Results 101 to 110 of about 101,011 (227)
British Journal of Pharmacology, EarlyView.Abstract Background and Purpose Site‐specific antibody modification is a useful chemical strategy to elaborate antibody therapeutic function. Conventional lysine‐ or cysteine‐based conjugation methods generate heterogeneous products, while protein engineering approaches are resource‐intensive.
Karolina Krygier +2 more
wiley +1 more source
Texts construction: professional functional style tea ching in Physical Culture degree course
Revista MENDIVE, 2015 The texts construction teaching of professional functional stile is considered one of physical culture future graduate necessities since they demand from the mentioned stile mastery to f ulfil one of the corresponding roles in the working entity. However,
Ana Delia Martínez Bravo +2 more
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Status Hematologi Ikan Nila (Oreochromis niloticus) Pada Kolam Budidaya di UPR Sumber Mina Lestari dan UPR Mina Lestari [PDF]
, 2016 Ikan adalah salah satu organisme yang paling banyak hidup di lingkungan perairan dan menjadi ivamperiventerhadap perubahan lingkugan akibat adanya pencemaran.
Wicaksono, RadityaDanan
core
British Journal of Pharmacology, EarlyView.Abstract Venetoclax combined with hypomethylating agents has improved treatment for older or unfit patients with acute myeloid leukaemia (AML), but resistance and relapse remain common. This review analyses the rationale for combining venetoclax with inhibitors of histone deacetylase (HDAC).
Jaebok Lee, Marc Diederich
wiley +1 more source
The UPR reduces glucose metabolism via IRE1 signaling
, 2017 Neurons are highly dependent on glucose. A disturbance in glucose homeostasis therefore poses a severe risk that is counteracted by activation of stress responses to limit damage and restore the energy balance.
Scheper, Wiep; id_orcid +12 more
core +1 more source
Rethinking diabetic retinopathy: Homeostatic mechanisms for retinal clearance
Diabetic Medicine, EarlyView.In the healthy retina, balanced production and clearance of metabolic waste and fluid maintain retinal homeostasis and normal visual function. Diabetes disrupts this balance, increasing the accumulation of metabolic waste products, including advanced glycation end products (AGEs) and advanced lipoxidation end products (ALEs), while impairing waste and ...
Karis Little +7 more
wiley +1 more source
PERBANDINGAN TINGKAT KEUNTUNGAN DAN PEMASARAN UNIT PEMBENIHAN RAKYAT IKAN LELE (Clarias sp.) PADA UPR KELOMPOK DAN UPR SWADAYA DI KOTA PALEMBANG [PDF]
, 2019 Abstrak. Penelitian ini bertujuan (1) untuk Menghitung tingkat keuntungan UPR Kelompok dan UPR Swadaya Benih Ikan Lele di Kota Palembang (2) Menghitung tingkat efisiensi pemasaran Benih Ikan Lele yang dilihat dari saluran pemasaran, marjin pemasaran ...
Septianita, Dian
core
Diabetes, Obesity and Metabolism, EarlyView.ABSTRACT Aims Animal models of prediabetes (Pre‐DM) are essential for studying metabolic disease and testing therapies, yet high‐fat diet (HFD) and HFD‐plus‐streptozotocin (STZ) protocols vary in feeding duration, STZ dose, and diagnostic criteria and rarely account for sex.
Min Xu +7 more
wiley +1 more source
The FEBS Journal, EarlyView.We investigated the potential of iloperidone as an activator of Sigma‐1 receptor (S1R) neuroprotective function in juvenile Huntington's disease (jHD). We tested iloperidone on cortical neurons differentiated from patient‐derived iPSCs, demonstrating that it acts as a S1R agonist, decreasing apoptosis, huntingtin aggregation, and oxidative stress ...
Ersilia Fornetti +11 more
wiley +1 more source
The FEBS Journal, EarlyView.Misfolding mutations in pancreatic lipase have been identified as potential contributors of chronic pancreatitis, an inflammatory disease of the human pancreas. Here, we describe the effect of these misfolding mutations on pancreatic lipase structure using molecular dynamics simulations and structural modeling.
Gyula Hoffka, András Szabó
wiley +1 more source