Results 51 to 60 of about 101,011 (227)
Analysis of the management process of doctoral training in three Cuban universities
Revista MENDIVE, 2023 Doctoral training is the integrating nucleus not only of substantive university processes (teaching, research and extension) but also of the different forms of postgraduate and guarantor of university quality and, especially, of higher education ...
Tania Vargas Fernández +3 more
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Disease Models & Mechanisms, 2014 The unfolded protein response (UPR) is a complex network of sensors and target genes that ensure efficient folding of secretory proteins in the endoplasmic reticulum (ER). UPR activation is mediated by three main sensors, which regulate the expression of
Ana M. Vacaru +8 more
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Inhomogeneous spatial distribution of the magnetic transition in an iron-rhodium thin film
Nature Communications, 2017 Films of iron-rhodium alloy undergo a magnetic transition at 100°C, and so are attractive for applications, but a detailed understanding of the transition mechanism has not been achieved.
C. Gatel +7 more
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Animal Research and One Health, EarlyView.Cows with ketosis during the perinatal period often experience damage to the liver, a core metabolic organ, thereby exacerbating the disease's inherent vicious cycle. This study indicates that serum 3‐IAA concentrations were reduced in ketotic cows and show a significant negative correlation with hepatic TG content.
Dandan Qi +15 more
wiley +1 more source
Frontiers in Cell and Developmental BiologyThe endoplasmic reticulum (ER) plays a central role in protein and lipid biosynthesis, quality control, and secretion. While its functional roles are well characterized, the mechanisms underlying ER biogenesis remain less defined.
Payam Benyamini, David I. Meyer
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Human Monocytic Models Reveal Genotype‐Dependent Inflammatory Programs in VEXAS Syndrome
Arthritis &Rheumatology, EarlyView.Objective VEXAS syndrome is a severe X‐linked autoinflammatory disorder caused by somatic mutations in ubiquitin‐like modifier activating enzyme 1 (UBA1), with clinical outcomes that vary by UBA1 genotype. We aimed to elucidate genotype‐specific inflammatory programs and identify potential therapeutic targets.
Kana Higashitani +10 more
wiley +1 more source
Understanding the impact of ER stress on lung physiology
Frontiers in Cell and Developmental BiologyHuman lungs consist of a distinctive array of cell types, which are subjected to persistent challenges from chemical, mechanical, biological, immunological, and xenobiotic stress throughout life.
Zhiling Fu, Wei Wang, Yuan Gao
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Biological Reviews, EarlyView.ABSTRACT Heat stress (HS) is an increasing threat to male reproductive health, disrupting spermatogenesis through complex and interdependent cellular responses within the seminiferous epithelium. Although excessive reactive oxygen species (ROS) production is a hallmark of HS, ROS also act as central regulators of cell fate decisions beyond their role ...
Ribrio Ivan Tavares Pereira Batista
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Vascular BiologyActivating transcription factor 6 (ATF6) is an unfolded protein response sensor with a significant role in endothelial integrity and barrier function.
Saikat Fakir +3 more
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Secretopathies emerge as a new class of neurocristopathies
Developmental Dynamics, EarlyView.Abstract Neural crest cells are a transient embryonic population of cells that give rise to a wide range of structures, including craniofacial cartilage and bone, peripheral neurons and glia, as well as components of the cardiac outflow tract, among others.
Amanda Teixeira +3 more
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