Results 81 to 90 of about 19,138 (225)
Bilayer tension-induced clustering of the UPR sensor IRE1
, 2023 The endoplasmic reticulum serves as a center for protein quality control, where chaperones and foldases facilitate protein folding. IRE1 is a transmembrane protein that transduces proteotoxic stress signals by forming clusters and activating the ...
Hossain, Md Zobayer
core +1 more source
The FEBS Journal, EarlyView.We investigated the potential of iloperidone as an activator of Sigma‐1 receptor (S1R) neuroprotective function in juvenile Huntington's disease (jHD). We tested iloperidone on cortical neurons differentiated from patient‐derived iPSCs, demonstrating that it acts as a S1R agonist, decreasing apoptosis, huntingtin aggregation, and oxidative stress ...
Ersilia Fornetti +11 more
wiley +1 more source
Interferon regulatory factor 4 mediates nonenzymatic IRE1 dependency in multiple myeloma cells.
PLoS BiologyMultiple myeloma (MM) arises through oncogenic transformation of immunoglobulin-secreting plasma cells. MM often co-opts the central endoplasmic reticulum (ER)-stress mitigator, inositol-requiring enzyme 1 (IRE1), to sustain malignant growth.
Ioanna Oikonomidi +9 more
doaj +1 more source
PLoS ONE, 2013 The membrane of the endoplasmic reticulum (ER) of a cell forms contacts directly with mitochondria whereby the contact is referred to as the mitochondrion-associated ER membrane or the MAM.
Tomohisa Mori +3 more
doaj +1 more source
Cell Reports, 2013 The unfolded protein response (UPR) is composed by homeostatic signaling pathways that are activated by excessive protein misfolding in the endoplasmic reticulum.
Dina S. Coelho +7 more
doaj +1 more source
Expression of IGFBP6, IGFBP7, NOV, CYR61, WISP1 and WISP2 genes in U87 glioma cells in glutamine deprivation condition [PDF]
The Ukrainian Biochemical Journal, 2016 We have studied gene expression of insulin-like growth factor binding proteins in U87 glioma cells upon glutamine deprivation depending on the inhibition of IRE1 (inositol requiring enzyme-1), a central mediator of endoplasmic reticulum stress.
O. H. Minchenko +3 more
doaj +1 more source
Proteostasis in the regulation of pancreatic islet cell plasticity
Journal of Diabetes Investigation, EarlyView.Adaptive proteostasis integrates protein synthesis, folding, trafficking, and degradation through ISR, UPR, ER stress responses, autophagy, and proteasomal degradation. In pancreatic islet cells, this coordinated network preserves protein quality, secretory function, proliferation, and survival, enabling adaptation to metabolic stress and aging while ...
Jun Shirakawa
wiley +1 more source
, 2022 Additional file 5: Fig. S3. Validation of putative IRE1 substrates. Exon-usage plots of the 28 remaining putative mRNAs, showing the number of reads in mock (red) and IRE1-treated (blue) samples. The black arrows represent the site of primers used in the
Quwaider, Dalia +17 more
core +1 more source
Innovations in Obesity Treatment: Beyond Adipose Tissue Dysfunction
Obesity Reviews, EarlyView.Obesity drives chronic inflammation, insulin resistance, type 2 diabetes, and cancer development through adipocyte dysfunction. Addressing this multisystemic disorder requires integrated strategies beyond diet and exercise, such as thermogenesis activation via menthol or capsinoids and appetite control through GLP‐1/GIP agonists and neuromodulation to ...
Jesica Martínez‐Godfrey +7 more
wiley +1 more source
Sigma-1 receptors stabilize IRE1.
, 2013 (a) Sig-1R knockdown decreases phosphorylated IRE1 (pIRE1) in various types of cells when cells are under ER stress. Two days after the transfection of control siRNA (siCon) or Sig-1R siRNA (siSig-1R), cells were treated with thapsigargin (Tg) at 1 µM ...
Tomohisa Mori (474320) +3 more
core +1 more source