Results 101 to 110 of about 19,138 (225)

Pharmacological inhibition of the PERK pathway modulates hepatocellular carcinoma growth and immune signaling

FEBS Open Bio, Volume 16, Issue 9, Page 1766-1785, September 2026.
Pharmacological inhibition of PERK in a DEN‐induced mouse model of liver cancer does not reduce tumor burden but alters cellular stress signaling. Despite blocking PERK activity, downstream stress responses, including CHOP expression, remain active, suggesting compensatory mechanisms within the unfolded protein response that may influence tumor ...
Ada Lerma‐Clavero, Maria Kopsida, Nathalie Arendt, Hans Lennernäs, Markus Sjöblom, Femke Heindryckx   +5 more
wiley   +1 more source

Intrinsically Mitochondria‐Targeting Nanozyme via Coordination‐Assembly of Natural Quercetin for Cascade Antioxidant Therapy of Cerebral Ischemia‐Reperfusion Injury

Advanced Science, Volume 13, Issue 50, 7 September 2026.
This study uncovers that quercetin naturally targets mitochondria. By coordinating quercetin with Fe3+, we engineer an ultrasmall cascade nanozyme (MCN) with superoxide dismutase‐catalase activities. MCN crosses the damaged blood–brain barrier, scavenges mitochondrial ROS, prevents mitochondrial DNA leakage, and blocks the cGAS‐STING pathway, thereby ...
Wenxuan Zheng, Zhicheng Wang, Xin Zhou, Shuya Wang, Xiaojing Shi, Tingli Xiong, Ruishi Li, Yuting Lin, Zhen Chen, Jiawen Wei, Fei Li, Jinwen Ge, Kelong Ai, Chong Liu, Guiming Deng   +14 more
wiley   +1 more source

Basal IKK activity is decreased in cells lacking IRE1.

, 2012
(A) Cells lacking IRE1 have lower basal IKK activity. IRE1+/+ (closed circle) and ire1−/− (open circle) MEFs were treated with MG132 for up to 60 min, and P-IκBα, total IκBα, and actin were measured by Western Blot.
Alexander Hoffmann (124170), Ellen L. Mercado (124168), Arvin B. Tam (124164), Maho Niwa (7152)   +3 more
core   +1 more source

IRE1-bZIP60 Pathway Is Required for Nicotiana attenuata Resistance to Fungal Pathogen Alternaria alternata

Frontiers in Plant Science, 2019
As an endoplasmic reticulum (ER) stress sensor, inositol-requiring enzyme 1 (IRE1) splices the bZIP60 mRNA, and produces an active bZIP60 transcription factor that regulates genes involved in the unfolded protein response (UPR) during ER stresses.
Zhen Xu, Na Song, Na Song, Lan Ma, Jinsong Wu   +4 more
doaj   +1 more source

Inhibition of KDEL Receptors Remodels the Tumor Microenvironment for T Cell Independent Tumor Regression

Advanced Science, Volume 13, Issue 51, 14 September 2026.
Inhibition of KDELR2 in a small fraction of tumor cells generates sustainable immunogenic cell death conditions within the tumor microenvironment. These conditions promote the regression of tumors in a T cell independent manner. During regression, macrophages prime T cells that subsequently provide systemic protection against recurrence. The potency of
Shakti P Pattanayak, Hong Wang, Belinda Willard, Timothy A. Chan, William C Merrick, Zheng‐Rong Lu, Boaz Tirosh   +6 more
wiley   +1 more source

Molecular and Cellular Hallmarks of Age‐Related Vestibular Hair Cell Degeneration

Advanced Science, Volume 13, Issue 53, 24 September 2026.
This study utilizes single‐cell RNA‐seq transcriptomes, advanced imaging, and electrophysiology to examine universal and cell‐type‐specific aging signatures of vestibular hair cells. The study shows that impaired hair bundle function is a key driver of age‐related vestibular dysfunction.
Samadhi Kulasooriya, Huizhan Liu, Sarath Vijayakumar, Celia Bloom, Zhenhang Xu, Shu Tu, Benjamin J. Borgmeier, Mi Zhou, Litao Tao, Bechara Kachar, David Z. He   +10 more
wiley   +1 more source

QRICH1 Suppresses Glioma Progression by Inducing ER Stress and Activating the PERK‐ATF4‐CHOP Pathway

Cancer Medicine, Volume 15, Issue 9, September 2026.
ABSTRACT Background ER stress (ERS) influences tumor behavior through the unfolded protein response (UPR), yet its role in glioma is not fully defined. This study investigated the function of the ERS‐related regulator QRICH1 in glioma progression. Methods Public databases (TCGA and GTEx) were used to evaluate QRICH1 expression, survival, and prognostic
Yunjiang Wang, Min Xu, Zhenglou Chen, Xuqi Huo, Ya Xue, Xiang Ji, Yang Shen, Hongsheng Wang   +7 more
wiley   +1 more source

Computer-aided peptide-based drug design for inositol-requiring enzyme 1

Basic & Clinical Cancer Research, 2023
Inositol-requiring enzyme 1 (IRE1), an endoplasmic reticulum (ER) transmembrane protein with both kinase and endoribonuclease activities, plays an essential role during ER stress and its subsequent unfolded protein response (UPR).
Alireza Ghanbari, Amir Norouzy, Negar Balmeh, Najaf Allahyari Fard, Mohammad Amin Moosavi   +4 more
doaj  

Nanoplastic Particle Exposure Induces Toxicity and Amplifies Cellular Stress in THP‐1 Macrophages: Insights on Molecular Pathways and Circulating Proteome Interaction

Journal of Biochemical and Molecular Toxicology, Volume 40, Issue 9, September 2026.
Polystyrene nanoplastic particles (NPPs) interact with serum proteins, establishing nano‐bio interactions and triggering ROS‐mediated macrophage toxicity in THP‐1 cells, characterized by oxidative stress, mitochondrial dysfunction, apoptosis and stress‐signaling.
Balamurali Mahalakshmi, Gobichettipalayam Balasubramaniam Maadurshni, Thittumpuram Manikandan Anjana, Jeganathan Manivannan   +3 more
wiley   +1 more source

Production of the High Value Pharmaceutical Target, Human Granulocyte‐Colony Stimulating Factor, in Nicotiana benthamiana Is Improved by Co‐Expression of the Transcriptional Regulator of the Unfolded Protein Response, bZIP60

Plant Biotechnology Journal, EarlyView.
Nazgul Wagner, Konstantin Musiychuk, Stephen Tottey, Jukka Kervinen, Hong Bi, Stephen J. Streatfield, Rainer Fischer, Vidadi Yusibov   +7 more
wiley   +1 more source