Results 111 to 120 of about 75,497 (305)

Repurposing peripheral immunocytes of Bacillus Calmette Guerin-vaccinated melanoma patients to reveal preventive Alzheimer's disease mechanisms, possibly via the unfolded protein response

Journal of Alzheimer's Disease Reports
Background Alzheimer's disease (AD) dysfunctional unfolded protein response (UPR) is revealed by amyloid-β aggregates. Normally, UPR reacts to endoplasmic reticulum stress by resolving misfolded/aggregated proteins, and UPR failure induces brain-cell ...
Benjamin Y Klein, Inna Ben-David, Ofer N Gofrit, Charles L Greenblatt   +3 more
doaj   +1 more source

References to UN entities in UPR Recommendations

The data in this spreadsheet includes recommendations made during the first three cycles of the Human Rights Council's UPR. For the first two cycles of UPR, the data was taken from the database created by UPR-Info.
Shah, Sangeeta
core   +1 more source

Bisphenol Analog‐Induced Cytotoxicity: Unraveling Endoplasmic Reticulum (ER) Stress and Apoptotic Pathways

Journal of Applied Toxicology, EarlyView.
ABSTRACT Bisphenol A (BPA) is increasingly replaced by structural analogs, yet their safety remains insufficiently characterized. This study investigated whether BPA and selected analogs, bisphenol AF (BPAF), bisphenol AP (BPAP), bisphenol P (BPP), and bisphenol E (BPE), induce cytotoxicity through activation of endoplasmic reticulum (ER) stress and ...
Rafia Afroze Rifa, Ramon Lavado
wiley   +1 more source

Comprehensive assessment of unfolded protein response and its association with tumor progression in pan‐cancer

iMetaOmics
Disruption of proteostasis in the endoplasmic reticulum leads to the activation of the unfolded protein response (UPR). UPR activation is common in malignant cells and is often considered a contributor to cancer progression.
Xinyu Yang, Faming Zhao, Jing Yang, Xinran Xia, Liwei Chen, Peng Zeng, Liang Chen, Yanxia Hu, Xia Sheng   +8 more
doaj   +1 more source

Training for Legal Professionals in The Gambia on the Universal Periodic Review

The workshop is organized with the support of Dr Michael Lane (University of Worcester, UK) and Dr Frederick Cowell (Birkbeck, University of London, UK).
Cowell, F., Lane, Michael
core  

Humanism in the Age of Hyperreality: A Speculative Critique of AI Therapybots and the Neoliberal Commodification of Human Beings

The Journal of Humanistic Counseling, EarlyView.
ABSTRACT This article examines the future place of humanistic counseling, assuming the successful mass deployment of artificial intelligence therapy chatbots (AITCs). We systematically identify the limitations of AITCs through the lens of Jean Baudrillard's view on simulacra and hyperreality and identify five collective psychosocial consequences of ...
Brett. D. Wilkinson, Andrew M. Brown
wiley   +1 more source

A Bioluminescent Reporter System for Real-Time Monitoring of the Unfolded Protein Response in Plants. [PDF]

Plant Biotechnol J
ABSTRACT The unfolded protein response (UPR) is a critical mechanism for maintaining endoplasmic reticulum (ER) homeostasis under stress. Here, we developed a bioluminescent reporter system, AtbZIP60‐LUC, in Arabidopsis to dynamically monitor ER stress by coupling IRE1‐mediated splicing of bZIP60 mRNA to firefly luciferase (LUC) expression.
Liu Y, Niu Y, Zhao Y, Zhang W, Lv Y, Liu M, Zhang Q, Wang J, Zhang X, Li Y, Zhang H, Zhang Y, Bao Y.   +12 more
europepmc   +2 more sources

Differential UPR Target Gene Induction by Elevated Hac1p Levels

, 2013
(A) Comparison of UPR target gene induction under either UPR or S-UPR conditions. Whole-genome mRNA expression analysis was carried out on WT cells harvested after 60 min of treatment, either grown at 30 °C and treated with 6 mM DTT (x-axis), or grown at
Peter Walter (4403), Jess H Leber (4401), Sebastián Bernales (4402)   +2 more
core   +1 more source

More than proteins for empty stomachs: Wild meat in the BaTonga food system

People and Nature, EarlyView.
Abstract Our paper highlights the limitations of the framework used by many conservation‐focused programmes that incorporate food security objectives. This framework encourages the substitution of wild proteins with domestic proteins by promoting animal farming in communities located near conservation areas.
Muriel Figuié, Luzibo Ottilia Munsaka, Vupenyu Dzingirai, Olivier Lepiller, Maxwell Phiri, Patrice Grimaud   +5 more
wiley   +1 more source

Fluorescence Visualization of an ER Marker after UPR Induction

, 2013
(A) Cells treated with the UPR-inducing drug DTT (+DTT) or with no drug were visualized using a fusion protein between the translocon component Sec61 and the red-fluorescent protein “cherry.” Top panels show untreated cells, and bottom panels show ...
Kent L McDonald (66699), Peter Walter (4403), Sebastián Bernales (4402)   +2 more
core   +1 more source