Results 31 to 40 of about 19,138 (225)
Physiological roles of regulated Ire1 dependent decay [PDF]
Frontiers in Genetics, 2014 Inositol-requiring enzyme 1 (Ire1) is an important transducer of the unfolded protein response (UPR) that is activated by the accumulation of misfolded proteins in the endoplamic reticulum (ER stress). Activated Ire1 mediates the splicing of an intron from the mRNA of Xbp1, causing a frame-shift during translation and introducing a new carboxyl domain ...
Dina S. Coelho, Pedro M. Domingos
openaire +3 more sources
OVEREXPRESSION OF DOMINANT-NEGATIVE IRE1 ENZYME IN H1299-shE6AP CELLS INCREASES HEAT SHOCK ELEMENT-DEPENDENT TRANSCRIPTION [PDF]
Biotechnologia Acta, 2015 To investigate IRE1-dependent branch of endoplasmic reticulum stress pathway in various cancer cells we created cDNA-constructs for expression of dominant-negative inositol-requiring enzyme – 1 IRE1 and cytosolic domain of IRE1 fused on a C-terminus with
D. O. , О. H.
doaj +1 more source
The Unraveling Truth About IRE1 and MicroRNAs in Diabetes [PDF]
Diabetes, 2016 Wound healing is a well-regulated complex process that occurs as a cellular response to injury and consists of four phases: hemostasis, inflammation, proliferation, and remodeling (1). Many factors, such as diabetes and obesity, interfere with these stages and lead to wound healing defect.
Souad, Belmadani, Khalid, Matrougui
openaire +2 more sources
IRE1α Promotes Zika Virus Infection via XBP1
Viruses, 2020 Zika virus (ZIKV) is an emergent member of the Flaviviridae family which causes severe congenital defects and other major sequelae, but the cellular processes that support ZIKV replication are incompletely understood.
Elena P. Kolpikova +5 more
doaj +1 more source
Diverse Sphingolipid Species Harbor Different Effects on Ire1 Clustering [PDF]
, 2022 Endoplasmic reticulum (ER) function is dedicated to multiple essential processes in eukaryotes, including the processing of secretory proteins and the biogenesis of most membrane lipids.
Robert F. L. Steuart (23534725) +5 more
core +2 more sources
Inhibition of IRE1 modifies effect of glucose deprivation on the expression of TNFα-related genes in U87 glioma cells [PDF]
The Ukrainian Biochemical Journal, 2015 Inhibition of IRE1 (inositol requiring enzyme-1), the major signaling pathway of endoplasmic reticulum stress, significantly decreases glioma cell proliferation and tumor growth.
I. V. Kryvdiuk +5 more
doaj +1 more source
Engineering ER-stress dependent non-conventional mRNA splicing
eLife, 2018 The endoplasmic reticulum (ER) protein folding capacity is balanced with the protein folding burden to prevent accumulation of un- or misfolded proteins.
Weihan Li +6 more
doaj +1 more source
PLoS Biology, 2010 The unfolded protein response (UPR) is an intracellular signaling pathway that counteracts variable stresses that impair protein folding in the endoplasmic reticulum (ER). As such, the UPR is thought to be a homeostat that finely tunes ER protein folding
David Pincus +6 more
doaj +1 more source
Inhibition of IRE1 results in decreased scar formation [PDF]
Wound Repair and Regeneration, 2017 AbstractWound healing is characterized by the production of large amounts of protein necessary to replace lost cellular mass and extracellular matrix. The unfolded protein response (UPR) is an important adaptive cellular response to increased protein synthesis.
Tatiana V. Boyko +8 more
openaire +2 more sources
Chaperone BiP controls ER stress sensor Ire1 through interactions with its oligomers
Life Science AllianceActivation of the stress sensor Ire1 is triggered by stress-induced conformational changes in its luminal domains that promote Ire1 oligomerization.
Sam Dawes +10 more
doaj +1 more source