Results 151 to 160 of about 111,661 (295)
The FEBS Journal, EarlyView.Proteostasis ensures proper protein folding, modification, and degradation, while its impairment triggers ER stress. Chronic ER stress and maladaptive UPR via the CHOP–ERO1 axis remodel ERMCs, altering calcium signaling and mitochondrial metabolism.
Giorgia Maria Renna +5 more
wiley +1 more source
Proteostasis of organelles in aging and disease
The FEBS Journal, EarlyView.Cells rely on regulated proteostasis mechanisms to keep their internal compartments functioning properly. When these mechanisms fail, damaged proteins accumulate, disrupting organelles, such as the nucleus, mitochondria, endoplasmic reticulum, Golgi, and lysosomes, as well as membraneless organelles, such as stress granules, processing bodies, the ...
Yara Nabawi +5 more
wiley +1 more source
Biogenesis of TNF‐α‐insights into proteostasis and inflammation
The FEBS Journal, EarlyView.TNF‐α biogenesis, trafficking, and signalling are tightly and reciprocally coupled to cellular proteostasis systems, including ER chaperones and endoplasmic reticulum‐associated degradation. This bidirectional crosstalk determines whether TNF‐α responses are adaptive or proteotoxic.
Bailasan Haidar +3 more
wiley +1 more source
The FEBS Journal, EarlyView.We investigated the potential of iloperidone as an activator of Sigma‐1 receptor (S1R) neuroprotective function in juvenile Huntington's disease (jHD). We tested iloperidone on cortical neurons differentiated from patient‐derived iPSCs, demonstrating that it acts as a S1R agonist, decreasing apoptosis, huntingtin aggregation, and oxidative stress ...
Ersilia Fornetti +11 more
wiley +1 more source
IRE1 signaling increases PERK expression during chronic ER stress
Cell Death and DiseaseThe Unfolded Protein Response (UPR) is an essential cellular process activated by the accumulation of unfolded proteins within the Endoplasmic Reticulum (ER), a condition referred to as ER stress.
Gideon Ong +5 more
doaj +1 more source
International Journal of Cosmetic Science, EarlyView.Development of a biomimetic calcium‐based minimalist skin formulation using Design of Experiment (DoE) to correlate key ingredients' effect on the sensory and physico‐chemical properties of the emulsion. Abstract Objectives Innovation is considered a determining factor in the highly competitive environment of the cosmetic industry to introduce products
Marc Lavarde +7 more
wiley +1 more source
International Journal of Cosmetic Science, EarlyView.By formulating creams with caprylic acid‐based hydrophobic Natural Eutectic Solvents and assessing their stability, rheological behaviour and sensory properties, this study demonstrates how these systems can act as multifunctional, COSMOS‐compliant ingredients that modulate emulsion characteristics without compromising formulation properties.
Alexis Verger +7 more
wiley +1 more source
International Journal of Cosmetic Science, EarlyView.Hydrophobic natural eutectic solvents can function as structural oil phase substitutes in creams prepared by low‐energy processes, enabling sustainable, regulation‐compliant formulations with desirable sensory profiles. Abstract Objective This work evaluates whether hydrophobic natural eutectic solvents can replace the conventional oil phase in ...
A. Verger +8 more
wiley +1 more source
SIB1‐SEC23A undergo ER to chloroplast relocalization to mediate immunity in Arabidopsis thaliana
Journal of Integrative Plant Biology, EarlyView.SEC23A mediates membrane trafficking between the endoplasmic reticulum (ER) and Golgi apparatus and interacts with the immunity protein SIGMA FACTOR‐BINDING PROTEIN1 in Arabidopsis. Under stress, both proteins relocate from the ER to chloroplasts, suppressing photosynthesis genes and enhancing defense genes.
Jialin Peng +7 more
wiley +1 more source