Results 51 to 60 of about 111,661 (295)
Getting an UPR hand on recovERy [PDF]
Science, 2016 Cell Biology The endoplasmic reticulum (ER) is an intracellular membranous labyrinth that provides the entry point to the secretory pathway. During proteotoxic stress, the ER expands to cope with the added burden of misfolded or unfolded proteins. This is termed the unfolded protein response (UPR).
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FEBS Open Bio, EarlyView.The inhibition of mitochondrial dihydroorotate dehydrogenase (DHODH) impairs syncytialization and induces cellular senescence via mitochondrial and endoplasmic reticulum stress in human trophoblast stem cells, elevating sFlt1/PlGF levels, a hallmark of placental dysfunction in hypertensive disorders of pregnancy.
Kanoko Yoshida +6 more
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Environmental Stressors and the Unfolded Protein Response (UPR) in Exocrine Pancreatic Function
Frontiers in Physiology, 2011 The exocrine pancreas has the greatest synthetic capacity of any mammalian organ and as such is challenged with synthesis, processing and transporting a large load of digestive enzymes.
Stephen J Pandol +5 more
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FEBS Open Bio, EarlyView.Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane +11 more
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Modulation of the Unfolded Protein Response by the Human Hepatitis B Virus
Frontiers in Microbiology, 2014 During productive viral infection the host cell is confronted with synthesis of a vast amount of viral proteins which must be folded, quality controlled, assembled and secreted, perturbing the normal function of the endoplasmic reticulum (ER).
Norica eBranza-Nichita +2 more
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tRNA ligase structure reveals kinetic competition between non-conventional mRNA splicing and mRNA decay. [PDF]
, 2019 Yeast tRNA ligase (Trl1) is an essential trifunctional enzyme that catalyzes exon-exon ligation during tRNA biogenesis and the non-conventional splicing of HAC1 mRNA during the unfolded protein response (UPR).
Peschek, Jirka, Walter, Peter
core
FEBS Open Bio, EarlyView.Pharmacological inhibition of PERK in a DEN‐induced mouse model of liver cancer does not reduce tumor burden but alters cellular stress signaling. Despite blocking PERK activity, downstream stress responses, including CHOP expression, remain active, suggesting compensatory mechanisms within the unfolded protein response that may influence tumor ...
Ada Lerma‐Clavero +5 more
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Decoding Carbon Dot Purity by Nuclear Magnetic Resonance
Angewandte Chemie, EarlyView.NMR spectroscopy tracks the removal of molecular and oligomeric impurities in carbon dots, enabling a (semi)quantitative evaluation of their purity through integrated peak analysis. ABSTRACT Carbon dots (CDs) have attracted increasing attention in recent years and have been widely explored in many fields.
Yalei Hu, Alberto Bianco
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Unfolded protein response plays a critical role in heart damage after myocardial ischemia/reperfusion in rats. [PDF]
PLoS ONE, 2017 The unfolded protein response (UPR) plays a critical role in cell death mediated by ischemia/reperfusion (I/R) injury. However, little is known about the exact mechanism of UPR signaling pathways after myocardial I/R injury in rats.
Chengcheng Zhang +6 more
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The Journal of Cell Biology, 2007 A stress-coping strategy of the ER is needed in every cell cycle, show Bicknell et al. (page 1017). The ER's unfolded protein response (UPR), previously associated only with unusual or stressful conditions, is needed for the routine event of cytokinesis.
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