Results 21 to 30 of about 80,032 (218)

Critical Care Demand and Intensive Care Supply for Patients in Japan with COVID-19 at the Time of the State of Emergency Declaration in April 2020: A Descriptive Analysis

Medicina, 2020
Background and objectives: The coronavirus disease 2019 (COVID-19) pandemic is overwhelming Japan’s intensive care capacity. This study aimed to determine the number of patients with COVID-19 who required intensive care and to compare the numbers with ...
Yosuke Fujii, Kiichi Hirota
doaj   +1 more source

Ceramide in Stress Response [PDF]

, 2010
Evidence has consistently indicated that activation of sphingomyelinases and/or ceramide synthases and the resulting accumulation of ceramide mediate cellular responses to stressors such as lipopolysaccharide, interleukin 1beta, tumor necrosis factor alpha, serum deprivation, irradiation and various antitumor treatments.
Nikolova-Karakashian, Mariana N., Rozenova, Krassimira A.   +1 more
openaire   +2 more sources

Analysis of the community composition and bacterial diversity of the rhizosphere microbiome across different plant taxa

MicrobiologyOpen, 2019
Rhizobacteria play an important role in bridging the soil and plant microbiomes and improving the health and growth of plants. In this study, the bacterial community structures and compositions of rhizosphere microbiomes associated with six plant species,
Shaonan Lei, Xiaohong Xu, Zhiqiang Cheng, Juan Xiong, Rongqin Ma, Lanlan Zhang, Xiaorong Yang, Yunxi Zhu, Binghuo Zhang, Baoyu Tian   +9 more
doaj   +1 more source

The α-mating factor secretion signals and endogenous signal peptides for recombinant protein secretion in Komagataella phaffii

Biotechnology for Biofuels and Bioproducts, 2022
Background The budding yeast Komagataella phaffii (Pichia pastoris) is widely employed to secrete proteins of academic and industrial interest.
Chenwei Zou, Lingfang Lu, Shengyan Wang, Chenshan Zhang, Xuequn Chen, Yao Lin, Yide Huang   +6 more
doaj   +1 more source

Serine-Threonine Kinases Encoded by Split hipA Homologs Inhibit Tryptophanyl-tRNA Synthetase

mBio, 2019
Type II toxin-antitoxin (TA) modules encode a stable toxin that inhibits cell growth and an unstable protein antitoxin that neutralizes the toxin by direct protein-protein contact.
Stine Vang Nielsen, Kathryn Jane Turnbull, Mohammad Roghanian, Rene Bærentsen, Maja Semanjski, Ditlev E. Brodersen, Boris Macek, Kenn Gerdes   +7 more
doaj   +1 more source

5-Methylindole Potentiates Aminoglycoside Against Gram-Positive Bacteria Including Staphylococcus aureus Persisters Under Hypoionic Conditions

Frontiers in Cellular and Infection Microbiology, 2020
Antibiotic resistance/tolerance has become a severe threat to human and animal health. To combat antibiotic-resistant/tolerant bacteria, it is of significance to improve the efficacy of traditional antibiotics.
Fengqi Sun, Mengmeng Bian, Zhongyan Li, Boyan Lv, Yuanyuan Gao, Yuanyuan Gao, Yan Wang, Xinmiao Fu, Xinmiao Fu   +8 more
doaj   +1 more source

A pilot cross-sectional investigation of chronic shame as a mediator of the relationship between subjective social status and self-rated health among middle-aged adults

Health Psychology and Behavioral Medicine, 2023
Subjective social status (SSS) is an important independent predictor of health outcomes, however, the pathways through which it affects health are poorly understood.
Ellen C. McGarity-Shipley, Eun-Young Lee, Kyra E. Pyke   +2 more
doaj   +1 more source

HipA-Mediated Phosphorylation of SeqA Does not Affect Replication Initiation in Escherichia coli

Frontiers in Microbiology, 2018
The SeqA protein of Escherichia coli is required to prevent immediate re-initiation of chromosome replication from oriC. The SeqA protein is phosphorylated at the serine-36 (Ser36) residue by the HipA kinase.
Leise Riber, Birgit M. Koch, Line Riis Kruse, Elsa Germain, Anders Løbner-Olesen   +4 more
doaj   +1 more source

A novel RofA-family transcriptional regulator, GadR, controls the development of acid resistance in Listeria monocytogenes

mBio, 2023
Stomach acid provides a significant innate barrier to the entry of the food-borne pathogen Listeria monocytogenes into the human gastrointestinal tract.
Jialun Wu, Olivia McAuliffe, Conor P. O'Byrne   +2 more
doaj   +1 more source

A low acriflavine dose strongly potentiates the antimicrobial effect of blue light on Staphylococcus aureus

Journal of Photochemistry and Photobiology
Staphylococcus aureus infections are difficult to treat in chronic wounds due to biofilm formation and are frequently compounded by antibiotic resistance, necessitating the development of alternative therapeutic approaches.
Rachel Allen, Yinka Somorin, Matthew Slemon, Eva Zekaite, Conall Haugh, Chloe Hobbs, Merve S. Zeden, James P. O’Gara, Conor O’Byrne   +8 more
doaj   +1 more source