Results 61 to 70 of about 9,396,325 (306)

FKBP12 determines ligand-specific SMAD signaling in individual living endothelial cells

iScience
Summary: The BMP signaling pathway plays a pivotal role in regulating the formation and maintenance of our vascular system, employing a diverse set of ligands, receptors, and cytoplasmic mediators.
Zixin Huang, Sonja Lenhardt, Petra Snyder, Ahmed Bulldan, Felix Hausch, Alexander Loewer   +5 more
doaj   +1 more source

Emerging Regulatory Role of Nrf2 in Iron, Heme, and Hemoglobin Metabolism in Physiology and Disease

Frontiers in Veterinary Science, 2018
Iron has played an important role in energy production since the beginning of life, as iron-catalyzed redox reactions are required for energy production.
Shuya Kasai, Junsei Mimura, Taku Ozaki, Ken Itoh   +3 more
doaj   +1 more source

Microbiota and functional analyses of nitrogen-fixing bacteria in root-knot nematode parasitism of plants

Microbiome, 2023
Background Root-knot nematodes (RKN) are among the most important root-damaging plant-parasitic nematodes, causing severe crop losses worldwide. The plant rhizosphere and root endosphere contain rich and diverse bacterial communities.
Ye Li, Shaonan Lei, Zhiqiang Cheng, Lingyue Jin, Ting Zhang, Lian-Ming Liang, Linjie Cheng, Qinyi Zhang, Xiaohong Xu, Canhua Lan, Chaojun Lu, Minghe Mo, Ke-Qin Zhang, Jianping Xu, Baoyu Tian   +14 more
doaj   +1 more source

The Aging Stress Response [PDF]

Molecular Cell, 2010
Aging is the outcome of a balance between damage and repair. The rate of aging and the appearance of age-related pathology are modulated by stress response and repair pathways that gradually decline, including the proteostasis and DNA damage repair networks and mitochondrial respiratory metabolism.
Haigis, Marcia C., Yankner, Bruce A.
openaire   +2 more sources

Chemotherapy for Spinal Cord Intramedullary Pediatric Low‐Grade Glioma—A Systematic Literature Review

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Pediatric intramedullary low‐grade gliomas (PIMLGGs) are rare neoplasms that present unique clinical and management challenges. Although surgery remains the primary tool for tissue diagnosis and decompression, complete gross‐total resection is frequently unfeasible due to the infiltrative nature of these lesions.
Olga M. Sergeenko, Segev Gabay, Jonathan Roth, Amit Ringel, Rina Dvir, Shlomi Constantini   +5 more
wiley   +1 more source

Comparative Evaluation of Hemodiafiltration, Hemoperfusion, and Standard Hemodialysis on Efficacy, Inflammatory Control, Dialysis Adequacy, and Safety in End‐Stage Renal Disease: A Prospective Observational Study

Therapeutic Apheresis and Dialysis, EarlyView.
ABSTRACT Background Chronic micro‐inflammation in patients with end‐stage renal disease (ESRD) is a significant driver of cardiovascular complications and diminished quality of life. While standard hemodialysis (SHD) effectively manages small‐molecule clearance, its ability to remove medium‐to‐large uremic toxins—the primary catalysts of systemic ...
Hongwei Zuo, Weisi Dai, Jie Mao, Mei Ye, Xingshan Lu, Xiaocui Zhang   +5 more
wiley   +1 more source

Genome-wide screen reveals glycerol-induced aminoglycoside potentiation against Staphylococcus aureus via boosting GlpK-initiated energy metabolism

Antimicrobial Agents and Chemotherapy
Potentiation of existing antibiotics represents a promising strategy for combating the global health crisis of antibiotic resistance. Here we report that 1 min co-treatment with glycerol markedly enhances aminoglycoside efficacy against stationary-phase ...
Yaqin Xing, Mengmeng Bian, Xuebing Huang, Boyan Lv, Zhijie Huang, Xianzhang Jiang, Weiya Huang, Huping Xue, Hangyu Zhao, Jianfeng Huang, Xinmiao Fu   +10 more
doaj   +1 more source

Modulation of Cadmium Tolerance in Rice: Insight into Vanillic Acid-Induced Upregulation of Antioxidant Defense and Glyoxalase Systems

Plants, 2020
Cadmium (Cd) is a toxic heavy metal that enters the human food chain from the soil via plants. Increased Cd uptake and translocation in plants alters metabolism andreduces crop production.
M.H.M. Borhannuddin Bhuyan, Khursheda Parvin, Sayed Mohammad Mohsin, Jubayer Al Mahmud, Mirza Hasanuzzaman, Masayuki Fujita   +5 more
doaj   +1 more source

The emerging role and therapeutic implications of bacterial and parasitic deubiquitinating enzymes

Frontiers in Immunology, 2023
Deubiquitinating enzymes (DUBs) are emerging as key factors for the infection of human cells by pathogens such as bacteria and parasites. In this review, we discuss the most recent studies on the role of deubiquitinase activity in exploiting and ...
Markus Wehrmann, Markus Wehrmann, David Vilchez, David Vilchez, David Vilchez, David Vilchez   +5 more
doaj   +1 more source

Safety of Daprodustat for the Treatment of Chronic Kidney Disease Anemia: Final Analysis of a Multicenter Postmarketing Surveillance Study in Japan

Therapeutic Apheresis and Dialysis, EarlyView.
ABSTRACT Introduction This final analysis of a multicenter, prospective postmarketing surveillance study evaluated the safety of daprodustat in patients with chronic kidney disease anemia in routine clinical practice in Japan. Methods Patients who initiated daprodustat between September 2020 and July 2022 were registered.
Tadao Akizawa, Kyomi Kanaya, Kiyomi Aizawa, Masanori Onoki, Hirofumi Ozeki, Kazuko Suzuki, Ai Hayashi, Tomohiko Asamura   +7 more
wiley   +1 more source