Results 81 to 90 of about 75,497 (305)

Mechanistic investigation of Liujing Toutong tablet in the treatment of cerebral ischemia–reperfusion injury in rats by the integration of serum pharmacochemistry and metabolomics

Animal Models and Experimental Medicine, EarlyView.
The research strategy for pharmacodynamics, serum pharmacochemistry, metabolomics, and network pharmacology analysis method in intervention effects of LTT are illustrated. Abstract Background Liujing Toutong tablet (LTT) is a traditional Chinese patent medicine.
Zihan Yu, Ke Pei, Xiulin Wang, Wenling Li, Hongchang Li, Wangyang Xie, Xianglong Meng, Tingting Zhao, Yan Ning, Haixin Liu, Wenbin He   +10 more
wiley   +1 more source

ATF6 inhibition suppresses the protective effects of pasireotide in human and bovine endothelial cells

Vascular Biology
Activating transcription factor 6 (ATF6) is an unfolded protein response sensor with a significant role in endothelial integrity and barrier function.
Saikat Fakir, Md Matiur Rahman Sarker, Madan Sigdel, Nektarios Barabutis   +3 more
doaj   +1 more source

Endoplasmic reticulum stress and the unfolded protein response in lung diseases: molecular pathways and therapeutic interventions. [PDF]

J Pathol
Abstract Endoplasmic reticulum stress (ERS) occurs when the protein‐folding capacity of the endoplasmic reticulum (ER) is overwhelmed, triggering the unfolded protein response (UPR) to restore homeostasis. However, severe or persistent ERS can shift the UPR toward pro‐inflammatory, apoptotic, and fibrotic signaling, thereby exacerbating tissue injury ...
Song L, Liu Y, Xu C, Zhang Y, Xu K, Yao D, Huang X.   +6 more
europepmc   +2 more sources

CRISPR-Based Gene Dependency Screens Reveal Mechanism of BRAF Inhibitor Resistance in Anaplastic Thyroid Cancer. [PDF]

Mol Carcinog
ABSTRACT Anaplastic thyroid cancer (ATC) is the most aggressive form of thyroid cancer. Despite recent advances in treating BRAFV600E‐driven ATC, therapy resistance remains a significant challenge, often resulting in disease progression and death.
Noronha S, Liu Y, Geneti G, Li H, Wu X, Sun D, Gujar V, Furusawa T, Lobanov A, Cam M, Pal LR, Nair NU, Day CP, Ruppin E, Ghosh C, Hu J, Ramamoorthy B, Kumar S, Andresson T, Chan K, O'Neill M, Chari R, Pommier Y, Rivero JD, Weyemi U, Kebebew E, Boufraqech M.   +26 more
europepmc   +2 more sources

Indole‐3‐Acetic Acid Protects Bovine Hepatocytes Against Palmitic Acid‐Induced Lipid Accumulation and ER Stress Through SIRT3

Animal Research and One Health, EarlyView.
Cows with ketosis during the perinatal period often experience damage to the liver, a core metabolic organ, thereby exacerbating the disease's inherent vicious cycle. This study indicates that serum 3‐IAA concentrations were reduced in ketotic cows and show a significant negative correlation with hepatic TG content.
Dandan Qi, Chenchen Zhao, Guiying Li, Jinxia Li, Menglin Liu, Fanrong Kong, Enzhu Li, Jie Gao, Wenqi Liao, Akos Kenez, Wenwen Gao, Yuxiang Song, Xiliang Du, Guowen Liu, Xinwei Li, Lin Lei   +15 more
wiley   +1 more source

ANALISIS FAKTOR PENENTU DALAM PEMILIHAN STRATEGI PROMOSI UNIVERSITAS PALANGKA RAYA

, 2023
Penelitian mengenai analisis faktor penentu dalam pemilihan strategi promosi Universitas Palangka Raya (UPR) bertujuan untuk mengetahui kelebihan, kekurangan, peluang, dan acaman melalui analisis SWOT sehingga diketahui strategi dalam meningkatkan ...
Maya Mustika, Erni Dwi Puji Setyowati, Ahriyati, Nirena Ade Christy   +3 more
core  

Cationic Permethylated Cyclodextrins Capable of Self‐Assembling Into Linear Nanostructures in Water

Chemistry – A European Journal, EarlyView.
A quaternary ammonium bridge equipped with a lipophilic substituent in permethylated cyclodextrins suppresses undesired supramolecular interactions and promotes controlled, directional head‐to‐tail self‐assembly into well‐defined linear nanostructures.
Maxime Kolb, Marvin Benjaffel, Peter Faller, Laurent Raibaut, Dominique Armspach   +4 more
wiley   +1 more source

Recent Insights into the Role of Unfolded Protein Response in ER Stress in Health and Disease

Frontiers in Cell and Developmental Biology, 2017
Unfolded stress response (UPR) is a conserved cellular pathway involved in protein quality control to maintain homeostasis under different conditions and disease states characterized by cell stress.
Dan Lindholm, Dan Lindholm, Laura Korhonen, Laura Korhonen, Ove Eriksson, Sulev Kõks, Sulev Kõks   +6 more
doaj   +1 more source

The ER Morphologically Changes during the UPR

, 2013
(A) Control cells and UPR-induced cells were used to analyze and follow the ER within a single cell using EM. Boxes indicate the areas magnified in (B).
Kent L McDonald (66699), Peter Walter (4403), Sebastián Bernales (4402)   +2 more
core   +1 more source

Novel Organelle‐Based Intracellular Immunity With Mechanistic and Therapeutic Implications

Barrier Immunity, EarlyView.
A conceptual framework illustrating how PAMPs/DAMPs initiate barrier, innate, adaptive, and intracellular immune responses, with organelle‐based intracellular immunity serving as a central integrator linking metabolism, inflammatory signaling, and therapeutic interventions to restore immune homeostasis.
Keman Xu, Shih‐Yu Hung, Fatma Saaoud, Ying Shao, Yifan Lu, Juanjuan Liu, Bo Yuan, Haiyan Xiang, Hong Wang, Xiaofeng Yang   +9 more
wiley   +1 more source