Results 61 to 70 of about 75,497 (305)

Endoplasmic Reticulum Geometry Dictates Neuronal Bursting via Calcium Store Refill Rates and Exposes Selective Neuronal Vulnerability

Advanced Science, EarlyView.
The ER's continuous tubular network is maintained by ER‐shaping proteins whose mutation or dysregulation contributes to neurodegenerative diseases. Here, we show that ER morphology sets the speed of Ca2+ store replenishment between firing events. Disrupting ER continuity slows intra‐ER Ca2+ redistribution from extracellular refill (SOCE) sites, driving
Valentina Davi, Pierre Parutto, Yuyi Zhang, Tasuku Konno, Cecile Crapart, Raquel Pereira, John P. Franklin, Mosab Ali Awadelkareem, Daniel C Maddison, Michael J. Devine, Edgar R. Gomes, Joseph Chambers, Elena Koslover, Edward Avezov   +13 more
wiley   +1 more source

ZBP1 senses Brucella abortus DNA triggering type I interferon signaling pathway and unfolded protein response activation

Frontiers in Immunology
The innate immune system promptly detects and responds to invading pathogens, with a key role played by the recognition of bacterial-derived DNA through pattern recognition receptors.
Marco Túlio R. Gomes, Erika S. Guimarães, Erika S. Guimarães, Sergio C. Oliveira, Sergio C. Oliveira, Sergio C. Oliveira   +5 more
doaj   +1 more source

Analysis of the management process of doctoral training in three Cuban universities

Revista MENDIVE, 2023
Doctoral training is the integrating nucleus not only of substantive university processes (teaching, research and extension) but also of the different forms of postgraduate and guarantor of university quality and, especially, of higher education ...
Tania Vargas Fernández, Mayra Ordaz Hernández, Luis Gustavo Marín Cuba, Maricela María González Pérez   +3 more
doaj  

Molecularly defined unfolded protein response subclasses have distinct correlations with fatty liver disease in zebrafish

Disease Models & Mechanisms, 2014
The unfolded protein response (UPR) is a complex network of sensors and target genes that ensure efficient folding of secretory proteins in the endoplasmic reticulum (ER). UPR activation is mediated by three main sensors, which regulate the expression of
Ana M. Vacaru, Antonio Fabio Di Narzo, Deanna L. Howarth, Orkhontuya Tsedensodnom, Dru Imrie, Ayca Cinaroglu, Salma Amin, Ke Hao, Kirsten C. Sadler   +8 more
doaj   +1 more source

Caveolin‐1 Stabilizes SERCA2 to Counteract Acute Kidney Injury via Suppression of Ca2+‐Dependent Endoplasmic Reticulum Stress in Distal Tubules

Advanced Science, EarlyView.
In AKI, initial kidney injury upregulates the expression of Cav‐1, which subsequently binds to and stabilizes SERCA2 via its scaffolding domain and through deubiquitination, thereby regulating Ca2+ homeostasis and ER stress. Conversely, Cav‐1 deficiency accelerates SERCA2 degradation, triggering Ca2+ overload and ER stress, and ultimately exacerbating ...
Yan Zhang, Xin He, Hao Huang, Rong Lu, Xin Lv, Shenglan Li, Sijue Zou, Jiawei Cheng, Yiwei Xiong, Zhenghao Deng, Qiongjing Yuan, Yanyun Xie, Ling Huang, Jiaxi Pu, Shao Liu, Qianbin Li, Jie Meng, Huixiang Yang, Lijian Tao, Zhangzhe Peng   +19 more
wiley   +1 more source

Empowering Civil Society Organisations at the UPR - Strengthening Implementation of Recommendations from the UN's Universal Periodic Review [PDF]

The aim of this study is to empower civil society organisations whenengaging with the UPR, in turn strengthening the domestic implementationof UPR recommendations.
Oleschuk, Melisa, Storey, Alice
core   +1 more source

Inhomogeneous spatial distribution of the magnetic transition in an iron-rhodium thin film

Nature Communications, 2017
Films of iron-rhodium alloy undergo a magnetic transition at 100°C, and so are attractive for applications, but a detailed understanding of the transition mechanism has not been achieved.
C. Gatel, B. Warot-Fonrose, N. Biziere, L.A. Rodríguez, D. Reyes, R. Cours, M. Castiella, M.J. Casanove   +7 more
doaj   +1 more source

Study of Dissolved Organic Carbon Concentration in KHDTK Forest Peatland Area, Central Kalimantan, Indonesia

, 2021
The study was conducted to determine whether are differences in dissolved organic carbon (DOC) in three different types of peatland conditions. The study was conducted from March 1st to April 30, 2020.
Pratama, Galih Widhi, Adji, Fengky F., Surawijaya, Panji, Yulianti, Nina, Damanik, Zafrullah   +4 more
core  

A Viscous DES‐AAV‐Foxo1 Delivery System With High Transfection Efficiency for the Treatment of Corneal Endothelial Dysfunction by Restoring Mitochondria‐ER Contacts

Advanced Science, EarlyView.
High glucose triggers corneal endothelial dysfunction by impairing FOXO1‐mediated ITPR1 transcription, leading to disrupted mitochondria‐associated membrane (MAM) integrity and defective ER‐to‐mitochondria Ca2+ transfer. This study develops an innovative viscous DES‐AAV‐Foxo1 delivery system with enhanced transfection efficiency. This non‐invasive gene
Hongran Zhao, Xiaoyu Li, Hongwei Wang, Zongyi Li, Qun Wang, Yangyang Zhang, Xu Jing, Xia Qi, Qingjun Zhou, Shengqian Dou, Lixin Xie   +10 more
wiley   +1 more source

ER biogenesis without stress: how the ribosome receptor, p180, defines a developmental program beyond the UPR

Frontiers in Cell and Developmental Biology
The endoplasmic reticulum (ER) plays a central role in protein and lipid biosynthesis, quality control, and secretion. While its functional roles are well characterized, the mechanisms underlying ER biogenesis remain less defined.
Payam Benyamini, David I. Meyer
doaj   +1 more source