Results 21 to 30 of about 15,652 (205)
Decoding non-canonical mRNA decay by the endoplasmic-reticulum stress sensor IRE1α
Nature Communications, 2021 IRE1 helps mitigate endoplasmic-reticulum stress by cleaving specific mRNAs at a conserved sequence endomotif via regulated IRE1-dependent decay (RIDD). Here the authors discover a more promiscuous IRE1 activity dubbed RIDD lacking endomotif (RIDDLE).
Adrien Le Thomas +16 more
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IRE1α Promotes Zika Virus Infection via XBP1
Viruses, 2020 Zika virus (ZIKV) is an emergent member of the Flaviviridae family which causes severe congenital defects and other major sequelae, but the cellular processes that support ZIKV replication are incompletely understood.
Elena P. Kolpikova +5 more
doaj +1 more source
Inhibition of IRE1 results in decreased scar formation [PDF]
Wound Repair and Regeneration, 2017 AbstractWound healing is characterized by the production of large amounts of protein necessary to replace lost cellular mass and extracellular matrix. The unfolded protein response (UPR) is an important adaptive cellular response to increased protein synthesis.
Tatiana V. Boyko +8 more
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The Unraveling Truth About IRE1 and MicroRNAs in Diabetes [PDF]
Diabetes, 2016 Wound healing is a well-regulated complex process that occurs as a cellular response to injury and consists of four phases: hemostasis, inflammation, proliferation, and remodeling (1). Many factors, such as diabetes and obesity, interfere with these stages and lead to wound healing defect.
Souad, Belmadani, Khalid, Matrougui
openaire +2 more sources
Engineering ER-stress dependent non-conventional mRNA splicing
eLife, 2018 The endoplasmic reticulum (ER) protein folding capacity is balanced with the protein folding burden to prevent accumulation of un- or misfolded proteins.
Weihan Li +6 more
doaj +1 more source
Inhibition of IRE1 modifies effect of glucose deprivation on the expression of TNFα-related genes in U87 glioma cells [PDF]
The Ukrainian Biochemical Journal, 2015 Inhibition of IRE1 (inositol requiring enzyme-1), the major signaling pathway of endoplasmic reticulum stress, significantly decreases glioma cell proliferation and tumor growth.
I. V. Kryvdiuk +5 more
doaj +1 more source
In vitro RNA Cleavage Assays to Characterize IRE1-dependent RNA Decay
Bio-Protocol, 2019 The kinase/RNase IRE1 is a key effector of the cellular response to endoplasmic reticulum stress. The RNase activity of IRE1 can be measured in cells or in the test tube.
G. Karagöz +3 more
doaj +1 more source
OVEREXPRESSION OF DOMINANT-NEGATIVE IRE1 ENZYME IN H1299-shE6AP CELLS INCREASES HEAT SHOCK ELEMENT-DEPENDENT TRANSCRIPTION [PDF]
Biotechnologia Acta, 2015 To investigate IRE1-dependent branch of endoplasmic reticulum stress pathway in various cancer cells we created cDNA-constructs for expression of dominant-negative inositol-requiring enzyme – 1 IRE1 and cytosolic domain of IRE1 fused on a C-terminus with
D. O. , О. H.
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Plant biotechnology (Tokyo, Japan), 2022 The unfolded protein response (UPR) or the endoplasmic reticulum (ER) stress response is a homeostatic cellular response conserved in eukaryotes to alleviate the accumulation of unfolded proteins in the ER. In the present study, we characterized the UPR in the liverwort Marchantia polymorpha to obtain insights into the conservation and divergence of ...
Takeda, Sho +5 more
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Chaperone BiP controls ER stress sensor Ire1 through interactions with its oligomers
Life Science AllianceActivation of the stress sensor Ire1 is triggered by stress-induced conformational changes in its luminal domains that promote Ire1 oligomerization.
Sam Dawes +10 more
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