Results 51 to 60 of about 19,138 (225)

Pumilio protects Xbp1 mRNA from regulated Ire1-dependent decay

Nature Communications, 2022
In Drosophila, ER-targeted mRNAs are degraded by Ire1-dependent pathway. Here the authors report that the fly mRNA binding protein Pumilio is phosphorylated by Ire1 and binds to Xbp1 mRNA, protecting it from the non-canonical endoribonuclease activity of
Fátima Cairrão, Cristiana C. Santos, Adrien Le Thomas, Scot Marsters, Avi Ashkenazi, Pedro M. Domingos   +5 more
doaj   +1 more source

MCMV M50 interacts with IRE1.

, 2013
(A) NIH-3T3 cells stably expressing TEV-HA-tagged IRE1 were mock infected or infected with MCMV at an MOI of 5. Whole cell lysates (WCL) were applied to an anti-HA sepharose matrix.
Julia M. Burkhart (443213), René P. Zahedi (443215), Matthias Budt (382049), Wolfram Brune (185524), Sebastian Stahl (443212), Hermine Mohr (160119), Florian Hinte (443214), Boaz Tirosh (204714), Zsolt Ruzsics (75383), Albert Sickmann (5325)   +9 more
core   +1 more source

Human cDC1s display constitutive activation of the UPR sensor IRE1 [PDF]

, 2022
The intracellular mechanisms safeguarding DC function are of biomedical interest in several immune‐related diseases. Type 1 conventional DCs (cDC1s) are prominent targets of immunotherapy typified by constitutive activation of the unfolded protein ...
Osorio, Fabiola, Gutiérrez, Diane, Mauro Parra‐Cordero, Dominique Fernández, Osorio Olivares, Fabiola, Fabiola Osorio, Gutiérrez Cabrera, Diane, García González, Paulina, García‐González, Paulina, Parra‐Cordero, Mauro, Paulina García‐González, Fernández, Dominique, Parra Cordero, Mauro, Diane Gutiérrez   +13 more
core   +1 more source

Peptidomimetic-based identification of FDA approved compounds inhibiting IRE1 activity [PDF]

, 2020
International audienceInositol Requiring Enzyme 1 (IRE1) is a bifunctional serine/threonine kinase and endoribonuclease that is a major mediator of the Unfolded Protein Response (UPR) during endoplasmic reticulum (ER) stress.
Doultsinos, Dimitrios, James C. Paton, Samali, A., Paton, A. W., Paton, J. C., Afshin Samali, Paton, James C, Paton, Adrienne W, Carlesso, Antonio, Antonio Carlesso, Samali, Afshin, Chevet, Eric, Dimitrios Doultsinos, Adrienne W. Paton, Doultsinos, D., Chevet, E., Chintha, Chetan, Eriksson, Leif A, Eriksson, Leif A,, Chetan Chintha, Leif A. Eriksson, Carlesso, Antonio,, Chintha, C., Eric Chevet   +23 more
core   +1 more source

Aberrant GRP78 Phase Transition Sustains Endothelial IRE1α Signaling and Drives Blood–Brain Barrier Failure in Cerebral Amyloid Angiopathy

Advanced Science, EarlyView.
Vascular Aβ40 corrupts GRP78 phase behavior in brain endothelial cells, sustaining IRE1α–TRAF2–JNK signaling and driving apoptosis, tight junction loss, and blood–brain barrier failure in cerebral amyloid angiopathy. Pharmacological IRE1α inhibition restores vascular integrity, reduces leakage, and improves functional outcomes, revealing a targetable ...
Honglin Zheng, Qiang Li, Haiyang Luo, Yapei Yuan, Na Zhang, Yongting Lu, Suying Duan, Jieshi Zhong, Hang Zhang, Chenyang Liu, Yaochong Zhang, Wenzhuo Zhao, Yaxuan Song, Tuo Wang, Si Yan, Yapeng Li, Han Liu, Yuan Gao, Zongping Xia, Yuming Xu   +19 more
wiley   +1 more source

