Results 21 to 30 of about 8,105,112 (196)

Endoplasmic reticulum stress and liver diseases

Liver Research, 2019
Endoplasmic reticulum (ER) stress occurs when ER homeostasis is perturbed with accumulation of unfolded/misfolded protein or calcium depletion. The unfolded protein response (UPR), comprising of inositol-requiring enzyme 1α (IRE1α), double-stranded RNA ...
Xiaoying Liu, Richard M. Green
doaj   +1 more source

Temporal Transcript Profiling Identifies a Role for Unfolded Protein Stress in Human Gut Ischemia-Reperfusion InjurySummary

Cellular and Molecular Gastroenterology and Hepatology, 2022
Background & Aims: Intestinal ischemia-reperfusion injury is a serious and life-threatening condition. A better understanding of molecular mechanisms related to intestinal ischemia-reperfusion injury in human beings is imperative to find therapeutic ...
Anna M. Kip, Joep Grootjans, Marco Manca, M’hamed Hadfoune, Bas Boonen, Joep P.M. Derikx, Erik A.L. Biessen, Steven W.M. Olde Damink, Cornelis H.C. Dejong, Wim A. Buurman, Kaatje Lenaerts   +10 more
doaj   +1 more source

The unfolded protein response and the biology of uveal melanoma

, 2022
Uveal melanoma (UM) is a highly metastatic ocular cancer that arises from the melanocytes of the uveal tract (the choroid, ciliary body and iris). Despite a growing understanding of UM biology, effective systemic treatments are currently lacking and the ...
Conway, R Max, Wang, Ke, Zhu, Xue, Murray, Michael, Cherepanoff, Svetlana, Zhou, Fanfan, Zhang, Stanley, Madigan, Michele C, Zhu, Ling   +8 more
core   +1 more source

ER Stress and the Unfolded Protein Response: Homeostatic Regulation Coordinate Plant Survival and Growth

Plants, 2022
The endoplasmic reticulum (ER), a eukaryotic organelle, is the major site of protein biosynthesis. The disturbance of ER function by biotic or abiotic stress triggers the accumulation of misfolded or unfolded proteins in the ER.
June-Sik Kim, Keiichi Mochida, Kazuo Shinozaki   +2 more
doaj   +1 more source

The unfolded protein response

, 2007
Protein folding is the rate-limiting step for secretion of recombinant proteins in nearly all expression systems. Overexpression of recombinant proteins easily exhausts the cellular protein folding machinery in the endoplasmic reticulum (ER).
Strudwick, N., Schröder, M.
core   +6 more sources

Noncanonical binding of BiP ATPase domain to Ire1 and Perk is dissociated by unfolded protein CH1 to initiate ER stress signaling

eLife, 2015
The unfolded protein response (UPR) is an essential cell signaling system that detects the accumulation of misfolded proteins within the endoplasmic reticulum (ER) and initiates a cellular response in order to maintain homeostasis.
Marta Carrara, Filippo Prischi, Piotr R Nowak, Megan C Kopp, Maruf MU Ali   +4 more
doaj   +1 more source

Connection between Unfolded Protein Response (UPR) and plant immunity [PDF]

, 2021
This bachelor thesis is concerned with the specific pathway in a response to endoplasmic reticulum stress in plant cells - the Unfolded Protein Response (UPR) and its role in plant immunity signalling.
Kapr, Jan
core  

ER Stress and Unfolded Protein Response in Leukemia: Friend, Foe, or Both?

Biomolecules, 2021
The unfolded protein response (UPR) is an evolutionarily conserved adaptive signaling pathway triggered by a stress of the endoplasmic reticulum (ER) lumen compartment, which is initiated by the accumulation of unfolded proteins.
Kelly Féral, Manon Jaud, Céline Philippe, Doriana Di Bella, Stéphane Pyronnet, Kevin Rouault-Pierre, Laurent Mazzolini, Christian Touriol   +7 more
doaj   +1 more source

A multi-omics analysis reveals the unfolded protein response regulon and stress-induced resistance to folate-based antimetabolites

Nature Communications, 2020
The unfolded protein response (UPR) is a stress response pathway implicated in numerous diseases and chemotherapy resistance. Here, the authors define the UPR regulon with a multi-omics strategy, uncovering changes to mitochondrial one-carbon metabolism ...
Stefan Reich, Chi D. L. Nguyen, Canan Has, Sascha Steltgens, Himanshu Soni, Cristina Coman, Moritz Freyberg, Anna Bichler, Nicole Seifert, Dominik Conrad, Christiane B. Knobbe-Thomsen, Björn Tews, Grischa Toedt, Robert Ahrends, Jan Medenbach   +14 more
doaj   +1 more source

A mechanism of ineffective erythropoiesis in β-thalassemia/Hb E disease

Haematologica, 2010
Background Cells respond to stress stimuli through a number of response pathways, of which one of the most important and well characterized is the unfolded protein response.
Pathrapol Lithanatudom, Amporn Leecharoenkiat, Tirawat Wannatung, Saovaros Svasti, Suthat Fucharoen, Duncan R. Smith   +5 more
doaj   +1 more source