Results 101 to 110 of about 15,549 (206)

Canonical and non‐canonical functions of proteins regulating mitochondrial dynamics in mammalian physiology

The Journal of Physiology, EarlyView.
Abstract figure legend Mitochondria are highly dynamic organelles that continuously remodel their architecture through coordinated cycles of fusion and fission. This review examines the four key GTPases that orchestrate mitochondrial dynamics in mammals: MFN1, MFN2, OPA1, and DRP1.
Rémi Chaney, Vincent Marcangeli, Krystel Desjardins, Shima Taherkhani, Gilles Gouspillou   +4 more
wiley   +1 more source

Tweaking Ire1 to Unlock Autophagy in Yeast

Autophagy Reports, 2023
Eshita Das, Ipsita Roy
openaire   +3 more sources

IRE1-bZIP60 Pathway Is Required for Nicotiana attenuata Resistance to Fungal Pathogen Alternaria alternata

Frontiers in Plant Science, 2019
As an endoplasmic reticulum (ER) stress sensor, inositol-requiring enzyme 1 (IRE1) splices the bZIP60 mRNA, and produces an active bZIP60 transcription factor that regulates genes involved in the unfolded protein response (UPR) during ER stresses.
Zhen Xu, Na Song, Na Song, Lan Ma, Jinsong Wu   +4 more
doaj   +1 more source

The UPR branch IRE1-bZIP60 in plants plays an essential role in viral infection and is complementary to the only UPR pathway in yeast.

PLoS Genetics, 2015
The unfolded protein response (UPR) signaling network encompasses two pathways in plants, one mediated by inositol-requiring protein-1 (IRE1)-bZIP60 mRNA and the other by site-1/site-2 proteases (S1P/S2P)-bZIP17/bZIP28.
Lingrui Zhang, Hui Chen, Federica Brandizzi, Jeanmarie Verchot, Aiming Wang   +4 more
doaj   +1 more source

Global Fluoride Toxicology Landscape: Bibliometric Approaches and Scientific Mapping

Environmental Toxicology, Volume 41, Issue 7, Page 416-458, July 2026.
ABSTRACT This study analyzed research trends in the 100 most‐cited articles on fluoride toxicology, a topic widely debated due to the toxic effects associated with levels deemed safe for human exposure. A bibliometric analysis was conducted using the Web of Science‐Core Collection, extracting data such as citation count, authors, keywords, journal ...
Maria Karolina Martins Ferreira, Deiweson Souza‐Monteiro, Priscila Cunha Nascimento, Luciana Eiró‐Quirino, Leonardo Oliveira Bittencourt, Fatemeh Vida Zohoori, Esperanza Angeles Martinez‐Mier, Marilia Afonso Rabelo Buzalaf, Rafael Rodrigues Lima   +8 more
wiley   +1 more source

A Bioluminescent Reporter System for Real‐Time Monitoring of the Unfolded Protein Response in Plants

Plant Biotechnology Journal, Volume 24, Issue 7, Page 4468-4470, July 2026.
ABSTRACT The unfolded protein response (UPR) is a critical mechanism for maintaining endoplasmic reticulum (ER) homeostasis under stress. Here, we developed a bioluminescent reporter system, AtbZIP60‐LUC, in Arabidopsis to dynamically monitor ER stress by coupling IRE1‐mediated splicing of bZIP60 mRNA to firefly luciferase (LUC) expression.
Yao Liu, Yue Niu, Yunxi Zhao, Wenwen Zhang, Yonglun Lv, Minqing Liu, Qian Zhang, Jiaojiao Wang, Xin Zhang, Yanjie Li, Hui Zhang, Yingying Zhang, Yan Bao   +12 more
wiley   +1 more source

Computer-aided peptide-based drug design for inositol-requiring enzyme 1

Basic & Clinical Cancer Research, 2023
Inositol-requiring enzyme 1 (IRE1), an endoplasmic reticulum (ER) transmembrane protein with both kinase and endoribonuclease activities, plays an essential role during ER stress and its subsequent unfolded protein response (UPR).
Alireza Ghanbari, Amir Norouzy, Negar Balmeh, Najaf Allahyari Fard, Mohammad Amin Moosavi   +4 more
doaj  

Intestinal IRE1 Is Required for Increased Triglyceride Metabolism and Longer Lifespan under Dietary Restriction

Cell Reports, 2016
Summary: Dietary restriction (DR) is one of the most robust lifespan-extending interventions in animals. The beneficial effects of DR involve a metabolic adaptation toward increased triglyceride usage.
Nuno Miguel Luis, Lifen Wang, Mauricio Ortega, Hansong Deng, Subhash D. Katewa, Patrick Wai-Lun Li, Jason Karpac, Heinrich Jasper, Pankaj Kapahi   +8 more
doaj   +1 more source

Differential regulation of ZFAS1 splice variants by endoplasmic reticulum stress in hepatocyte cell lines

FEBS Open Bio, Volume 16, Issue 6, Page 1115-1131, June 2026.
ZFAS1 is a lncRNA promoting cell proliferation and migration, exhibiting high expression in various cancers. It is conserved, widely expressed, and produces multiple splice variants with unclear roles. We identified several splice variants in hepatocyte models, and found that inhibiting or suppressing regulators of the unfolded protein response (PERK ...
Sébastien Soubeyrand, Paulina Lau, Ruth McPherson   +2 more
wiley   +1 more source

Tetrastigma Hemsleyanum Polysaccharide Suppresses Triple‐Negative Breast Cancer by Disrupting the Hippo‐YAP/TEAD4‐PDIA4 Axis and Endoplasmic Reticulum Stress Adaptation

Advanced Science, Volume 13, Issue 34, 19 June 2026.
ABSTRACT Triple‐negative breast cancer (TNBC) exhibits addiction to chronic endoplasmic reticulum (ER) stress, which sustains an aggressive metastatic phenotype through activation of the unfolded protein response (UPR). Here, we identify a previously unrecognized “ER‐stress addiction” axis in which the Hippo pathway effector TEAD4 directly ...
Yini Shang, Wentao Si, Youxue Zhang, Jialin Liu, Huaixi Zhang, Yafei Li, Hongmeng Su, Wei Jiang, Zhishan Ding, Lihong Wang   +9 more
wiley   +1 more source