Results 31 to 40 of about 111,661 (295)

ZIKV infection activates the IRE1-XBP1 and ATF6 pathways of unfolded protein response in neural cells. [PDF]

, 2018
BACKGROUND: Many viruses depend on the extensive membranous network of the endoplasmic reticulum (ER) for their translation, replication, and packaging. Certain membrane modifications of the ER can be a trigger for ER stress, as well as the accumulation ...
Fu, Z, Hu, Q, Ke, X, Li, P, Liu, Y, Sun, J, Tan, Z, Wang, H, Zhang, W, Zhang, Y, Zheng, C, Zheng, Z   +11 more
core   +1 more source

Endoplasmic reticulum and Golgi stress in microcephaly

Cell Stress, 2019
Microcephaly is a neurodevelopmental condition characterized by a small brain size associated with intellectual deficiency in most cases and is one of the most frequent clinical sign encountered in neurodevelopmental disorders.
Sandrine Passemard, Franck Perez, Pierre Gressens, Vincent El Ghouzzi   +3 more
doaj   +1 more source

TP53 R249S mutation in hepatic organoids captures the predisposing cancer risk

Hepatology, EarlyView., 2022
The systematic approach in elucidating the gain‐of‐function (GOF) roles of TP53 mutations in early liver carcinogenesis. Unique downstream targets of TP53 L3 mutations were identified from chormatin immunoprecipitation sequencing in HCC cell lines, followed by a series of validation assays to substantiate the exclusive transcriptional regulations ...
Yin Kau Lam, Jianqing Yu, Hao Huang, Xiaofan Ding, Alissa M. Wong, Howard H. Leung, Anthony W. Chan, Kelvin K. Ng, Mingjing Xu, Xin Wang, Nathalie Wong   +10 more
wiley   +1 more source

Endoplasmic reticulum stress-induced cellular dysfunction and cell death in insulin-producing cells results in diabetes-like phenotypes in Drosophila

Biology Open, 2019
The destruction of pancreatic β cells leads to reduced insulin secretion and eventually causes diabetes. Various types of cellular stress are thought to be involved in destruction and/or malfunction of these cells. We show that endoplasmic reticulum (ER)
Hiroka Katsube, Yukiko Hinami, Tatsuki Yamazoe, Yoshihiro H. Inoue   +3 more
doaj   +1 more source

Kinetics of thermal degradation of unsaturated polyester resin and their composite with porcelain powder: determination of activation energy

Journal of Applied Surfaces and Interfaces, 2020
The thermal degradation of an unsaturated polyester resin and the composite fabricated with porcelain powder obtained from ceramic waste and the resin was studied under non isothermal conditions in argon atmosphere. For kinetic analysis, the TGA/DTG data
Mohamed Farsane, Abdellah Anouar, Souad Chah, Miloud Bouzziri   +3 more
doaj   +1 more source

NF-κB signaling and crosstalk during carcinogenesis

4 open, 2019
Transcription factors (TFs) are proteins that control the transcription of genetic information from DNA to mRNA by binding to specific DNA sequences either on their own or with other proteins as a complex.
Brücher Björn L.D.M., Lang Florian, Jamall Ijaz S.   +2 more
doaj   +1 more source

Dual EGFR inhibition in combination with anti-VEGF treatment: a phase I clinical trial in non-small cell lung cancer. [PDF]

, 2013
BackgroundPreclinical data indicate EGFR signals through both kinase-dependent and independent pathways and that combining a small-molecule EGFR inhibitor, EGFR antibody, and/or anti-angiogenic agent is synergistic in animal models.MethodsWe conducted a ...
Bastida, Christel, Falchook, Gerald S, Fu, Siqing, Hong, David S, Jiang, Yunfang, Kurzrock, Razelle, Morgan-Linnell, Sonia K, Naing, Aung, Piha-Paul, Sarina A, Tsimberidou, Apostolia M, Wheler, Jennifer J, Zinner, Ralph   +11 more
core   +2 more sources

Cell‐nonautonomous control of the UPR [PDF]

EMBO reports, 2012
A study published in this issue of EMBO reports shows that the UPR at the intestine is under the control of the nervous system, to facilitate response to stress. This new way of understanding how the UPR is controlled at an organismal level is discussed here.
Martínez, Gabriela, Hetz Flores, Claudio   +1 more
openaire   +3 more sources

Cancer microenvironment and endoplasmic reticulum stress response [PDF]

, 2015
Different stressful conditions such as hypoxia, nutrient deprivation, pH changes, or reduced vascularization, potentially able to act as growth-limiting factors for tumor cells, activate the unfolded protein response (UPR).
Conti, S, Facchiano, A, Filippini, Antonio, Giampietri, Claudia, Petrungaro, Simonetta, Ziparo, Elio   +5 more
core   +4 more sources

Effectors Targeting the Unfolded Protein Response during Intracellular Bacterial Infection

Microorganisms, 2021
The unfolded protein response (UPR) is a homeostatic response to endoplasmic reticulum (ER) stress within eukaryotic cells. The UPR initiates transcriptional and post-transcriptional programs to resolve ER stress; or, if ER stress is severe or prolonged,
Manal H. Alshareef, Elizabeth L. Hartland, Kathleen McCaffrey   +2 more
doaj   +1 more source