Results 101 to 110 of about 75,497 (305)
eLife, 2017 Insufficient folding capacity of the endoplasmic reticulum (ER) activates the unfolded protein response (UPR) to restore homeostasis. Yet, how the UPR achieves ER homeostatic readjustment is poorly investigated, as in most studies the ER stress that is ...
Anush Bakunts +9 more
doaj +1 more source
A Schematic of the Circuitry of the UPR
, 2013 The model depicts the circuitry of the UPR (red) and the S-UPR (blue). Transcriptional control of HAC1 is indicated by an icon representing a rheostat affording gain control of the UPR; Ire1p-dependent HAC1u mRNA splicing is indicated by an icon ...
Peter Walter (4403) +2 more
core +1 more source
Methods for Investigating the UPR in Filamentous Fungi
, 2011 Filamentous fungi have a high-capacity secretory system and are therefore widely exploited for the industrial production of native and heterologous proteins. However, in most cases, the yields of nonfungal proteins are significantly lower than those obtained for fungal proteins.
Guillemette, Thomas +6 more
openaire +4 more sources
Sel1l preserves condylar cartilage matrix homeostasis by regulating PERK signaling
Interdisciplinary Medicine, EarlyView.Our study revealed that the expression of Sel1l was downregulated in OA cartilage and that Sel1l deficiency induced cartilage catabolism. Mechanistically, Sel1l depletion aberrantly activated PERK signaling and resulted in ER stress. PERK inhibition rescued the phenotype of Sel1l‐deficient chondrocytes and alleviated TMJOA pathogenesis.
Xinqi Huang +3 more
wiley +1 more source
Crosstalk between endoplasmic reticulum stress and mitochondrial homeostasis: A new perspective on ophthalmic disease treatment. [PDF]
J Cell Commun SignalThe graphical abstract follows a top‐to‐bottom flow: stressors → ER–mitochondria crosstalk → ophthalmic diseases. The central panel highlights three core mitochondria‐associated membrane function axes, color‐coded as follows: light yellow for Ca2+ homeostasis, light blue for mitochondrial dynamics, and light red for mitophagy.
Jiang L +5 more
europepmc +2 more sources
Interdisciplinary Medicine, EarlyView.Extracellular vesicles play pivotal roles in both healthy hematopoiesis and hematologic malignancies. They not only regulate hematopoietic stem cell fitness but also drive cancer progression and drug resistance. Their clinical potential spans from serving as non‐invasive biomarkers to acting as innovative therapeutic platforms and drug delivery ...
Fengyu Chen +5 more
wiley +1 more source
Two decades of tropical soil analyses for a better understanding of soil organic carbon
Scientific DataSoil organic carbon is essential for soil fertility, water retention and nutrient storage. Although crucial for climate regulation and food security, tropical soils remain insufficiently documented.
Marie Tella +19 more
doaj +1 more source
ER Proliferation under UPR-Inducing Conditions
, 2013 (A) Determination of ER abundance in control and UPR-induced cells. Representative cells are shown. The UPR was induced in wild-type cells by addition of DTT. Ultrastructure of control cells and UPR-induced cells was analyzed using ImageJ.
Kent L McDonald (66699) +2 more
core +1 more source
Journal of Applied Toxicology, EarlyView.ABSTRACT One of the most serious complications associated with the use of the chemotherapeutic agent doxorubicin (DOX) is cardiomyopathy. Although cardioprotective drugs such as angiotensin receptor‐neprilysin inhibitors (ARNI) are used to prevent cardiomyopathy in DOX patients, no studies have reported the relationship between ARNI and endoplasmic ...
Mert Unvan +3 more
wiley +1 more source