Results 41 to 50 of about 19,138 (225)

In vitro RNA Cleavage Assays to Characterize IRE1-dependent RNA Decay

Bio-Protocol, 2019
The kinase/RNase IRE1 is a key effector of the cellular response to endoplasmic reticulum stress. The RNase activity of IRE1 can be measured in cells or in the test tube.
G. Karagöz, Jirka Peschek, Peter Walter, Diego Acosta-Alvear   +3 more
doaj   +1 more source

IRE1 pathway activation in heart.

, 2014
The protein levels of p-IRE1, IRE1, XBP-1 (s).
Hanpeng Huang (549638), Shijiang Zhang (549639), Xilong Zhang (514791), Ning Ding (456674), Wenxiao Ding (549637), Xiaofeng Zhang (172446), Sean Z. Hutchinson (549640)   +6 more
core   +1 more source

IRE1-MEDIATED IMMUNOMODULATION IN GLIOBLASTOMA [PDF]

Neuro-Oncology, 2016
Conference: 12th Meeting of the European-Association-of-Neuro-Oncology Location: GERMANY Date: OCT 12-16, 2016 - Meeting Abstract: OS1 ...
Lhomond, S., Avril, T., Dejeans, N., Pineau, R., Loiseau, H., Maurel, M., Samali, A., Pluquet, O., Chatziioannou, A., Chevet, E.   +9 more
openaire   +2 more sources

Enteroviruses Manipulate the Unfolded Protein Response through Multifaceted Deregulation of the Ire1-Xbp1 Pathway

Viruses, 2022
Many viruses are known to trigger endoplasmic reticulum (ER) stress in host cells, which in turn can develop a protective unfolded protein response (UPR). Depending on the conditions, the UPR may lead to either cell survival or programmed cell death. One
Anna Shishova, Ilya Dyugay, Ksenia Fominykh, Victoria Baryshnikova, Alena Dereventsova, Yuriy Turchenko, Anna A. Slavokhotova, Yury Ivin, Sergey E. Dmitriev, Anatoly Gmyl   +9 more
doaj   +1 more source

How Ire1 senses stress [PDF]

The Journal of Cell Biology, 2007
When demands on the protein folding machinery get too great, how does the cell know? Using a series of yeast mutants, [Kimata et al.][1] now suggest that oligomerization allows an ER stress sensor protein to recognize unfolded protein and signal distress.
openaire   +1 more source

Possible Involvement of X-Box Binding Protein-1 in the Onset of Pulpitis

European Endodontic Journal
Objective: Endoplasmic reticulum (ER) stress plays important roles not only in stress avoidance, but also in cell differentiation and maturation, cell proliferation, and promotion of bone formation.
Tomoya Naruse, Katsuhiro Takeda, Kazuma Yoshida, Shinya Sasaki, Tomoki Kumagai, Yohei Takahashi, Reina Kawai, Jun Nakanishi, Hideki Shiba   +8 more
doaj   +1 more source

Specificity in endoplasmic reticulum-stress signaling in yeast entails a step-wise engagement of HAC1 mRNA to clusters of the stress sensor Ire1

eLife, 2014
Insufficient protein-folding capacity in the endoplasmic reticulum (ER) induces the unfolded protein response (UPR). In the ER lumen, accumulation of unfolded proteins activates the transmembrane ER-stress sensor Ire1 and drives its oligomerization.
Eelco van Anken, David Pincus, Scott Coyle, Tomás Aragón, Christof Osman, Federica Lari, Silvia Gómez Puerta, Alexei V Korennykh, Peter Walter   +8 more
doaj   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Effects of Ire1 gene on virulence and pathogenicity of Candida albicans

Open Life Sciences
With the extensive utilization of antifungal drugs, the drug resistance of Candida albicans is progressively intensifying, and the effect of empirical treatment for C. albicans infection is not evident.
Zhao Huihai, Qin Lixia, Li Mengyan, Jiang Mengyu, Cui Mengge, Wang Hua, Hou Baohua, Wang Fukun, Jia Keran   +8 more
doaj   +1 more source

QRICH1 Disrupts Endoplasmic Reticulum Homeostasis and Amplifies NF‐κB Signaling in Periodontal Ligament Stem Cells to Exacerbate Diabetic Periodontitis

Advanced Science, EarlyView.
QRICH1 has been established as a key factor contributing to impaired osteogenic potential and accelerated apoptosis of PDLSCs in diabetic periodontitis. QRICH1 not only significantly enhances UPR‐associated apoptotic signaling but also amplifies NF‐κB‐mediated inflammatory responses. Its inhibition restores osteogenic capacity and reduces alveolar bone
Han Li, Xiaoyu Yang, He Wang, Yunchun Kuang, Yiyao Hu, Houxuan Li, Shuhong Li, Deping Zeng, Jie Li, Jinlin Song   +9 more
wiley   +1 more source