Results 71 to 80 of about 19,138 (225)

Unique evolution of the UPR pathway with a novel bZIP transcription factor, Hxl1, for controlling pathogenicity of Cryptococcus neoformans. [PDF]

PLoS Pathogens, 2011
In eukaryotic cells, the unfolded protein response (UPR) pathway plays a crucial role in cellular homeostasis of the endoplasmic reticulum (ER) during exposure to diverse environmental conditions that cause ER stress. Here we report that the human fungal
Seon Ah Cheon, Kwang-Woo Jung, Ying-Lien Chen, Joseph Heitman, Yong-Sun Bahn, Hyun Ah Kang   +5 more
doaj   +1 more source

Air Pollution Quinones Impair Intestinal Barrier Integrity and Endoplasmic Reticulum in Differentiated Caco‐2 Cells

Journal of Applied Toxicology, EarlyView.
ABSTRACT Particulate matter (PM) is a major global health threat, linked to millions of deaths annually. Beyond inhalation, PM components reach the gastrointestinal tract through the mucociliary escalator or contaminated food and water. Among PM's organic fraction, redox‐active quinones such as 1,2‐naphthoquinone (NQ) and 9,10‐phenanthrenequinone (PQ ...
Franco Cervellati, Giulia Trinchera, Alice Casoni, Alessandra Pecorelli, Mascia Benedusi, Maria Chiara Pietrogrande, Giuseppe Valacchi   +6 more
wiley   +1 more source

Metabolic Dysfunction‐Associated Steatotic Liver Disease and Obesity: Pathogenesis, Diagnostics, Risk Stratification, and Therapeutic Approach

The Kaohsiung Journal of Medical Sciences, EarlyView.
ABSTRACT Metabolic dysfunction‐associated steatotic liver disease (MASLD) has emerged as the most prevalent chronic liver disease worldwide, closely linked to the global rising incidence of obesity and metabolic syndrome. This review synthesizes current evidence on the pathogenesis, gut–liver axis, and multidisciplinary management of MASLD within the ...
Beom Kyung Kim
wiley   +1 more source

Ubiquitination of Inositol-requiring Enzyme 1 (IRE1) by the E3 Ligase CHIP Mediates the IRE1/TRAF2/JNK Pathway [PDF]

Journal of Biological Chemistry, 2014
Deciphering the inositol-requiring enzyme 1 (IRE1) signaling pathway is fundamentally important for understanding the unfolded protein response (UPR). The ubiquitination of proteins residing on the endoplasmic reticulum (ER) membrane has been reported to be involved in the UPR, although the mechanism has yet to be fully elucidated.
Xu, Zhu, Ju, Zhang, Huiying, Sun, Cuicui, Jiang, Yusheng, Dong, Qiang, Shan, Siyuan, Su, Yingying, Xie, Ningzhi, Xu, Xiaomin, Lou, Siqi, Liu   +10 more
openaire   +2 more sources

Extracellular vesicles in pharmacology: Innovations in drug delivery and therapeutic applications in cancer

British Journal of Pharmacology, EarlyView.
Extracellular vesicles (EVs) are a diverse population of membrane nanoparticles secreted by nearly all cell types, playing a key role in intercellular communication by transferring bioactive macromolecular cargo. In cancer, EVs shape both the local tumour microenvironment and distant premetastatic niches.
Evangelia Pantazaka, Georgios Sivvas, Evangelia Papadimitriou, Constantinos M. Mikelis   +3 more
wiley   +1 more source

IRE1 functions and inhibition by M50 and UL50.

, 2013
Accumulation of unfolded proteins in the ER leads to recruitment of chaperones such as BiP and activation of ER stress sensors such as IRE1. (A) IRE1 dimerizes, autophosphorylates itself, and activates an endoribonuclease activity, which mediates Xbp1 ...
Julia M. Burkhart (443213), René P. Zahedi (443215), Matthias Budt (382049), Wolfram Brune (185524), Sebastian Stahl (443212), Hermine Mohr (160119), Florian Hinte (443214), Boaz Tirosh (204714), Zsolt Ruzsics (75383), Albert Sickmann (5325)   +9 more
core   +1 more source

Regulated Ire1-dependent decay of messenger RNAs in mammalian cells [PDF]

, 2009
Maintenance of endoplasmic reticulum (ER) function is achieved in part through Ire1 (inositol-requiring enzyme 1), a transmembrane protein activated by protein misfolding in the ER. The cytoplasmic nuclease domain of Ire1 cleaves the messenger RNA (mRNA)
Peter Walter, Lin, Jonathan H, Nicole Stevens, Stevens, Nicole, Li, Han, Julie Hollien, Jonathan H. Lin, Jonathan S. Weissman, Walter, Peter, Hollien, Julie, Weissman, Jonathan S, Han Li   +11 more
core   +1 more source

Dissection of Ire1 functions reveals stress response mechanisms uniquely evolved in Candida glabrata.

PLoS Pathogens, 2013
Proper protein folding in the endoplasmic reticulum (ER) is vital in all eukaryotes. When misfolded proteins accumulate in the ER lumen, the transmembrane kinase/endoribonuclease Ire1 initiates splicing of HAC1 mRNA to generate the bZIP transcription ...
Taiga Miyazaki, Hironobu Nakayama, Yohsuke Nagayoshi, Hiroshi Kakeya, Shigeru Kohno   +4 more
doaj   +1 more source

A Specific tRNA Half, 3'tiRNA‐GlyGCC, Regulates Hypoxic Pulmonary Artery Smooth Muscle Cell Proliferation via Myrf‐Mediated Endoplasmic Reticulum Stress

Cell Proliferation, EarlyView.
A schematic diagram illustrating how 3′tiRNA‐GlyGCC promotes the endoplasmic reticulum stress (ERS) and proliferation in hypoxic pulmonary artery smooth muscle cells (PASMCs) by inhibiting the expression of myelin regulatory factor (Myrf), ultimately leading to pulmonary hypertension (PH).
Lixin Zhang, Xiaoyu Guan, Xiangrui Zhu, Yingying Hao, Ya Xu, Hao Yuan, Danni Gao, Hongxia Du, Jiayu Li, Weiwei Cao, Cui Ma, Xiaoying Wang   +11 more
wiley   +1 more source

IRE1-mediated miRNA maturation in macrophage phosphoinositide signaling

, 2020
International audienceEndoplasmic reticulum (ER) stress signaling has long been associated with various pathological states in particular with the development of diseases with an underlying inflammation, such as diabetes, liver or cardiovascular ...
Tony Avril, Avril, Tony, Eric Chevet, Chevet, Eric   +3 more
core   +1 more source