Results 11 to 20 of about 33,130 (117)

Unfolded Protein Response (UPR) in Survival, Dormancy, Immunosuppression, Metastasis, and Treatments of Cancer Cells. [PDF]

Int J Mol Sci, 2019
Hsu SK, Chiu CC, Dahms HU, Chou CK, Cheng CM, Chang WT, Cheng KC, Wang HD, Wang HD, Lin IL.   +9 more
europepmc   +2 more sources

Endoplasmic Reticulum (ER) Stress and Unfolded Protein Response (UPR) in Mammalian Oocyte Maturation and Preimplantation Embryo Development. [PDF]

Int J Mol Sci, 2019
Lin T, Lee JE, Kang JW, Shin HY, Lee JB, Jin DI.   +5 more
europepmc   +2 more sources

Targeting Glioblastoma Stem Cells with 2-Deoxy-D-Glucose (2-DG) Potentiates Radiation-Induced Unfolded Protein Response (UPR). [PDF]

Cancers (Basel), 2019
Shah SS, Rodriguez GA, Musick A, Walters WM, de Cordoba N, Barbarite E, Marlow MM, Marples B, Prince JS, Komotar RJ, Vanni S, Graham RM.   +11 more
europepmc   +2 more sources

Temporal Transcript Profiling Identifies a Role for Unfolded Protein Stress in Human Gut Ischemia-Reperfusion InjurySummary

Cellular and Molecular Gastroenterology and Hepatology, 2022
Background & Aims: Intestinal ischemia-reperfusion injury is a serious and life-threatening condition. A better understanding of molecular mechanisms related to intestinal ischemia-reperfusion injury in human beings is imperative to find therapeutic ...
Anna M. Kip, Joep Grootjans, Marco Manca, M’hamed Hadfoune, Bas Boonen, Joep P.M. Derikx, Erik A.L. Biessen, Steven W.M. Olde Damink, Cornelis H.C. Dejong, Wim A. Buurman, Kaatje Lenaerts   +10 more
doaj   +1 more source

Investigation of the Molecular Mechanisms Leading to Protein Translation Inhibition in Response to Endoplasmic Reticulum Stress

مجلة المختار للعلوم, 2018
Protein folding is an important process for cellular function. ER is responsible for the synthesis, folding, modification, and quality control of numerous secretory and membrane proteins.
Abdulsalam Elfowiris, Terence P. Herbert   +1 more
doaj   +1 more source

ER Stress and the Unfolded Protein Response: Homeostatic Regulation Coordinate Plant Survival and Growth

Plants, 2022
The endoplasmic reticulum (ER), a eukaryotic organelle, is the major site of protein biosynthesis. The disturbance of ER function by biotic or abiotic stress triggers the accumulation of misfolded or unfolded proteins in the ER.
June-Sik Kim, Keiichi Mochida, Kazuo Shinozaki   +2 more
doaj   +1 more source

Noncanonical binding of BiP ATPase domain to Ire1 and Perk is dissociated by unfolded protein CH1 to initiate ER stress signaling

eLife, 2015
The unfolded protein response (UPR) is an essential cell signaling system that detects the accumulation of misfolded proteins within the endoplasmic reticulum (ER) and initiates a cellular response in order to maintain homeostasis.
Marta Carrara, Filippo Prischi, Piotr R Nowak, Megan C Kopp, Maruf MU Ali   +4 more
doaj   +1 more source

ER Stress and Unfolded Protein Response in Leukemia: Friend, Foe, or Both?

Biomolecules, 2021
The unfolded protein response (UPR) is an evolutionarily conserved adaptive signaling pathway triggered by a stress of the endoplasmic reticulum (ER) lumen compartment, which is initiated by the accumulation of unfolded proteins.
Kelly Féral, Manon Jaud, Céline Philippe, Doriana Di Bella, Stéphane Pyronnet, Kevin Rouault-Pierre, Laurent Mazzolini, Christian Touriol   +7 more
doaj   +1 more source

Using Arabidopsis Mesophyll Protoplasts to Study Unfolded Protein Response Signaling

Bio-Protocol, 2018
Various environmental stresses or artificial reagents can trigger unfolded protein accumulation in the endoplasmic reticulum (ER) due to the folding capacity of the ER being exceeded.
Yan Bao, Diane Bassham
doaj   +1 more source

A multi-omics analysis reveals the unfolded protein response regulon and stress-induced resistance to folate-based antimetabolites

Nature Communications, 2020
The unfolded protein response (UPR) is a stress response pathway implicated in numerous diseases and chemotherapy resistance. Here, the authors define the UPR regulon with a multi-omics strategy, uncovering changes to mitochondrial one-carbon metabolism ...
Stefan Reich, Chi D. L. Nguyen, Canan Has, Sascha Steltgens, Himanshu Soni, Cristina Coman, Moritz Freyberg, Anna Bichler, Nicole Seifert, Dominik Conrad, Christiane B. Knobbe-Thomsen, Björn Tews, Grischa Toedt, Robert Ahrends, Jan Medenbach   +14 more
doaj   +1 more source