Results 1 to 10 of about 19,138 (225)

Structural and functional basis for RNA cleavage by Ire1 [PDF]

BMC Biology, 2011
Background The unfolded protein response (UPR) controls the protein folding capacity of the endoplasmic reticulum (ER). Central to this signaling pathway is the ER-resident bifunctional transmembrane kinase/endoribonuclease Ire1.
Stroud Robert M, Finer-Moore Janet, Egea Pascal F, Korostelev Andrei A, Korennykh Alexei V, Zhang Chao, Shokat Kevan M, Walter Peter   +7 more
doaj   +12 more sources

Pharmacological Targeting of IRE1 in Cancer [PDF]

Trends in Cancer, 2020
IRE1α (inositol requiring enzyme 1 alpha) is one of the main transducers of the unfolded protein response (UPR). IRE1α plays instrumental protumoral roles in several cancers, and high IRE1α activity has been associated with poorer prognoses. In this context, IRE1α has been identified as a potentially relevant therapeutic target.
Leif A Eriksson, Eric Chevet, Xavier Guillory   +2 more
exaly   +5 more sources

Signal sequence-triage is activated by translocon obstruction sensed by an ER stress sensor IRE1α

Cell Structure and Function, 2023
Secretory pathway proteins are cotranslationally translocated into the endoplasmic reticulum (ER) of metazoan cells through the protein channel, translocon.
Ashuei Sogawa, Ryota Komori, Kota Yanagitani, Miku Ohfurudono, Akio Tsuru, Koji Kadoi, Yukio Kimata, Hiderou Yoshida, Kenji Kohno   +8 more
doaj   +1 more source

Mechanism of Hsp70 specialized interactions in protein translocation and the unfolded protein response [PDF]

Open Biology, 2020
Hsp70 chaperones interact with substrate proteins in a coordinated fashion that is regulated by nucleotides and enhanced by assisting cochaperones.
Natacha Larburu, Christopher J. Adams, Chao-Sheng Chen, Piotr R. Nowak, Maruf M. U. Ali   +4 more
doaj   +1 more source

Icariin inhibits the expression of IL-1β, IL-6 and TNF-α induced by OGD/R through the IRE1/XBP1s pathway in microglia

Pharmaceutical Biology, 2021
Context Icariin (ICA), a flavonol glycoside extracted from Epimedium brevicornum Maxim (Berberidaceae), has been proven to inhibit inflammatory response in ischaemic rats in our laboratory's previous work.
Zhen-Tao Mo, Jie Zheng, Yu-ling Liao
doaj   +1 more source

Classical swine fever virus employs the PERK- and IRE1-dependent autophagy for viral replication in cultured cells.

Virulence, 2021
Endoplasmic reticulum stress (ERS)-mediated autophagy is indispensable for modulation of replication and pathogenesis of numerous mammalian viruses. We have previously shown that classical swine fever virus (CSFV) infection induces ERS-mediated autophagy
Erpeng Zhu, Huawei Wu, Wenxian Chen, Yuwei Qin, Jiameng Liu, Shuangqi Fan, Shengming Ma, Keke Wu, Qian Mao, Chaowei Luo, Yixian Qin, Lin Yi, Hongxing Ding, Mingqiu Zhao, Jinding Chen   +14 more
doaj   +1 more source

Quaternary structure analysis of IRE1

microPublication biology, 2023
IRE1 belongs to a type I transmembrane protein family harboring two functional domains, cytoplasmic domain with kinase and RNAse catalytic activity, and the luminal domain, which is involved in the sensing of unfolded proteins. IRE1 molecule undergoes dimerization in the lumenal domain, which functionally activates the catalytic C-terminal domain. IRE1
Bashir, Samirul, Pal, Debnath, Qadri, Ozaira, Banday, Mariam, Fazili, Khalid   +4 more
openaire   +2 more sources

Fat body Ire1 regulates lipid homeostasis through the Xbp1s-FoxO axis in Drosophila

iScience, 2021
Summary: The endoplasmic reticulum (ER)-resident transmembrane protein kinase/RNase Ire1 is a conserved sensor of the cellular unfolded protein response and has been implicated in lipid homeostasis, including lipid synthesis and transport, across species.
Peng Zhao, Ping Huang, Tongfu Xu, Xiaoxiang Xiang, Ying Sun, Jingqi Liu, Cheng Yan, Lei Wang, Jiamei Gao, Shang Cui, Xiangdong Wang, Lixing Zhan, Haiyun Song, Jingnan Liu, Wei Song, Yong Liu   +15 more
doaj   +1 more source

The ADP-binding kinase region of Ire1 directly contributes to its responsiveness to endoplasmic reticulum stress

Scientific Reports, 2021
Upon endoplasmic-reticulum (ER) stress, the ER-located transmembrane protein, Ire1, is autophosphorylated and acts as an endoribonuclease to trigger the unfolded protein response (UPR).
Quynh Giang Le, Yuki Ishiwata-Kimata, Thi Huong Phuong, Shigeto Fukunaka, Kenji Kohno, Yukio Kimata   +5 more
doaj   +1 more source

Endoplasmic reticulum stress activates human IRE1α through reversible assembly of inactive dimers into small oligomers

eLife, 2022
Protein folding homeostasis in the endoplasmic reticulum (ER) is regulated by a signaling network, termed the unfolded protein response (UPR). Inositol-requiring enzyme 1 (IRE1) is an ER membrane-resident kinase/RNase that mediates signal transmission in
Vladislav Belyy, Iratxe Zuazo-Gaztelu, Andrew Alamban, Avi Ashkenazi, Peter Walter   +4 more
doaj   +1 more source