Results 51 to 60 of about 75,497 (305)

Periplocin and cardiac glycosides suppress the unfolded protein response

Scientific Reports, 2021
The unfolded protein response (UPR) controls protein homeostasis through transcriptional and translational regulation. However, dysregulated UPR signaling has been associated with the pathogenesis of many human diseases.
Muneshige Tokugawa, Yasumichi Inoue, Kan’ichiro Ishiuchi, Chisane Kujirai, Michiyo Matsuno, Masaki Ri, Yuka Itoh, Chiharu Miyajima, Daisuke Morishita, Nobumichi Ohoka, Shinsuke Iida, Hajime Mizukami, Toshiaki Makino, Hidetoshi Hayashi   +13 more
doaj   +1 more source

UPR Signal Activation by Luminal Sensor Domains [PDF]

, 2013
The unfolded protein response (UPR) is a cell-signaling system that detects the accumulation of unfolded protein within the endoplasmic reticulum (ER) and initiates a number of cellular responses to restore ER homeostasis.
Marta Carrara, Filippo Prischi, Prischi, F, Prischi, Filippo, Ali, Maruf, Ali, MMU, Carrara, M, Maruf Ali, Carrara, Marta   +8 more
core   +1 more source

Malectin Alleviates Endoplasmic Reticulum Stress in Gestational Diabetes Mellitus via Glycoprotein Quality Control Mechanisms

Advanced Science, EarlyView.
Malectin alleviates high glucose‐induced ER stress and damage in placental trophoblasts, a function dependent on its six critical carbohydrate‐binding residues. In a GDM mouse model, administration of TAT‐Malectin ameliorated hyperglycemia and placental ER stress and prevented fetal macrosomia.
Jiahui Zhu, Yumeng Zhang, Ye Wang, Xiaoyu Zhu, Ailin Yuan, Weijing Yin, Huangmin Yu, Xuemin Pang, Yufeng He, Yuchen Wang, Tong Wang, Yong Li, Yunlong Si   +12 more
wiley   +1 more source

The unfolded protein response is not necessary for the G1/S transition, but it is required for chromosome maintenance in Saccharomyces cerevisiae. [PDF]

PLoS ONE, 2010
BACKGROUND: The unfolded protein response (UPR) is a eukaryotic signaling pathway, from the endoplasmic reticulum (ER) to the nucleus. Protein misfolding in the ER triggers the UPR.
Kelsey A Henry, Heidi M Blank, Scott A Hoose, Michael Polymenis   +3 more
doaj   +1 more source

Propensity to endoplasmic reticulum stress in deer mouse fibroblasts predicts skin inflammation and body weight gain

Disease Models & Mechanisms, 2021
The unfolded protein response (UPR) is involved in the pathogenesis of metabolic disorders, yet whether variations in the UPR among individuals influence the propensity for metabolic disease remains unexplored. Using outbred deer mice as a model, we show
Youwen Zhang, Chang-uk Lim, Vitali Sikirzhytski, Asieh Naderi, Ioulia Chatzistamou, Hippokratis Kiaris   +5 more
doaj   +1 more source

Marburg Virus Glycoprotein Is a Remarkable Virulent Factor Linked to Hemorrhagic Pathology: Evidence from Multimodal Experimental Systems

Advanced Science, EarlyView.
By integrating data from in vitro, ex vivo, and in vivo models, our research identifies the MARV glycoprotein as a remarkable hemorrhagic factor, filling a major gap in this important field. It also provides practical experimental tools for the basic research on viral pathogenesis and applied research aimed at antiviral intervention for hemorrhagic ...
Ting Yao, Hang Liu, Yanfeng Yao, Wei Deng, Jiawen Sun, Zhenyu Kang, Ashaq Ali, Chao Shan, Zhiming Yuan, Fei Deng, Hualin Wang, Yun‐Jia Ning   +11 more
wiley   +1 more source

Compound C prevents the unfolded protein response during glucose deprivation through a mechanism independent of AMPK and BMP signaling. [PDF]

PLoS ONE, 2012
Inhibiting the unfolded protein response (UPR) can be a therapeutic approach, especially for targeting the tumor microenvironment. Here, we show that compound C (also known as dorsomorphin), a small-molecule inhibitor of AMP-activated protein kinase ...
Sakae Saito, Aki Furuno, Junko Sakurai, Hae-Ryong Park, Kazuo Shin-ya, Akihiro Tomida   +5 more
doaj   +1 more source

The effectiveness of South Africa's engagement with the universal periodic review (UPR): potential for ritualism?

, 2017
This article examines the effectiveness of South Africa’s engagement with the Human Rights Council’s Universal Periodic Review Mechanism (UPR). After two cycles of the UPR, questions on the ability of the UPR mechanism to improve the human rights ...
Damian Etone, Etone, Damian
core   +1 more source

HNRNPD Induces Radioresistance in Nasopharyngeal Carcinoma by Sequestering GRAMD4 mRNA in Stress Granules

Advanced Science, EarlyView.
HNRNPD promotes radioresistance in nasopharyngeal carcinoma by enhancing stress granule assembly and sequestering GRAMD4 mRNA. This suppresses GRAMD4 translation and inhibits mitochondrial apoptosis. Targeting the integrated stress response with ISRIB restores GRAMD4 expression and sensitizes tumors to radiotherapy, revealing a translational control ...
Yingzi Li, Tong Xiang, Yuanyuan Liu, Desheng Weng, Jingjing Zhao, Hao Chen, Yan Tang, Songzuo Xie, Hao Zhang, Jun Luo, Xinyi Yang, Qiuzhong Pan, Muping Di, Jianchuan Xia   +13 more
wiley   +1 more source

Protein misfolding and mitochondrial dysfunction in glaucoma

Frontiers in Cell and Developmental Biology
Glaucoma is a leading cause of irreversible blindness worldwide. Elevated intraocular pressure caused by restricted outflow of the aqueous humor leads to the degeneration of retinal ganglion cells (RGCs) and their axons.
Arunkumar Venkatesan, Audrey M. Bernstein, Audrey M. Bernstein   +2 more
doaj   +1 more source