A Novel Pak1 Activator Ameliorates ER Stress for HFpEF Therapy

Advanced Science, EarlyView.
Chronic metabolic stress is a major contributor to HFpEF progression. Under prolonged metabolic stress, Pak1 activity becomes impaired, contributing to disrupted ER proteostasis, cardiomyocyte apoptosis, fibrosis, and diastolic dysfunction. Mechanistically, Pak1 overexpression activates the ERK1/2–MNK1–eIF4E signaling axis, promotes translational ...
Honglin Xu, Hongyuan Zhang, Tayyiba Azam, Susanne S. Hille, Yingjuan Liu, Min Zi, Jiaqing Lang, He Yu, Yujia Cao, Bernard D. Keavney, Tamer M. A. Mohamed, Jessica M. Miller, Riham R. E. Abouleisa, Ming Xu, Elizabeth J. Cartwright, Oliver J. Müller, Ming Lei, Xin Wang   +17 more
wiley   +1 more source

M50 expression reduces IRE1 protein levels.

, 2013
(A) NIH-3T3 cells were cotransfected with plasmids encoding IRE1-HA (1 µg) and Flag-tagged M50 or m144 (0.5, 1, or 2 µg). After 24 h, cell lysates were analyzed by immunoblot using protein- or tag-specific antibodies. (B) NIH-3T3 cells were cotransfected
Julia M. Burkhart (443213), René P. Zahedi (443215), Matthias Budt (382049), Wolfram Brune (185524), Sebastian Stahl (443212), Hermine Mohr (160119), Florian Hinte (443214), Boaz Tirosh (204714), Zsolt Ruzsics (75383), Albert Sickmann (5325)   +9 more
core   +1 more source

Marburg virus regulates the IRE1/XBP1-dependent unfolded protein response to ensure efficient viral replication

Emerging Microbes and Infections, 2019
Viruses regulate cellular signalling pathways to ensure optimal viral replication. During Marburg virus (MARV) infection, large quantities of the viral glycoprotein GP are produced in the ER; this may result in the activation of the unfolded protein ...
Cornelius Rohde, Stephan Becker, Verena Krähling   +2 more
doaj   +1 more source

The Cancer Cell Metabolic Reprogramming Remodels the Tumor Microenvironment: Molecular Mechanisms and Therapeutic Strategies

Advanced Science, EarlyView.
This review elucidates how cancer cell metabolic reprogramming—across glucose, lipid, amino acid, and nucleotide pathways—remodels the tumor microenvironment to suppress anti‐tumor immunity and promote immune escape. Targeting these metabolic axes offers promising strategies to overcome immunotherapy resistance and enhance cancer treatment.
Guoqing Xiang, Zhicheng Zhou, Xue Jiang, Zhenguang Du, Yangyang Zhan, Xinli Liu   +5 more
wiley   +1 more source

The molecular basis for selective inhibition of unconventional mRNA splicing by an IRE1-binding small molecule

, 2012
Free to read at publisher's site.\ud \ud IRE1 couples endoplasmic reticulum unfolded protein load to RNA cleavage events that culminate in the sequence-specific splicing of the Xbp1 mRNA and in the regulated degradation of diverse membrane-bound mRNAs ...
Ron, David, Sadowski, Pawel G., Silverman, Robert H., Goodman, JM, Ron, D, Cross, BCS, Baxendale, Ian R., Zak, Jaroslav, Harding, HP, Jha, Babal Kant, Zak, J, Bond, Peter J., Jha, BK, Goodman, Jonathan M., Neubert, TA, Silverman, RH, Neubert, Thomas A., Baxendale, IR, Sadowski, PG, Cross, Benedict C. S., Bond, PJ, Harding, Heather P.   +21 more
core   +1 more source