug-dependent killing.
Yancheng Liu, Shumin Tan, Lu Huang, R. Abramovitch, K. Rohde, M. Zimmerman, Chao Chen, V. Dartois, B. VanderVen, D. Russell   +9 more
semanticscholar   +1 more source

Metastasis on pause: How dormant tumor cells stay hidden within the tumor microenvironment and evade immune surveillance

Molecular Oncology, EarlyView.
Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary, Jose Javier Bravo‐Cordero   +1 more
wiley   +1 more source

The Dosing Strategy to Improve Adherence to Roflumilast in Treatment for Chronic Obstructive Lung Disease: A Systemic Review and Meta-Analysis

International Journal of COPD
Jonghoo Lee,1,* Jae-Uk Song2,* 1Department of Internal Medicine, Jeju National University Hospital, Jeju National University School of Medicine, Jeju, Republic of Korea; 2Division of Pulmonary and Critical Care Medicine, Department of Internal ...
Lee J, Song JU
doaj  

Early tolerance in pediatric liver allograft recipients [PDF]

, 1994
The authors report on six pediatric liver transplant recipients for whom allograft tolerance occurred shortly after transplantation (ie, less than 1.5 years). All the patients had associated life-threatening viral complications.
Adrianna Zeevi, Andreas G. Tzakis, Bakr Nour, Calne, Hector Ramos, Hoffman, Jorge Reyes, Keenan, Lee, Murase, Nancy Reinsmoen, Powrie, Reinsmoen, Reyes, Rolides, Romagnani, Satoru Todo, Starzl, Starzl, Starzl, Starzl, Starzl, Starzl, Takeuchi, Thomas E. Starzl, Tzakis   +25 more
core   +1 more source

Distinct histone modifications denote early stress-induced drug tolerance in cancer

OncoTarget, 2017
Besides somatic mutations or drug efflux, epigenetic reprogramming can lead to acquired drug resistance. We recently have identified early stress-induced multi-drug tolerant cancer cells termed induced drug-tolerant cells (IDTCs).
A. Emran, D. Marzese, D. Menon, M. Stark, J. Torrano, H. Hammerlindl, Gao Zhang, Patricia Brafford, M. Salomon, N. Nelson, S. Hammerlindl, D. Gupta, G. Mills, Yiling Lu, R. Sturm, K. Flaherty, D. Hoon, B. Gabrielli, M. Herlyn, H. Schaider   +19 more
semanticscholar   +1 more source

Erythropoietin modulates hepatic inflammation, glucose homeostasis, and soluble epoxide hydrolase and epoxides in high‐fat diet‐induced obese mice

FEBS Open Bio, EarlyView.
Erythropoietin administration suppresses hepatic soluble epoxide hydrolase (sEH) expression, leading to increased CYP‐derived epoxides. This is associated with a shift in hepatic macrophage polarization characterized by reduced M1 markers and increased M2 markers, along with reduced hepatic inflammation, suppressed hepatic lipogenesis, and attenuated ...
Takeshi Goda, Satoru Sugimoto, Chiharu Cho, Madoka Konishi, Nozomi Inoue, Satoshi Miyagaki, Yasuhiro Kawabe, Takuro Okamura, Masahide Hamaguchi, Hisakazu Nakajima, Michiaki Fukui, Masakazu Shinohara, Tomoko Iehara   +12 more
wiley   +1 more source

VLED and formula LED in the management of type 2 diabetes: defining the clinical need and research requirements [PDF]

, 2011
It has been known for many years that substantial weight loss, achieved by bariatric surgery or non-surgical means can mean normalise glucose tolerance.
Lean, M.
core   +1 more source

Enhanced Efflux Activity Facilitates Drug Tolerance in Dormant Bacterial Cells

Molecules and Cells, 2016
Summary Natural variations in gene expression provide a mechanism for multiple phenotypes to arise in an isogenic bacterial population. In particular, a sub-group termed persisters show high tolerance to antibiotics.
Yingying Pu, Zhilun Zhao, Yingxing Li, Jin Zou, Qi Ma, Yanna Zhao, Y. Ke, Yun Zhu, Huiyi Chen, M. Baker, Hao Ge, Yujie Sun, X. Xie, F. Bai   +13 more
semanticscholar   +1 more source