Results 111 to 120 of about 111,661 (295)
Chan–Lam Cross‐Coupling With Alkylboron Reagents: From Transmetallation to Radical Pathways
European Journal of Organic Chemistry, EarlyView.Alkylative Chan–Lam coupling overcomes intrinsic transmetallation limitations of alkylboron reagents by engaging radical pathways. Recent advances reveal how radical and radical–polar crossover mechanisms enable mild C(sp3)—heteroatom bond formation. This minireview highlights key mechanistic insights and emerging strategies that transform alkylboron ...
Nicolas G.‐Simonian +3 more
wiley +1 more source
Endothelial cells, endoplasmic reticulum stress and oxysterols [PDF]
, 2017 Oxysterols are bioactive lipids that act as regulators of lipid metabolism, inflammation, cell viability and are involved in several diseases, including atherosclerosis.
Canonico, B. +10 more
core +3 more sources
European Journal of Organic Chemistry, EarlyView.A set of 3‐sulfonyl‐azaspiro[4.5]trienones have been obtained via a metal‐ and photocatalyst‐free visible‐light‐driven dearomative strategy. The protocol exploits arylazo sulfones, which act simultaneously as the light absorber and sulfonyl‐radical source, enabling ipso‐spirocyclization of differently substituted N‐aryl propiolamides.
Luca Nicchio +5 more
wiley +1 more source
Recent Insights into the Role of Unfolded Protein Response in ER Stress in Health and Disease
Frontiers in Cell and Developmental Biology, 2017 Unfolded stress response (UPR) is a conserved cellular pathway involved in protein quality control to maintain homeostasis under different conditions and disease states characterized by cell stress.
Dan Lindholm +6 more
doaj +1 more source
The transcription factor ATF5: role in cellular differentiation, stress responses, and cancer. [PDF]
, 2017 Activating transcription factor 5 (ATF5) is a cellular prosurvival transcription factor within the basic leucine zipper (bZip) family that is involved in cellular differentiation and promotes cellular adaptation to stress.
Angelastro, James M, Sears, Thomas K
core +2 more sources
Food Safety and Health, EarlyView.Heat‐stressed soybeans adapt to elevated temperatures through coordinate regulation of destructive and protective protein expression ‐ suppressing detrimental proteins while enhancing beneficial ones. ABSTRACT Soybean represents the largest imported agricultural product in China. Imported soybeans are typically transported via maritime shipping. During
Pengdi Ding +5 more
wiley +1 more source
Nature Communications, 2020 Developing novel thermometry techniques for nanoscale temperature measurements are vital for realizing efficient thermal management of nanoscale devices.
Karl Ridier +7 more
doaj +1 more source
The role of the Amyloid Precursor Protein mutations and PERK-dependent signaling pathways in the pathogenesis of Alzheimer’s disease [PDF]
, 2016 Alzheimer’s disease (AD) is a highly complex, progressive, age-related neurodegenerative human disease entity. The genetic basis of AD is strictly connected with occurrence of mutations in Amyloid Precursor (APP) gene on chromosome 21.
Diehl, J. Alan +5 more
core +2 more sources
Grassland Research, EarlyView.Herbaceous plant recovery following shrub clearing and reseeding in the rangelands of Peddie, Eastern Cape of South Africa. CTL, control; CO, cutting only; CR, cutting and reseeding; UPO, uprooting only; UPR, uprooting and reseeding. Abstract Background Shrub encroachment (SE) drives rangeland degradation, threatening biodiversity and forage ...
Monelisi Makanya +3 more
wiley +1 more source
The unfolded protein response in multiple sclerosis
Frontiers in Neuroscience, 2015 The unfolded protein response (UPR) occurs in response to endoplasmic reticulum (ER) stress caused by the accumulation of unfolded or misfolded proteins in the ER.
Wensheng eLin, Sarrabeth eStone
doaj +1 more source