Results 121 to 130 of about 111,661 (295)

Facilitating a ‘non-judgmental’ skills-based co-design environment [PDF]

, 2015
This paper reflects on a pilot study for the design of a series of e-textiles workshops developed for the Nottinghamshire Mind Network community of mental health and wellbeing service users, managers and volunteers. The final workshops will form part of ‘
Bates, M, Glazzard, M, Kettley, R, Kettley, S, Lucas, R, Walker, S   +5 more
core   +1 more source

The Effects of Angiotensin Receptor Neprilysin Inhibitor on Endoplasmic Reticulum Stress in Doxorubicin‐Mediated Cardiomyopathy‐Associated Heart Failure Model in Rats

Journal of Applied Toxicology, EarlyView.
ABSTRACT One of the most serious complications associated with the use of the chemotherapeutic agent doxorubicin (DOX) is cardiomyopathy. Although cardioprotective drugs such as angiotensin receptor‐neprilysin inhibitors (ARNI) are used to prevent cardiomyopathy in DOX patients, no studies have reported the relationship between ARNI and endoplasmic ...
Mert Unvan, Meryem İlkay Karagül, Hatice Oruç Demirbağ, Ebru Balli   +3 more
wiley   +1 more source

CRISPR‐Based Gene Dependency Screens Reveal Mechanism of BRAF Inhibitor Resistance in Anaplastic Thyroid Cancer

Molecular Carcinogenesis, EarlyView.
ABSTRACT Anaplastic thyroid cancer (ATC) is the most aggressive form of thyroid cancer. Despite recent advances in treating BRAFV600E‐driven ATC, therapy resistance remains a significant challenge, often resulting in disease progression and death.
Shawn Noronha, Yue Liu, Gaga Geneti, Haojian Li, Xiaolin Wu, David Sun, Vaibhavi Gujar, Takashi Furusawa, Alexei Lobanov, Maggie Cam, Lipika R. Pal, Nishanth U. Nair, Chi‐Ping Day, Eytan Ruppin, Chandrayee Ghosh, Jiangnan Hu, Bhavishya Ramamoorthy, Suresh Kumar, Thorkell Andresson, King Chan, Maura O'Neill, Raj Chari, Yves Pommier, Jaydira Del Rivero, Urbain Weyemi, Electron Kebebew, Myriem Boufraqech   +26 more
wiley   +1 more source

More than proteins for empty stomachs: Wild meat in the BaTonga food system

People and Nature, EarlyView.
Abstract Our paper highlights the limitations of the framework used by many conservation‐focused programmes that incorporate food security objectives. This framework encourages the substitution of wild proteins with domestic proteins by promoting animal farming in communities located near conservation areas.
Muriel Figuié, Luzibo Ottilia Munsaka, Vupenyu Dzingirai, Olivier Lepiller, Maxwell Phiri, Patrice Grimaud   +5 more
wiley   +1 more source

Comprehensive assessment of unfolded protein response and its association with tumor progression in pan‐cancer

iMetaOmics
Disruption of proteostasis in the endoplasmic reticulum leads to the activation of the unfolded protein response (UPR). UPR activation is common in malignant cells and is often considered a contributor to cancer progression.
Xinyu Yang, Faming Zhao, Jing Yang, Xinran Xia, Liwei Chen, Peng Zeng, Liang Chen, Yanxia Hu, Xia Sheng   +8 more
doaj   +1 more source

The dynamics of wild and alternative meat consumption across Gabon, Central Africa

People and Nature, EarlyView.
Abstract Long‐term overharvesting of wild animals for their meat threatens wildlife and the people dependent on wild animal meat for their diets and incomes. Interventions to reduce wild meat consumption must be built upon a complete understanding of the roles of wild meat and its alternatives within food systems.
Joshua Bauld, Lauren Coad, Robin C. Whytock, Donald Midoko Iponga, Margeorie Babicka, Sophie Pambo, Paul Loundou, Daniel J. Ingram, Kathryn Jeffery, Mattia Bessone, David S. Wilkie, Malcolm Starkey, Steeve Ngama, Daniel Cornelis, Katharine A. Abernethy   +14 more
wiley   +1 more source

Repurposing peripheral immunocytes of Bacillus Calmette Guerin-vaccinated melanoma patients to reveal preventive Alzheimer's disease mechanisms, possibly via the unfolded protein response

Journal of Alzheimer's Disease Reports
Background Alzheimer's disease (AD) dysfunctional unfolded protein response (UPR) is revealed by amyloid-β aggregates. Normally, UPR reacts to endoplasmic reticulum stress by resolving misfolded/aggregated proteins, and UPR failure induces brain-cell ...
Benjamin Y Klein, Inna Ben-David, Ofer N Gofrit, Charles L Greenblatt   +3 more
doaj   +1 more source

Endoplasmic reticulum stress and the unfolded protein response in lung diseases: molecular pathways and therapeutic interventions

The Journal of Pathology, EarlyView.
Abstract Endoplasmic reticulum stress (ERS) occurs when the protein‐folding capacity of the endoplasmic reticulum (ER) is overwhelmed, triggering the unfolded protein response (UPR) to restore homeostasis. However, severe or persistent ERS can shift the UPR toward pro‐inflammatory, apoptotic, and fibrotic signaling, thereby exacerbating tissue injury ...
Lanlan Song, Yichen Liu, Chen Xu, Yaochen Zhang, Kaiming Xu, Dan Yao, Xiaoying Huang   +6 more
wiley   +1 more source

Hemophilia A: An Ideal Disease for Prenatal Therapy

Prenatal Diagnosis, EarlyView.
ABSTRACT Hemophilia A (HA) is the most common inherited coagulation defect. Current state‐of‐the‐art treatment consists of frequent administration of prophylactic infusions of coagulation factor VIII (FVIII) protein or bispecific antibodies that replace the cofactor function of FVIIIa to maintain hemostasis. However, these treatments are far from ideal,
Christopher D. Porada, Anthony Atala, Graça Almeida‐Porada   +2 more
wiley   +1 more source

Pancreatic adaptive responses in alcohol abuse: Role of the unfolded protein response. [PDF]

, 2015
The majority of those who drink excessive amounts of alcohol do not develop pancreatic disease. One overarching hypothesis is that alcohol abuse requires additional risk factors, either environmental or genetic, for disease to occur.
Lugea, Aurelia, Pandol, Stephen J, Waldron, Richard T   +2 more
core   +1 more source