Results 121 to 130 of about 19,138 (225)

Proteostasis of organelles in aging and disease

The FEBS Journal, Volume 293, Issue 18, Page 5600-5626, September 2026.
Cells rely on regulated proteostasis mechanisms to keep their internal compartments functioning properly. When these mechanisms fail, damaged proteins accumulate, disrupting organelles, such as the nucleus, mitochondria, endoplasmic reticulum, Golgi, and lysosomes, as well as membraneless organelles, such as stress granules, processing bodies, the ...
Yara Nabawi, Cansu Doğan, Dunja Petrović, Gülce Perçin, Seda Koyuncu, David Vilchez   +5 more
wiley   +1 more source

Biogenesis of TNF‐α‐insights into proteostasis and inflammation

The FEBS Journal, Volume 293, Issue 18, Page 5645-5663, September 2026.
TNF‐α biogenesis, trafficking, and signalling are tightly and reciprocally coupled to cellular proteostasis systems, including ER chaperones and endoplasmic reticulum‐associated degradation. This bidirectional crosstalk determines whether TNF‐α responses are adaptive or proteotoxic.
Bailasan Haidar, Céline Philippe, Eric Chevet, Jiří Zahradník   +3 more
wiley   +1 more source

SIB1‐SEC23A undergo ER to chloroplast relocalization to mediate immunity in Arabidopsis thaliana

Journal of Integrative Plant Biology, Volume 68, Issue 9, Page 3458-3472, September 2026.
SEC23A mediates membrane trafficking between the endoplasmic reticulum (ER) and Golgi apparatus and interacts with the immunity protein SIGMA FACTOR‐BINDING PROTEIN1 in Arabidopsis. Under stress, both proteins relocate from the ER to chloroplasts, suppressing photosynthesis genes and enhancing defense genes.
Jialin Peng, Huan Zhong, Jianan Zhang, Hailei Zhang, Wuzhen Liu, Yonglun Zeng, Liwen Jiang, Yiji Xia   +7 more
wiley   +1 more source

IRE1 RNase controls CD95-mediated cell death

International audienceSignalling by the Unfolded Protein Response (UPR) or by the Death Receptors (DR) are frequently activated towards pro-tumoral outputs in cancer.
Papaioannou, Alexandra, Alexandra Papaioannou, Victoria Maltret, Raphael Pineau, Flavie Caradec, Sophie Martin, Pineau, Raphaël, Chevet, Eric, Lafont, Elodie, Manon Nivet, Elodie Lafont, Matthieu Le Gallo, Zhou, Xingchen, Nivet, Manon, Caradec, Flavie, Martin, Sophie, Diana Pelizzari-Raymundo, Le Gallo, Matthieu, Tony Avril, Pelizzari Raymundo, Diana, Avril, Tony, Maltret, Victoria, Xingchen Zhou, Eric Chevet   +23 more
core   +1 more source

IRE1 [PDF]

Developmental Cell, 2003
openaire   +1 more source

Modulation of the IRE1-XBP1 pathway by HCMV UL50.

, 2013
(A) 293A cells were cotransfected with plasmids expressing HA-tagged murine or human IRE1 and Flag-tagged M50, UL56, NEMO, or UL50 respectively. Cell lysates were harvested 24 h after transfection.
Julia M. Burkhart (443213), René P. Zahedi (443215), Matthias Budt (382049), Wolfram Brune (185524), Sebastian Stahl (443212), Hermine Mohr (160119), Florian Hinte (443214), Boaz Tirosh (204714), Zsolt Ruzsics (75383), Albert Sickmann (5325)   +9 more
core   +1 more source

The IRE1-XBP1s Pathway Impairment Underpins NK Cell Dysfunction in Hodgkin Lymphoma, That Is Partly Restored By PD-1 Blockade

, 2019
Background: The frequent loss of Major Histocompatibility Complex I molecule (MHC-I) on Hodgkin/Reed-Sternberg (HRS)-cells renders them susceptible to Natural Killer (NK) cell-mediated lysis in Hodgkin Lymphoma (HL).
Cristino, Alexandre, Nourse, Jamie, Gandhi, Maher K, Bednarska, Karolina, Vari, Frank, Stehbens, Samantha, Mujaj, Sally, Thillaiyampalam, Gayathri, Cui, Qingyan, Gunawardana, Jay   +9 more
core   +1 more source

Dietary influences on chemotherapy sensitivity and cardiotoxicity modulated by IRE1 targeting in triple‐negative breast cancer in female mice

Physiological Reports
Triple‐negative breast cancer (TNBC) predominantly affects young and minority women, with cytotoxic chemotherapy regimens causing severe side effects, including chronic cardiac dysfunction. Obesity worsens TNBC survival. Inositol‐requiring enzyme‐1 (IRE1)
Yismeilin R. Feliz‐Mosquea, Adam S. Wilson, Nildris Cruz‐Diaz, Valerie S. Payne, Katherine L. Cook, David R. Soto‐Pantoja   +5 more
doaj   +1 more source

Tongguanteng injection exerts anti-osteosarcoma effects through the ER stress-associated IRE1/CHOP pathway

BMC Complementary Medicine and Therapies
Background In China, Tongguanteng injection (TGT) is widely used in the treatment or adjuvant treatment of various types of cancer. However, the effect and mechanism of TGT in osteosarcoma is not clear.
Xiao-Chuan Xue, Yang-Yun Zhou, Ling-Yan Xu, Lan-Yi Wei, Yu-Jie Hu, Jiao Yang, Xiang-Qi Zhang, Meng-Yue Wang, Yong-Long Han, Jun-Jun Chen   +9 more
doaj   +1 more source

IRE1’in metaflamasyon ve aterosklerozdaki rolü

, 2017
Cataloged from PDF version of article.Includes bibliographical references (leaves 134-158).Chronic metabolic overloading of anabolic and catabolic organelles such as the endoplasmic reticulum (ER) and mitochondria is a major cause of inflammation in ...
Tufanlı, Özlem
core