Results 151 to 160 of about 101,011 (227)

Single‐Cell Mapping Identifies Aging‐Associated Neutrophil Remodeling Across Multiple Organs

Aging Cell, Volume 25, Issue 10, October 2026.
Single‐cell transcriptomic profiling across multiple organs identifies aging reshapes neutrophil differentiation from the bone marrow to peripheral tissues. Computation analysis identifies an age‐enriched Neu06‐IL6 neutrophil state and predicts IL‐6 as one of a candidate regulator for neutrophil remodeling.
Yuman Wang, Teding Chang, Yangguang Fu, Guangyu Liang, Huicheng Liu, Le Zhang, Jinhua Yan, Man Liu, Anding Liu, Cuntai Zhang   +9 more
wiley   +1 more source

Dual regulation of the unfolded protein response by IGF2BP3 during ER stress. [PDF]

Genes Dev
Anisimova AS, Omerbegovic S, Mihailovic M, Gratzl S, Hornegger H, Fischer I, Versteeg GA, Ameres SL, Karagöz GE.   +8 more
europepmc   +1 more source

Targeting Ero1L by Parthenolide Alleviates Cellular Senescence and Fibrosis of Localized Scleroderma by Regulating Mitochondria‐Associated Endoplasmic Reticulum Membranes Stabilization

Aging Cell, Volume 25, Issue 10, October 2026.
PTL inhibits cell senescence and alleviates fibrosis of Los by regulating Ero1L‐mediated mitochondria‐associated endoplasmic reticulum membranes stabilization. ABSTRACT Mitochondrial dysfunction drives scleroderma pathogenesis. The mitochondria‐associated endoplasmic reticulum membrane (MAM) regulates mitochondrial function.
Fei Wang, Ru Xing, Meijuan Xie, Yimin Qin, Yunchao Zhang, Dan Cao, Gu He, Xiaoyan Lyu   +7 more
wiley   +1 more source

Activation of Thiamine Pyrophosphokinase TPK-1 Contributes to 6-PPD Quinone-Induced Immunosuppression by Inhibiting Mitochondrial UPR in <i>Caenorhabditis elegans</i>. [PDF]

Toxics
Wu Z, Hu G, Li Y, Wang D.
europepmc   +1 more source

NTAQ1 Promotes Hepatocellular Carcinoma Growth by Facilitating the Protein Degradation of the Tumor Suppressor PRDM2

Cancer Science, Volume 117, Issue 10, Page 2803-2818, October 2026.
Copy number variation analysis in The Cancer Genome Atlas identified NTAQ1 as a potential driver of HCC progression. NTAQ1 accelerates tumor growth by promoting the degradation of the tumor suppressor protein PRDM2, thereby impairing DNA repair and suppressing apoptosis. These findings indicate that NTAQ1 could be a valuable target for the treatment of
Tomohiko Ikehara, Hajime Otsu, Taro Tobo, Kiyotaka Hosoda, Tadashi Abe, Masahiro Hashimoto, Yusuke Nakano, Katsushi Dairaku, Yuya Ono, Yuki Miyata, Chihiro Matsumoto, Takanari Tatsumi, Satoshi Higuchi, Takashi Ofuchi, Akinori Tsujimoto, Yuki Ando, Qingjiang Hu, Yusuke Yonemura, Akira Shimizu, Takaaki Masuda, Yuji Soejima, Koshi Mimori   +21 more
wiley   +1 more source

Targeting the unfolded protein response in cancer: mechanisms, small-molecule inhibitors, and translational challenges. [PDF]

Front Immunol
Lin M, Li Z.
europepmc   +1 more source

Evaluating the suitability of six hydrophobic natural eutectic solvents as the internal phase in a cosmetic cream formulation

International Journal of Cosmetic Science, Volume 48, Issue 5, Page 1029-1041, October 2026.
Hydrophobic natural eutectic solvents can function as structural oil phase substitutes in creams prepared by low‐energy processes, enabling sustainable, regulation‐compliant formulations with desirable sensory profiles. Abstract Objective This work evaluates whether hydrophobic natural eutectic solvents can replace the conventional oil phase in ...
A. Verger, R. Grard, E. Vrignaud, X. Perse, S. Bouderbala, L. Boudesocque‐Delaye, M. Grisel, E. Gore, E. Munnier   +8 more
wiley   +1 more source

BCAM-AKT2 fusion protein promotes unfolded protein response driven oncogenic signaling in SKOV3 epithelial ovarian cancer cell line. [PDF]

PLoS One
Khazem H, Zemler RS, David LV, Reder D, Sharon SM, Hantisteanu S, Werner H, Bruchim I.   +7 more
europepmc   +1 more source

Building an Interleukin‐10‐Producing Identity: How B Cells Acquire Interleukin‐10 Competence and How Plasma Cell Differentiation Consolidates This Program

Immunological Reviews, Volume 343, Issue 1, October 2026.
ABSTRACT Interleukin (IL)‐10‐producing B cells represent an archetype for the regulatory functions of B cells. Here, we review the cell‐surface receptors and transcriptional regulators that control IL‐10 expression in B cells and enable their regulatory function in vivo.
Bui Thi Cuc, Yanli Tong, Zhiguo Wu, Daniel Alvarez‐Simon, Simon Fillatreau   +4 more
wiley   +1 more source

Cellular Responses to Flavivirus Infections: Stress Signaling at the Crossroads of Host Defense and Virus Infection. [PDF]

Viruses
Badu P, González ETC, Pager CT.
europepmc   +1 more source