Results 1 to 10 of about 111,661 (295)
Cell-cell fusion limits activation of the unfolded protein response induced by the Nipah virus glycoproteins [PDF]
Journal of VirologyThe productive replication of highly pathogenic Nipah virus (NiV) relies on the host cell for the synthesis and correct folding of the viral glycoproteins, which can cause ER stress and activation of the unfolded protein response (UPR). While the UPR can
Paula Jordan +5 more
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A high-throughput drug discovery pipeline to optimize kidney normothermic machine perfusion
Frontiers in Physiology, 2022 Kidney transplantation is the only definitive therapy for end-stage kidney disease. The shortage of organs for transplantation is the main limitation of this life-saving treatment.
Smilla Hofmann +8 more
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Crosstalk Between ER Stress, Unfolded Protein Response (UPR) and Wnt Signaling Pathway in Cancer [PDF]
Iranian Journal of Colorectal Research, 2020 : 1. Context Endoplasmic reticulum stress (ER stess) is associated with endoplasmic reticulum perturbation homeostasis. Prolonged ER stress conditions may induce cell death. Unfolded protein response (UPR) attempts to restore normal cell conditions.
Morvarid Siri +3 more
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Mechanism of Hsp70 specialized interactions in protein translocation and the unfolded protein response [PDF]
Open Biology, 2020 Hsp70 chaperones interact with substrate proteins in a coordinated fashion that is regulated by nucleotides and enhanced by assisting cochaperones.
Natacha Larburu +4 more
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RNA Biology, 2022 Cells of metazoans respond to internal and external stressors by activating stress response pathways that aim for re-establishing cellular homoeostasis or, if this cannot be achieved, triggering programmed cell death. Problems during translation, arising
Soumasree De, Oliver Mühlemann
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Crosstalk between RNA Metabolism and Cellular Stress Responses during Zika Virus Replication
Pathogens, 2020 Zika virus (ZIKV) is a mosquito-borne virus associated with neurological disorders such as Guillain-Barré syndrome and microcephaly. In humans, ZIKV is able to replicate in cell types from different tissues including placental cells, neurons, and ...
Aarón Oyarzún-Arrau +4 more
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Frontiers in Microbiology, 2014 Varicella-zoster virus (VZV) is a human herpesvirus that spreads to children as varicella or chicken pox. The virus then establishes latency in the nervous system and re-emerges, typically decades later, as zoster or shingles. We have reported previously
John Earl Carpenter, Charles eGrose
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Endoplasmic Reticulum Involvement in Yeast Cell Death
Frontiers in Oncology, 2012 Yeast cells undergo programmed cell death (PCD) with characteristic markers associated with apoptosis in mammalian cells including chromatin breakage, nuclear fragmentation, reactive oxygen species generation, and metacaspase activation.
Nicanor eAustriaco
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GRP78 and endoplasmic reticulum stress in endometrial cancer
Frontiers in Medicine, 2014 Endometrial cancer is a common gynecologic malignancy often diagnosed at early stage. In spite of a huge advance in our understanding of endometrial cancer biology, therapeutic modalities do not have significantly changed over the past 40 years.
Luca eUlianich, Luigi eInsabato
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ER stress and hepatic lipid metabolism
Frontiers in Genetics, 2014 The endoplasmic reticulum (ER) is an important player in regulating protein synthesis and lipid metabolism. Perturbation of ER homeostasis, referred as ER stress, has been linked to numerous pathological conditions, such as inflammation, cardiovascular ...
Huiping eZhou +2 more
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