Mechanisms and therapeutic opportunities of the ribotoxic stress response in cancer. [PDF]
Cancer cells' high translational demand creates opportunities to therapeutically target ribosome function. Ribosome stalling and collisions activate ZAKα and the ribotoxic stress response (RSR), which can trigger rapid, p53‐independent apoptosis in cancer.
Kim A +7 more
europepmc +2 more sources
Lipopolysaccharide, high glucose and saturated fatty acids induce endoplasmic reticulum stress in cultured primary human adipocytes : salicylate alleviates this stress [PDF]
Recent findings indicate that endoplasmic reticulum (ER) stress is significantly increased in adipose tissue of obese human subjects and is critical to the initiation and integration of pathways of inflammation and insulin action.
Saif Alhusaini +18 more
core +1 more source
Cold stress is a prominent abiotic factor that adversely affects the growth and yield of pears, consequently restricting the cultivation range and resulting in substantial economic losses for the pear industry.
Yuxin Zhang +7 more
core +1 more source
Screening for functional IRESes using α-complementation system of β-galactosidase in Pichia pastoris
Background Pichia pastoris is becoming a promising chassis cell for metabolic engineering and synthetic biology after its whole genome and transcriptome sequenced. However, the current systems for multigene co-expression in P. pastoris are not efficient.
Yide Huang +5 more
doaj +1 more source
Natural Compounds That Enhance Motor Function in a Mouse Model of Muscle Fatigue
Musculoskeletal disease can be a serious condition associated with aging that may lead to fractures and a bedridden state due to decreased motor function.
Shuichi Shibuya +4 more
doaj +1 more source
E' un Editorial richiesto sull'argomento, motivo per il quale non c'e ...
Diego Breviario, Annamaria Genga
openaire +1 more source
Architecture, Dynamics, and Function of the General Stress Response System in B. subtilis [PDF]
Cells exhibit diverse and dynamic responses to stress. However, in many cases it remains unclear what the dynamics are, how they are generated, and why they are beneficial to the cell or organism. To investigate these issues we studied the General Stress
Young, Jonathan Wan
core +1 more source
Antibiotic‐tolerant persisters are often implicated in treatment failure of chronic and relapsing bacterial infections, but the underlying molecular mechanisms have remained elusive.
Cinzia Fino +5 more
doaj +1 more source
Revealing the Variation and Stability of Bacterial Communities in Tomato Rhizosphere Microbiota
Microorganisms that colonize the plant rhizosphere can contribute to plant health, growth and productivity. Although the importance of the rhizosphere microbiome is known, we know little about the underlying mechanisms that drive microbiome assembly and ...
Zhiqiang Cheng +10 more
doaj +1 more source
Higher use of techniques studied and performance in melee combat produce a higher psychophysiological stress response [PDF]
We aimed to analyse the effectiveness of an operative training in soldiers' psychophysiological and melee combat performance. Nineteen soldiers performed a 50-hr training for 10 weeks. After training, they were divided into two groups: higher performance
Diaz Manzano, Montaña +11 more
core +1 more source

