Results 81 to 90 of about 111,661 (295)
Disease Models & Mechanisms, 2014 The unfolded protein response (UPR) is a complex network of sensors and target genes that ensure efficient folding of secretory proteins in the endoplasmic reticulum (ER). UPR activation is mediated by three main sensors, which regulate the expression of
Ana M. Vacaru +8 more
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Endoplasmic reticulum stress, degeneration of pancreatic islet β-cells, and therapeutic modulation of the unfolded protein response in diabetes. [PDF]
, 2019 BackgroundMyriad challenges to the proper folding and structural maturation of secretory pathway client proteins in the endoplasmic reticulum (ER) - a condition referred to as "ER stress" - activate intracellular signaling pathways termed the unfolded ...
Colon-Negron, Kevin +2 more
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The endoplasmic reticulum in plant immunity and cell death [PDF]
, 2012 The endoplasmic reticulum (ER) is a highly dynamic organelle in eukaryotic cells and a major production site of proteins destined for vacuoles, the plasma membrane, or apoplast in plants.
Eichmann, Ruth, Schäfer, P. (Patrick)
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The mitochondrial UPR – protecting organelle protein homeostasis [PDF]
Journal of Cell Science, 2010 Mitochondria are required for numerous essential metabolic processes including the regulation of apoptosis; therefore, proper maintenance of the mitochondrial proteome is crucial. The protein-folding environment in mitochondria is challenged by organelle architecture, the presence of reactive oxygen species and the difficulties associated with assembly
Cole M, Haynes, David, Ron
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Advanced Science, EarlyView.The ER's continuous tubular network is maintained by ER‐shaping proteins whose mutation or dysregulation contributes to neurodegenerative diseases. Here, we show that ER morphology sets the speed of Ca2+ store replenishment between firing events. Disrupting ER continuity slows intra‐ER Ca2+ redistribution from extracellular refill (SOCE) sites, driving
Valentina Davi +13 more
wiley +1 more source
Analysis of the management process of doctoral training in three Cuban universities
Revista MENDIVE, 2023 Doctoral training is the integrating nucleus not only of substantive university processes (teaching, research and extension) but also of the different forms of postgraduate and guarantor of university quality and, especially, of higher education ...
Tania Vargas Fernández +3 more
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STING-mediated disruption of calcium homeostasis chronically activates ER stress and primes T cell death [PDF]
, 2019 STING gain-of-function mutations cause lung disease and T cell cytopenia through unknown mechanisms. Here, we found that these mutants induce chronic activation of ER stress and unfolded protein response (UPR), leading to T cell death by apoptosis in ...
Chen, Yu-Ju +6 more
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TXNIP Switches Tracks toward a Terminal UPR [PDF]
Cell Metabolism, 2012 During the progression of diabetes, crosstalk between ER stress and inflammation controls islet cell fate. In this issue, Lerner et al. (2012) and Oslowski et al. (2012) discover that thioredoxin-interacting protein (TXNIP) is a regulatory switch connecting the terminal unfolded protein response (UPR) and NLRP3 inflammasome to mediate β cell death.
Anthony, Tracy G., Wek, Ronald C.
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Advanced Science, EarlyView.This review surveys nanoparticle‐based strategies to enhance adoptive cell therapy, particularly CAR‐T cell approaches, in solid tumor treatment. It describes how nanoparticles can improve tumor immunogenicity and T‐cell infiltration while reducing toxicity, and how they enable in vivo CAR‐T cell generation.
Erica Frostegård +19 more
wiley +1 more source
Frontiers in Cell and Developmental BiologyThe endoplasmic reticulum (ER) plays a central role in protein and lipid biosynthesis, quality control, and secretion. While its functional roles are well characterized, the mechanisms underlying ER biogenesis remain less defined.
Payam Benyamini, David I. Meyer
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