Results 161 to 170 of about 111,661 (295)

The Role of Oxidative Stress in Periodontitis

Journal of Periodontal Research, EarlyView.
Oxidative stress is involved in multiple chemical reactions that take place in different intracellular organelles: mitochondria, rough endoplasmic reticulum, peroxisomes, autophagy, and aging, and can be influenced by exogenous factors: nutrition, physical activity, psychological status, environmental conditions, microbiome, and drugs.
Pedro Bullon, Francesca Giampieri, Beatriz Bullon, Maurizio Battino   +3 more
wiley   +1 more source

Napping during cognitive behavioural therapy for insomnia: Friends or foes?

Journal of Sleep Research, Volume 34, Issue 2, April 2025.
Summary Cognitive and Behavioural Therapy for Insomnia (CBT‐I) is the gold standard treatment for chronic insomnia, with one crucial step being the restriction of time spent in bed. This restriction often intensifies early afternoon sleepiness, leading to a natural gateway for a short recuperative nap, which might foster adherence to CBT‐I over time ...
Brice Faraut, Louise Gaillard, Annabelle Labonne, Julie Margrethe Dubois, Joëlle Adrien, Damien Léger   +5 more
wiley   +1 more source

Investigation of the “Not Better Explained” Diagnosis Criteria in Sleep Disorder Classifications: A Systematic Content Analysis and Critical Review

Journal of Sleep Research, EarlyView.
The “Not Better Explained” (NBE) criterion plays a key role in preventing diagnostic misclassification by structuring causal reasoning in sleep medicine. This systematic content analysis compares the use, wording, and excluded conditions of NBE criteria across the ICSD‐3‐TR and DSM‐5‐TR for ten major sleep disorders.
Jean‐Arthur Micoulaud‐Franchi, Vincent P. Martin, Julien Coelho, Régis Lopez, Pierre‐Alexis Geoffroy, Laure Peter‐Derex, Isabelle Lambert, Charles M. Morin, Clélia Quiles, Christophe Gauld   +9 more
wiley   +1 more source

Metformin alleviates aging-associated periodontitis via NRF2-mediated restoration of the IRE1α dependent unfolded protein response. [PDF]

Bioact Mater
Sun Y, Chen Q, Zhao Y, Yin Y, Chen Q, Yang L, Liu Z, Chen R, Xu X, Song J.   +9 more
europepmc   +1 more source

Genetic Interactions Due to Constitutive and Inducible Gene Regulation Mediated by the Unfolded Protein Response in C. elegans.

PLoS Genetics, 2005
The unfolded protein response (UPR) is an adaptive signaling pathway utilized to sense and alleviate the stress of protein folding in the endoplasmic reticulum (ER). In mammals, the UPR is mediated through three proximal sensors PERK/PEK, IRE1, and ATF6.
doaj   +1 more source

Endoplasmic reticulum stress in disease pathogenesis: its implications for therapy. [PDF]

Signal Transduct Target Ther
Wei S, Zhang N, Zhang H, Chen Z, Li S, Wu W, Liu Z, Xia Z, Luo P, Cheng Q.   +9 more
europepmc   +1 more source

Gallic Acid‐Responsive microRNAs Reprogram Lignification During Drought Acclimation Process in Spearmint

Plant Biotechnology Journal, EarlyView.
ABSTRACT Mentha spicata L. (spearmint) is a high‐value aromatic and medicinal species, whose productivity is strongly affected by water deficit. Nevertheless, the molecular mechanisms underlying drought acclimation in this mint remain largely unexplored. Thus, here, we investigated the microRNA‐mediated regulatory processes triggered in M.
Alessia D'Agostino, Gabriele Di Marco, Gerardo Pepe, Adelaide Teofani, Chiara Pontecorvi, Manuela Helmer‐Citterich, Antonella Canini, Angelo Gismondi   +7 more
wiley   +1 more source

Brucella Omp25 activates the unfolded protein response to promote intracellular proliferation and inflammation. [PDF]

J Biol Chem
Yang JK, Huang S, Hou YP, Yuan HF, Wang Y, Li M, Cao LB, Xia T, Shu HB, Wu X.   +9 more
europepmc   +1 more source

A Bioluminescent Reporter System for Real‐Time Monitoring of the Unfolded Protein Response in Plants

Plant Biotechnology Journal, EarlyView.
ABSTRACT The unfolded protein response (UPR) is a critical mechanism for maintaining endoplasmic reticulum (ER) homeostasis under stress. Here, we developed a bioluminescent reporter system, AtbZIP60‐LUC, in Arabidopsis to dynamically monitor ER stress by coupling IRE1‐mediated splicing of bZIP60 mRNA to firefly luciferase (LUC) expression.
Yao Liu, Yue Niu, Yunxi Zhao, Wenwen Zhang, Yonglun Lv, Minqing Liu, Qian Zhang, Jiaojiao Wang, Xin Zhang, Yanjie Li, Hui Zhang, Yingying Zhang, Yan Bao   +12 more
wiley   +1 more source

PRAS40 activates the IRE1α-XBP-1-mediated unfolded protein response to exacerbate colorectal cancer by enhancing ST6Gal1-dependent α-2, 6 sialylation of GRP78. [PDF]

Neoplasia
Teng H, Guo Y, Chen X, Fan A, Zhang C, Zhang T, Luo Y, Huang L.   +7 more
europepmc   +1 more source