Results 121 to 130 of about 75,497 (305)

The dynamics of wild and alternative meat consumption across Gabon, Central Africa

People and Nature, EarlyView.
Abstract Long‐term overharvesting of wild animals for their meat threatens wildlife and the people dependent on wild animal meat for their diets and incomes. Interventions to reduce wild meat consumption must be built upon a complete understanding of the roles of wild meat and its alternatives within food systems.
Joshua Bauld, Lauren Coad, Robin C. Whytock, Donald Midoko Iponga, Margeorie Babicka, Sophie Pambo, Paul Loundou, Daniel J. Ingram, Kathryn Jeffery, Mattia Bessone, David S. Wilkie, Malcolm Starkey, Steeve Ngama, Daniel Cornelis, Katharine A. Abernethy   +14 more
wiley   +1 more source

Emerging mechanisms of the unfolded protein response in therapeutic resistance: from chemotherapy to Immunotherapy

Cell Communication and Signaling
The accumulation of unfolded or misfolded proteins in the endoplasmic reticulum (ER) causes ER stress and activates the unfolded protein response (UPR). As an adaptive cellular response to hostile microenvironments, such as hypoxia, nutrient deprivation,
Jiang He, You Zhou, Lunquan Sun
doaj   +1 more source

Extensive but fragmented evidence limits understanding of factors shaping farmers' decisions regarding diversified farming systems: A global evidence map

People and Nature, EarlyView.
Abstract Diversified farming systems are increasingly recognised for their potential to enhance the sustainability and resilience of food systems. Yet it remains unclear whether empirical research adequately captures the drivers and constraints shaping farmers' decisions regarding diversified farming systems across stages of decision‐making ...
Andrea C. Sánchez Bogado, Damien Beillouin, Natalia Estrada‐Carmona, Cécile Chéron‐Bessou, Bruno Rapidel, Sarah K. Jones   +5 more
wiley   +1 more source

The Transcription Factor ATF5 Mediates a Mammalian Mitochondrial UPR

, 2017
Mitochondrial dysfunction is pervasive in human pathologies such as neurodegeneration, diabetes, cancer, and pathogen infections as well as during normal aging.
Pellegrino, Mark W., Rosin, Nadine, Lin, Yi-Fan, Haynes, Cole M, Fiorese, Christopher J., Schulz, Anna M.   +5 more
core   +1 more source

Hemophilia A: An Ideal Disease for Prenatal Therapy

Prenatal Diagnosis, EarlyView.
ABSTRACT Hemophilia A (HA) is the most common inherited coagulation defect. Current state‐of‐the‐art treatment consists of frequent administration of prophylactic infusions of coagulation factor VIII (FVIII) protein or bispecific antibodies that replace the cofactor function of FVIIIa to maintain hemostasis. However, these treatments are far from ideal,
Christopher D. Porada, Anthony Atala, Graça Almeida‐Porada   +2 more
wiley   +1 more source

Can UPR integrate fasting and stem cell regeneration?

Frontiers in Chemistry, 2015
Ruchi eChaube
doaj   +1 more source

sUPRa is a dual-color reporter for unbiased quantification of the unfolded protein response with cellular resolution

Scientific Reports
The unfolded protein response (UPR) maintains proteostasis upon endoplasmic reticulum (ER) stress, and is initiated by a range of physiological and pathological processes.
Atreyi Chakrabarty, Sarah E. Newey, Maisha M. Promi, Belinda K. Agbetiameh, Daniella Munro, Paul J. N. Brodersen, Gemma Gothard, Kashif Mahfooz, Jose P. Mengual, Vladyslav V. Vyazovskiy, Colin J. Akerman   +10 more
doaj   +1 more source

PAO1 induces the ISR and UPR

, 2015
Online repository data of manuscript "PAO1 induces the ISR and UPR".
Emily Van 't wout (719365)
core   +1 more source

Noise‐Induced Hearing Loss: From Pathological Mechanisms to Therapeutic Interventions

Sensory Neuroscience, EarlyView.
ABSTRACT Noise‐induced hearing loss (NIHL), a significant non‐genetic form of hearing impairment, is primarily managed through the use of hearing aids and cochlear implants. However, the fundamental pathological mechanisms underlying NIHL remain inadequately addressed.
Shiqi Huang, Yu Xiao, Jiaxin Liu, Wen Jiang, Weiwei Shi, Hanbing Zhang, Xiaolong Fu, Yunhao Wu   +7 more
wiley   +1 more source

A Year at the Forefront of Proteostasis and Aging

Biology Open, 2023
Maximilian A. Thompson, Evandro A. De-Souza   +1 more
doaj   +1 more source