UPR Project at BCU South Sudan Stakeholder Report [PDF]
, 2021 Birmingham City University's Centre for Human Rights was created in 2014 to promote human rights, ensure access to justice, and enhance the rule of law around the world.We seek to achieve thisthrough leading research, education, and ...
Yorke, Jon, Nazir, Amna, Storey, Alice
core +3 more sources
TP53 R249S mutation in hepatic organoids captures the predisposing cancer risk
Hepatology, EarlyView., 2022 The systematic approach in elucidating the gain‐of‐function (GOF) roles of TP53 mutations in early liver carcinogenesis. Unique downstream targets of TP53 L3 mutations were identified from chormatin immunoprecipitation sequencing in HCC cell lines, followed by a series of validation assays to substantiate the exclusive transcriptional regulations ...
Yin Kau Lam +10 more
wiley +1 more source
QRICH1 Disrupts Endoplasmic Reticulum Homeostasis and Amplifies NF-κB Signaling in Periodontal Ligament Stem Cells to Exacerbate Diabetic Periodontitis. [PDF]
Adv Sci (Weinh)QRICH1 has been established as a key factor contributing to impaired osteogenic potential and accelerated apoptosis of PDLSCs in diabetic periodontitis. QRICH1 not only significantly enhances UPR‐associated apoptotic signaling but also amplifies NF‐κB‐mediated inflammatory responses. Its inhibition restores osteogenic capacity and reduces alveolar bone
Li H +9 more
europepmc +2 more sources
The Unfolded Protein Response and its potential role in Huntington's disease [PDF]
, 2012 Huntington's disease (HD) is a progressive, neurodegenerative disease with fatal outcome. Although the disease-causing gene (huntingtin) has been known for some time, the exact cause of neuronal cell death is still unknown.
Ravi K. R. Kalathur +2 more
core +1 more source
Endoplasmic reticulum stress-induced PCD and caspase-like activities involved.
Frontiers in Plant Science, 2014 Plant cells, like cells from other kingdoms, have the ability to self-destruct in a genetically controlled manner. This process is defined as Programmed Cell Death (PCD).
Yao-min eCAI, Jia eYU, Patrick eGALLOIS
doaj +1 more source
Training for Legal Professionals in The Gambia on the Universal Periodic Review
The workshop is organized with the support of Dr Michael Lane (University of Worcester, UK) and Dr Frederick Cowell (Birkbeck, University of London, UK).
Cowell, F., Lane, Michael
core +4 more sources
Proteostasis in the regulation of pancreatic islet cell plasticity. [PDF]
J Diabetes InvestigAdaptive proteostasis integrates protein synthesis, folding, trafficking, and degradation through ISR, UPR, ER stress responses, autophagy, and proteasomal degradation. In pancreatic islet cells, this coordinated network preserves protein quality, secretory function, proliferation, and survival, enabling adaptation to metabolic stress and aging while ...
Shirakawa J.
europepmc +2 more sources
Molecular mechanisms involved in endoplasmic reticulum stress development: What do we know today [PDF]
Medicinski PodmladakEndoplasmic reticulum (ER) is an intracellular organelle involved in protein synthesis and folding. When the balance between cell needs for proteins and ER capacity to fold proteins is disrupted, nonfunctional, unfolded, or misfolded proteins accumulate ...
Vidičević-Novaković Sašenka +1 more
doaj +1 more source
Endoplasmic reticulum and Golgi stress in microcephaly
Cell Stress, 2019 Microcephaly is a neurodevelopmental condition characterized by a small brain size associated with intellectual deficiency in most cases and is one of the most frequent clinical sign encountered in neurodevelopmental disorders.
Sandrine Passemard +3 more
doaj +1 more source