Results 91 to 100 of about 101,011 (227)

Guardians Under Siege: Civil Society Access and Reform of the UN Human Rights Council

Global Policy, EarlyView.
ABSTRACT This article examines how restrictions on civil society participation at the United Nations Human Rights Council (UNHRC) undermine the institution's effectiveness. Through stakeholder interviews and analysis of recent developments, we show that civil society engagement does not merely fulfil a democratic aspiration, but it is an operational ...
Inés M. Pousadela, Samuel King
wiley   +1 more source

Emerging mechanisms of the unfolded protein response in therapeutic resistance: from chemotherapy to Immunotherapy

Cell Communication and Signaling
The accumulation of unfolded or misfolded proteins in the endoplasmic reticulum (ER) causes ER stress and activates the unfolded protein response (UPR). As an adaptive cellular response to hostile microenvironments, such as hypoxia, nutrient deprivation,
Jiang He, You Zhou, Lunquan Sun
doaj   +1 more source

Predicting global habitat suitability and invasion risks of the red gum lerp psyllid Glycaspis brimblecombei under current and future climates

Agricultural and Forest Entomology, EarlyView.
Ecological niche modelling identified highly suitable habitats for Glycaspis brimblecombei across tropical, subtropical and temperate regions. Future climate projections indicate a moderate contraction of suitable areas, with persistence of core climatic suitability. Model performance was robust (AUC = 0.880; TSS = 0.634; CBI = 0.803), with temperature
Fernanda de Aguiar Coelho, George Corrêa Amaro, Adriene Caldeira Batista, Edmond Joseph Djibril Victor Barry, Muhammad Haseeb, Marcus Alvarenga Soares, Owusu Fordjour Aidoo, Sebastião Lourenço de Assis Júnior, Ricardo Siqueira da Silva   +8 more
wiley   +1 more source

Can UPR integrate fasting and stem cell regeneration?

Frontiers in Chemistry, 2015
Ruchi eChaube
doaj   +1 more source

sUPRa is a dual-color reporter for unbiased quantification of the unfolded protein response with cellular resolution

Scientific Reports
The unfolded protein response (UPR) maintains proteostasis upon endoplasmic reticulum (ER) stress, and is initiated by a range of physiological and pathological processes.
Atreyi Chakrabarty, Sarah E. Newey, Maisha M. Promi, Belinda K. Agbetiameh, Daniella Munro, Paul J. N. Brodersen, Gemma Gothard, Kashif Mahfooz, Jose P. Mengual, Vladyslav V. Vyazovskiy, Colin J. Akerman   +10 more
doaj   +1 more source

Distinct Skin Penetration and Immune Responses to Ionic and Nanoparticulate Cobalt in Allergic Contact Dermatitis

Allergy, EarlyView.
Cobalt chloride (CoCl2) and cobalt nanoparticles (CoNPs) induce a shared, severity‐dependent inflammatory response in cobalt‐sensitized skin characterized by activation of interferon signaling, inflammatory pathways (TNF/NF‐κβ, IL6‐STAT3), apoptosis/UPR, cell cycle programs, and glycolysis.
Paulina Werner, Martin Schaier, Gabriel Braun, Anneli Julander, Klara Midander, Marlene Isaksson, Gunda Koellensperger, Lukas Wisgrill, Nanna Fyhrquist   +8 more
wiley   +1 more source

The ER Morphologically Changes during the UPR

, 2013
(A) Control cells and UPR-induced cells were used to analyze and follow the ER within a single cell using EM. Boxes indicate the areas magnified in (B).
Kent L McDonald (66699), Peter Walter (4403), Sebastián Bernales (4402)   +2 more
core   +1 more source

A quad‐cistronic fluorescent biosensor system for real‐time detection of subcellular Ca2+ signals

British Journal of Pharmacology, EarlyView.
Background and Purpose The calcium ion (Ca2+) is a versatile cellular messenger regulating a variety of biological processes. Compounds modulating subcellular Ca2+ signals hold substantial pharmacological potential. Advances in fluorescent biosensors have revolutionised Ca2+ imaging.
Anna Lischnig, Yusuf C. Erdoğan, Benjamin Gottschalk, Michael Gruber, Andrea Groselj‐Strele, Sandra Burgstaller, Wolfgang F. Graier, Roland Malli   +7 more
wiley   +1 more source

A Year at the Forefront of Proteostasis and Aging

Biology Open, 2023
Maximilian A. Thompson, Evandro A. De-Souza   +1 more
doaj   +1 more source

References to UN entities in UPR Recommendations

The data in this spreadsheet includes recommendations made during the first three cycles of the Human Rights Council's UPR. For the first two cycles of UPR, the data was taken from the database created by UPR-Info.
Shah, Sangeeta
core   +1 more source