Results 71 to 80 of about 9,396,325 (306)

Suppression of the physiological stress response is not stress

Trends in Ecology & Evolution, 2023
We must differentiate between stressful and harsh environments to understand animals’ resilience to global change. Harshness is not stress. Stressful environments activate the physiological stress response to increase energy availability, while harsh environments inhibit the physiological stress response to save energy.
Makuya, Lindelani, Pillay, Neville, Rimbach, Rebecca, Schradin, Carsten   +3 more
openaire   +4 more sources

Forecasting the Dialysis Burden in Japan: Validation‐Based Projections of Prevalence and Incidence Through 2050

Therapeutic Apheresis and Dialysis, EarlyView.
ABSTRACT Background Japan has one of the highest dialysis prevalence rates worldwide and a shrinking, aging population. Whether dialysis burden has entered a sustained post‐peak phase or whether recent declines partly reflect pandemic‐related disruptions remains uncertain.
Hatice Şahin, Berrak Itır Aylı, Nüket Paksoy   +2 more
wiley   +1 more source

Distinguishing the Effects of Stress Intensity and Stress Duration in Plant Responses to Salinity

, 2023
Species-specific variation in response to stress is a key driver of ecological patterns. As climate change alters stress regimes, coastal plants are experiencing intensifying salinity stress due to sea-level rise and more intense storms.
Keryn Gedan, Caitlin DiCara
core   +1 more source

Genome‐wide screen reveals a universal role of ATP in ciprofloxacin tolerance among genetically distinct Escherichia coli persisters

mLife
Bacterial persisters show tolerance to bactericidal antibiotics and play essential roles in chronic infections; however, the general mechanisms underlying persister formation and antibiotic tolerance remain insufficiently characterized.
Zhenfang Mei, Yawen Cai, Jianfeng Huang, Kedong Zhao, Zuqin Zhang, Dandan Yu, Shiyan Lu, Zeying Lai, Thomas K. Wood, Xinmiao Fu   +9 more
doaj   +1 more source

Regulation of Nrf2 by Mitochondrial Reactive Oxygen Species in Physiology and Pathology

Biomolecules, 2020
Reactive oxygen species (ROS) are byproducts of aerobic respiration and signaling molecules that control various cellular functions. Nrf2 governs the gene expression of endogenous antioxidant synthesis and ROS-eliminating enzymes in response to various ...
Shuya Kasai, Sunao Shimizu, Yota Tatara, Junsei Mimura, Ken Itoh   +4 more
doaj   +1 more source

Organoids in pediatric cancer research

FEBS Letters, EarlyView.
Organoid technology has revolutionized cancer research, yet its application in pediatric oncology remains limited. Recent advances have enabled the development of pediatric tumor organoids, offering new insights into disease biology, treatment response, and interactions with the tumor microenvironment.
Carla Ríos Arceo, Jarno Drost
wiley   +1 more source

Eukaryotic response to hypothermia in relation to integrated stress responses

, 2020
Eukaryotic cells respond to hypothermic stress through a series of regulatory mechanisms that preserve energy resources and prolong cell survival. These mechanisms include alterations in gene expression, attenuated global protein synthesis and changes in
Adjirackor, N. A., Harvey, S. C., Harvey, K. E.   +2 more
core   +1 more source

Regulation of the Expression of DAPK1 by SUMO Pathway

Biomolecules, 2019
Death Associated Protein Kinase 1 (DAPK1) is an important signaling kinase mediating the biological effect of multiple natural biomolecules such as IFN-γ, TNF-α, curcumin, etc.
Qingshui Wang, Xiuli Zhang, Ling Chen, Shuyun Weng, Yun Xia, Yan Ye, Ke Li, Ziqiang Liao, Pengchen Chen, Khaldoon Alsamman, Chen Meng, Craig Stevens, Ted R. Hupp, Yao Lin   +13 more
doaj   +1 more source

The human gut microbiome across the life course

FEBS Letters, EarlyView.
Despite significant individual variation and continuous change throughout life, the human gut microbiome follows some life stage‐specific trends. This article provides a brief overview of how gut microbiome composition shifts across different phases of life. Created in BioRender. Özkurt, E. (2026) https://BioRender.com/8q4nrnc.
Alise J. Ponsero, Basak Bahcivanci, Antonietta Hayhoe, Animesh Acharjee, Ezgi Özkurt   +4 more
wiley   +1 more source

Phase separation as an emerging regulatory framework in antibody class switching and genome stability

Frontiers in Immunology
The spatial and temporal organization of nuclear processes is increasingly interpreted through principles associated with liquid–liquid phase separation (LLPS), whereby multivalent interactions among proteins and nucleic acids generate dynamic ...
Ahmed M. Refaat, Ahmed M. Refaat, Hidetaka Shimizu, Takaaki Yasuhara   +3 more
doaj   +1 more source