Results 31 to 40 of about 33,130 (117)
Unfolded Protein Responses With or Without Unfolded Proteins?
Cells, 2012 The endoplasmic reticulum (ER) is the site of secretory protein biogenesis. The ER quality control (QC) machinery, including chaperones, ensures the correct folding of secretory proteins.
Erik L. Snapp
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Surveillance-activated defenses block the ROS-induced mitochondrial unfolded protein response. [PDF]
PLoS Genetics, 2013 Disturbance of cellular functions results in the activation of stress-signaling pathways that aim at restoring homeostasis. We performed a genome-wide screen to identify components of the signal transduction of the mitochondrial unfolded protein response
Eva D Runkel +3 more
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PLoS Pathogens, 2008 Pore-forming toxins (PFTs) constitute the single largest class of proteinaceous bacterial virulence factors and are made by many of the most important bacterial pathogens. Host responses to these toxins are complex and poorly understood. We find that the
Larry J Bischof +7 more
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The Role of Endoplasmic Reticulum Stress Response in Pollen Development and Heat Stress Tolerance
Frontiers in Plant Science, 2021 Endoplasmic reticulum (ER) stress is defined by a protracted disruption in protein folding and accumulation of unfolded or misfolded proteins in the ER.
Mohan B. Singh +2 more
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Endoplasmic Reticulum Stress in Intestinal Epithelial Cell Function and Inflammatory Bowel Disease
Gastroenterology Research and Practice, 2015 In eukaryotic cells, perturbation of protein folding homeostasis in the endoplasmic reticulum (ER) causes accumulation of unfolded and misfolded proteins in the ER lumen, which activates intracellular signaling pathways termed the unfolded protein ...
Katherine Luo, Stewart Siyan Cao
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Conserved and Plant-Unique Strategies for Overcoming Endoplasmic Reticulum Stress
Frontiers in Plant Science, 2014 Stress caused by environmental conditions or physiological growth can lead to an accumulation of unfolded proteins in the endoplasmic reticulum (ER) causing ER stress, which in turn triggers a cytoprotective mechanism termed the unfolded protein response
Cristina eRuberti +3 more
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Zhangfei/CREB-ZF - a potential regulator of the unfolded protein response. [PDF]
PLoS ONE, 2013 Cells respond to perturbations in the microenvironment of the endoplasmic reticulum (ER), and to the overloading of its capacity to process secretory and membrane-associate proteins, by activating the Unfolded Protein Response (UPR).
Rui Zhang +6 more
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The unfolded protein response signaling pathways in molluscs
Invertebrate Survival Journal, 2018 Unfolded protein response (UPR) as collective signal transduction pathways is essential for surviving the endoplasmic reticulum (ER) stress in vertebrates and invertebrates.
Y Huang, J Sun, L Wang, L Song
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Dual role for the unfolded protein response in the ovary: adaption and apoptosis
Protein & Cell, 2016 The endoplasmic reticulum (ER) is the principal organelle responsible for several specific cellular functions including synthesis and folding of secretory or membrane proteins, lipid metabolism, and Ca2+ storage.
Ning Huang, Yang Yu, Jie Qiao
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Endoplasmic reticulum stress as target for treatment of hearing loss
STEMedicine, 2020 The endoplasmic reticulum (ER) plays pivotal roles in coordinating protein biosynthesis and processing. Under ER stress, when excessive misfolded or unfolded proteins are accumulated in the ER, the unfolded protein response (UPR) is activated.
Yanfei Wang, Zhigang Xu
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