Results 11 to 20 of about 1,308,915 (353)
Frontiers in Immunology, 2023 In cancer, activation of the IRE1/XBP1s axis of the unfolded protein response (UPR) promotes immunosuppression and tumor growth, by acting in cancer cells and tumor infiltrating immune cells.
Felipe Flores-Santibañez +21 more
doaj +1 more source
Current Status of Endoplasmic Reticulum Stress in Type II Diabetes
Molecules, 2021 The endoplasmic reticulum (ER) plays a multifunctional role in lipid biosynthesis, calcium storage, protein folding, and processing. Thus, maintaining ER homeostasis is essential for cellular functions.
Sagir Mustapha +13 more
doaj +1 more source
ER Stress and Angiogenesis [PDF]
Cell Metabolism, 2015 Proper tissue vascularization is vital for cellular function as it delivers oxygen, nutrients, hormones, and immune cells and helps to clear cellular debris and metabolic waste products. Tissue angiogenesis occurs to satisfy energy requirements and cellular sensors of metabolic imbalance coordinate vessel growth.
Binet, François, Sapieha, Przemyslaw
openaire +2 more sources
Animal Cells and Systems, 2023 Autophagy plays a critical role in regulating the quality and quantity of cellular compartments; however, the mechanisms governing endoplasmic reticulum (ER) autophagy (ER-phagy) are still largely undefined.
Joon Bum Kim +9 more
doaj +1 more source
Diversification and deleterious role of microbiome in gastric cancer
Cancer Reports, 2023 Gut microbiota dictates the fate of several diseases, including cancer. Most gastric cancers (GC) belong to gastric adenocarcinomas (GAC). Helicobacter pylori colonizes the gastric epithelium and is the causative agent of 75% of all stomach malignancies ...
Indranil Chattopadhyay +2 more
doaj +1 more source
Endogenous Anti-Cancer Candidates in GPCR, ER Stress, and EMT
Biomedicines, 2020 The majority of cellular responses to external stimuli are mediated by receptors such as G protein-coupled receptors (GPCRs) and systems including endoplasmic reticulum stress (ER stress).
Rohit Gundamaraju +4 more
doaj +1 more source
Frontiers in Cell and Developmental Biology, 2021 Alzheimer’s disease (AD) is the most common neurodegenerative disease, characterized by progressive cognitive impairment and memory loss. So far, the pathogenesis of AD has not been fully understood.
Xun Gao, Yuanyuan Xu
doaj +1 more source
ER stress in antigen‐presenting cells promotes NKT cell activation through endogenous neutral lipids [PDF]
, 2020 CD1d-restricted invariant natural killer T (iNKT) cells constitute a common glycolipid-reactive innate-like T-cell subset with a broad impact on innate and adaptive immunity.
Cheng, Tan‐Yun +12 more
core +2 more sources
Frontiers in Cellular and Infection Microbiology, 2022 The normal operation of the endoplasmic reticulum (ER) is critical for cells and organisms. However, ER stress, caused by imbalanced protein folding, occurs frequently, which perturbs the function of the ER and even results in cell apoptosis eventually ...
Peng Xu, Jing Tang, Zheng-Guo He
doaj +1 more source
ER Stress and Effects of DHA as an ER Stress Inhibitor [PDF]
Translational Stroke Research, 2013 The endoplasmic reticulum (ER) functions in the synthesis, folding, modification, and transport of newly synthesized transmembrane and secretory proteins. The ER also has important roles in the storage of intracellular Ca(2+) and regulation of Ca(2+) homeostasis.
Gulnaz, Begum +3 more
openaire +2 more sources