Results 11 to 20 of about 111,661 (295)
Theme Series – UPR in cancer [PDF]
Seminars in Cancer Biology, 2015 Over the past decade endoplasmic reticulum (ER) stress signaling pathways have collectively emerged as an essential mechanism at the crossroads of the cellular functions involved in key steps of cancer development. ER stress signaling has pleiotropic roles in cancer, and is involved at the level of cell transformation, tumor growth and metastasis as ...
Hetz, Claudio, Chevet, Eric
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The UPR in atherosclerosis [PDF]
Seminars in Immunopathology, 2013 Multiple systemic factors and local stressors in the arterial wall can disturb the functions of endoplasmic reticulum (ER), causing ER stress in endothelial cells (ECs), smooth muscle cells (SMCs), and macrophages during the initiation and progression of atherosclerosis. As a protective response to restore ER homeostasis, the unfolded protein response (
Alex X, Zhou, Ira, Tabas
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Biology of the Cell, 2023 AbstractProtein folding and protein maturation largely occur in the controlled environment of the Endoplasmic Reticulum (ER). Perturbation to the correct functioning of this organelle leads to altered proteostasis and accumulation of misfolded proteins in the ER lumen.
Ilaria Pontisso +3 more
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médecine/sciences, 2007 The endoplasmic reticulum (ER) is the first compartment in the secretory pathway. In the ER, proteins fold into their native configuration and are modified by post-translational modifications. Perturbations that alter ER homeostasis therefore disrupt folding and lead to the accumulation of unfolded proteins. These perturbations include modifications of
Fabienne Foufelle, Pascal Ferré
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Metabolism and the UPR mt [PDF]
Molecular Cell, 2016 During mitochondrial dysfunction or the accumulation of unfolded proteins within mitochondria, cells employ a transcriptional response known as the mitochondrial unfolded protein response (UPR(mt)) to promote cell survival along with the repair and recovery of defective mitochondria.
Lin, Yi-Fan, Haynes, Cole M.
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“Translating” Tumor Hypoxia: Unfolded Protein Response (UPR)–Dependent and UPR-Independent Pathways [PDF]
Molecular Cancer Research, 2006 Abstract Poor oxygenation (hypoxia) is present in the majority of human tumors and is associated with poor prognosis due to the protection it affords to radiotherapy and chemotherapy. Hypoxia also elicits multiple cellular response pathways that alter gene expression and affect tumor progression, including two recently identified ...
Constantinos, Koumenis +1 more
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A Systems Biology Approach towards Deciphering the Unfolded Protein Response in Huntington's Disease [PDF]
, 2012 Although the disease causing gene huntingtin has been known for some time, the exact cause of neuronal cell death during _Huntington's disease_ (HD) remains unknown.
Kameshwar R. Ayasolla +2 more
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Next-generation proteasome inhibitor oprozomib synergizes with modulators of the unfolded protein response to suppress hepatocellular carcinoma [PDF]
, 2016 Hepatocellular carcinoma (HCC) responds poorly to conventional systemic therapies. The first-in-class proteasome inhibitor bortezomib has been approved in clinical use for hematologic malignancies and has shown modest activity in solid tumors, including ...
Bogaerts, Eliene +12 more
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The Unfolded Protein Response and its potential role in Huntington's disease [PDF]
, 2012 Huntington's disease (HD) is a progressive, neurodegenerative disease with fatal outcome. Although the disease-causing gene (huntingtin) has been known for some time, the exact cause of neuronal cell death is still unknown.
Kamesh Ayasolla +2 more
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Placental growth factor inhibition modulates the interplay between hypoxia and unfolded protein response in hepatocellular carcinoma [PDF]
, 2016 Background: Hepatocellular carcinoma (HCC) is a leading cause of cancer-related mortality. We previously showed that the inhibition of placental growth factor (PlGF) exerts antitumour effects and induces vessel normalisation, possibly reducing hypoxia ...
Bogaerts, Eliene +13 more
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