Results 141 to 150 of about 75,497 (305)
Allergy, EarlyView.Cobalt chloride (CoCl2) and cobalt nanoparticles (CoNPs) induce a shared, severity‐dependent inflammatory response in cobalt‐sensitized skin characterized by activation of interferon signaling, inflammatory pathways (TNF/NF‐κβ, IL6‐STAT3), apoptosis/UPR, cell cycle programs, and glycolysis.
P. Werner +8 more
wiley +1 more source
Regulation of cardiac fibroblast cell death by unfolded protein response signaling
Frontiers in PhysiologyThe endoplasmic reticulum (ER) is a tightly regulated organelle that requires specific environmental properties to efficiently carry out its function as a major site of protein synthesis and folding.
Mary B. Rowland +3 more
doaj +1 more source
A quad‐cistronic fluorescent biosensor system for real‐time detection of subcellular Ca2+ signals
British Journal of Pharmacology, EarlyView.Background and Purpose The calcium ion (Ca2+) is a versatile cellular messenger regulating a variety of biological processes. Compounds modulating subcellular Ca2+ signals hold substantial pharmacological potential. Advances in fluorescent biosensors have revolutionised Ca2+ imaging.
Anna Lischnig +7 more
wiley +1 more source
Dependence of oxidative stress responses on UPR components.
, 2013 (A, B) Importance of core UPR genes for SKN-1-mediated oxidative stress responses. Induction of skn-1 and skn-1 target gene transcription by AS (A) or t-BOOH (B) was impaired by RNAi against core UPR genes or in core UPR factor mutants (indicated by M ...
Kira M. Glover-Cutter (218155) +2 more
core +1 more source
CKAP4 Regulates ERS‐Induced Apoptosis in Osteoclasts Through FOXO3 in Periodontitis
Cell Proliferation, EarlyView.CKAP4 promotes the transcription of PERK via FOXO3 in OCs, thereby facilitating ER stress‐induced apoptosis. In periodontitis, the reduction of CKAP4 in OCs leads to decreased OC apoptosis, which exacerbates alveolar bone resorption. ABSTRACT Periodontitis is a prevalent oral disease characterised by chronic inflammation and irreversible alveolar bone ...
Jiayu Cheng +12 more
wiley +1 more source
The proffesional superation concerning Computer sciences in University teachers
Revista MENDIVE, 2015 The upgrade studies of the university professors is considered one of the greatest challenges of the higher educatio n at present. The university professors should be capable to achieve a competent professional performance using informatics and ...
Rayko Manuel Molinet Herrera +2 more
doaj
Cell Proliferation, EarlyView.AREG coordinates cell proliferation and lipid metabolism reprogramming during liver regeneration and targeting lipid metabolism can promote liver regeneration. ABSTRACT Hepatocyte proliferation restores liver mass after partial hepatectomy (PHx), but the metabolic cost of this process remains unclear.
Yuelei Hu +7 more
wiley +1 more source
reservedThis thesis examines the Universal Periodic Review (UPR) as a tool of UN multilateral diplomacy, assessing its role in shaping state practice and opinio juris and contributing to the progressive development of customary international law in human
SURIAN, ALESSIA
core
The FEBS Journal, EarlyView.Proteostasis ensures proper protein folding, modification, and degradation, while its impairment triggers ER stress. Chronic ER stress and maladaptive UPR via the CHOP–ERO1 axis remodel ERMCs, altering calcium signaling and mitochondrial metabolism.
Giorgia Maria Renna +5 more
wiley +1 more source
UPR-Mediated Membrane Biogenesis in B Cells
, 2020 The unfolded protein response (UPR) can coordinate the regulation of gene transcription and protein translation to balance the load of client proteins with the protein folding and degradative capacities of the ER.
Joseph W Brewer, Suzanne Jackowski
core