Results 31 to 40 of about 8,105,112 (196)

Targeting the IRE1α/XBP1s pathway suppresses CARM1-expressing ovarian cancer

Nature Communications, 2021
The unfolded protein response (UPR) promotes cell survival in cancers with hyperactive ER stress response. Here the authors show that CARM1, an arginine methyltransferase, controls the IRE1α/XBP1 pathway of the UPR and the inhibition of this pathway can ...
Jianhuang Lin, Heng Liu, Takeshi Fukumoto, Joseph Zundell, Qingqing Yan, Chih-Hang Anthony Tang, Shuai Wu, Wei Zhou, Dajiang Guo, Sergey Karakashev, Chih-Chi Andrew Hu, Kavitha Sarma, Andrew V. Kossenkov, Rugang Zhang   +13 more
doaj   +1 more source

The Impact of Endoplasmic Reticulum-Associated Protein Modifications, Folding and Degradation on Lung Structure and Function

Frontiers in Physiology, 2021
The accumulation of unfolded/misfolded proteins in the endoplasmic reticulum (ER) causes ER stress and induces the unfolded protein response (UPR) and other mechanisms to restore ER homeostasis, including translational shutdown, increased targeting of ...
Emily M. Nakada, Emily M. Nakada, Rui Sun, Rui Sun, Utako Fujii, Utako Fujii, James G. Martin, James G. Martin   +7 more
doaj   +1 more source

The Endoplasmic Reticulum Unfolded Protein Response in Neurodegenerative Disorders and Its Potential Therapeutic Significance

Frontiers in Molecular Neuroscience, 2017
In eukaryotic cells, the endoplasmic reticulum (ER) is the cell compartment involved in secretory protein translocation and quality control of secretory protein folding.
Paolo Remondelli, Maurizio Renna
doaj   +1 more source

Endoplasmic Reticulum Stress and Lipid Metabolism: Mechanisms and Therapeutic Potential

Biochemistry Research International, 2012
The endoplasmic reticulum (ER) plays a crucial role in protein folding, assembly, and secretion. Disruption of ER homeostasis may lead to accumulation of misfolded or unfolded proteins in the ER lumen, a condition referred to as ER stress. In response to
Sana Basseri, Richard C. Austin
doaj   +1 more source

Cellular stress signaling and the unfolded protein response in retinal degeneration: mechanisms and therapeutic implications

Molecular Neurodegeneration, 2022
Background The retina, as part of the central nervous system (CNS) with limited capacity for self-reparation and regeneration in mammals, is under cumulative environmental stress due to high-energy demands and rapid protein turnover.
Todd McLaughlin, Andy Medina, Jacob Perkins, Maria Yera, Joshua J. Wang, Sarah X. Zhang   +5 more
doaj   +1 more source

Photoactivated Platinum Complexes: Targeting Membrane Proteins and Organelles for Precision Cancer Therapy

Angewandte Chemie, EarlyView.
This review highlights an emerging anticancer approach integrating platinum agents into photodynamic therapy (PDT) and photoactivated chemotherapy (PACT) systems, further augmented by cancer cell membrane‐ and organelle‐targeting. By directing photoactivated platinum complexes from nontargeted distribution to cancer cells or defined subcellular sites ...
Shu Chen, Qiyuan Zhou, Jiaqian Xu, Guangyu Zhu   +3 more
wiley   +2 more sources

Nuclear receptor LRH-1/NR5A2 is required and targetable for liver endoplasmic reticulum stress resolution [PDF]

, 2014
Chronic endoplasmic reticulum (ER) stress results in toxicity that contributes to multiple human disorders. We report a stress resolution pathway initiated by the nuclear receptor LRH-1 that is independent of known unfolded protein response (UPR ...
DeMayo, Fransesco J., San-Pin Wu, David D Moore, Moore, David D, Whitby, Richard J., Martin Wagner, Moore, David D., Peter J Stambrook, Whitby, Richard J, Sifers, Richard N, Ming-Jer Tsai, Francesco J DeMayo, Wu, San-pin, Mamrosh, Jennifer L, Jennifer L Mamrosh, Lee, Jae Man, Sifers, Richard N., Richard N Sifers, Richard J Whitby, Stambrook, Peter J, Stambrook, Peter J., Jae Man Lee, Wagner, Martin, Tsai, Ming-jer, Lee, Jae M., DeMayo, Francesco J, Mamrosh, Jennifer L.   +26 more
core   +1 more source

Unfolded protein response in cancer: the Physician's perspective

Journal of Hematology & Oncology, 2011
The unfolded protein response (UPR) is a cascade of intracellular stress signaling events in response to an accumulation of unfolded or misfolded proteins in the lumen of the endoplasmic reticulum (ER). Cancer cells are often exposed to hypoxia, nutrient
Li Zihai, Zhang Kezhong, Li Xuemei
doaj   +1 more source

The microbiome in human skin aging

FEBS Letters, EarlyView.
Age‐related skin changes encompass the well‐known visible phenotypic alterations, together with microbiome dysbiosis and a series of molecular aging hallmarks. These hallmarks characterize not only a fully stablished aged phenotype but also the skin aging process itself.
Manuel Huerta Arana, Cornelia Wiegand, Omid Omrani, Mario Fabri   +3 more
wiley   +1 more source

Autophagy and mitophagy in pancreatic β‐cell homeostasis and their involvement in diabetes pathophysiology

FEBS Letters, EarlyView.
This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee, Mingming Tong, Anna L. Gloyn   +2 more
wiley   +1 more source