Results 11 to 20 of about 8,105,112 (196)
Measurement of the unfolded protein response (UPR) in monocytes. [PDF]
, 2011 In mammalian cells, the primary function of the endoplasmic reticulum (ER) is to synthesize and assemble membrane and secreted proteins. As the main site of protein folding and posttranslational modification in the cell, the ER operates a highly ...
Noel G McElvaney (7895978) +2 more
core +3 more sources
The Unfolded Protein Response: An Overview
Biology, 2021 The unfolded protein response is the mechanism by which cells control endoplasmic reticulum (ER) protein homeostasis. Under normal conditions, the UPR is not activated; however, under certain stresses, such as hypoxia or altered glycosylation, the UPR ...
Adam Read, Martin Schröder
doaj +1 more source
Nature Communications, 2022 Endoplasmic reticulum stress activates the unfolded protein response (UPR). The authors show that glucose extends the lifespan of aged animals by activating the otherwise quiescent UPR while causing a UPR-dependent reduced longevity in young ...
Caroline Beaudoin-Chabot +9 more
doaj +1 more source
TP53 R249S mutation in hepatic organoids captures the predisposing cancer risk
Hepatology, EarlyView., 2022 The systematic approach in elucidating the gain‐of‐function (GOF) roles of TP53 mutations in early liver carcinogenesis. Unique downstream targets of TP53 L3 mutations were identified from chormatin immunoprecipitation sequencing in HCC cell lines, followed by a series of validation assays to substantiate the exclusive transcriptional regulations ...
Yin Kau Lam +10 more
wiley +1 more source
The Unfolded Protein Response and its potential role in Huntington's disease [PDF]
, 2012 Huntington's disease (HD) is a progressive, neurodegenerative disease with fatal outcome. Although the disease-causing gene (huntingtin) has been known for some time, the exact cause of neuronal cell death is still unknown.
Ravi K. R. Kalathur +2 more
core +1 more source
Gcn4p and novel upstream activating sequences regulate targets of the unfolded protein response. [PDF]
PLoS Biology, 2004 Eukaryotic cells respond to accumulation of unfolded proteins in the endoplasmic reticulum (ER) by activating the unfolded protein response (UPR), a signal transduction pathway that communicates between the ER and the nucleus.
Christopher K Patil +2 more
doaj +1 more source
Targeting Glioblastoma Stem Cells with 2-Deoxy-D-Glucose (2-DG) Potentiates Radiation-Induced Unfolded Protein Response (UPR) [PDF]
Cancers, 2019 Jeffrey S. Prince +2 more
exaly +2 more sources
Journal of Pharmacological Sciences, 2009 Activation of the unfolded protein response (UPR) has been suggested to attenuate renal ischemia-reperfusion (I/R) injury. We recently found a compound, namely BIX, that activated the UPR selectively through the activating transcription factor 6 pathway.
Worapat Prachasilchai +6 more
doaj +1 more source
Nature Communications, 2022 Endoplasmic Reticulum stress induces cell non-autonomous Unfolded Protein Response (UPR) activation. Here the authors show that long-chain ceramides are secreted from muscle cells in extracellular vesicles and induce cell non-autonomous UPR activation in
Ben D. McNally +15 more
doaj +1 more source
مجلة المختار للعلوم, 2018 Protein folding is an important process for cellular function. ER is responsible for the synthesis, folding, modification, and quality control of numerous secretory and membrane proteins.
Abdulsalam Elfowiris +1 more
doaj +1 more source