Results 11 to 20 of about 40,852 (216)

Diversification and deleterious role of microbiome in gastric cancer

Cancer Reports, 2023
Gut microbiota dictates the fate of several diseases, including cancer. Most gastric cancers (GC) belong to gastric adenocarcinomas (GAC). Helicobacter pylori colonizes the gastric epithelium and is the causative agent of 75% of all stomach malignancies ...
Indranil Chattopadhyay, Rohit Gundamaraju, Ashwin Rajeev   +2 more
doaj   +1 more source

Endogenous Anti-Cancer Candidates in GPCR, ER Stress, and EMT

Biomedicines, 2020
The majority of cellular responses to external stimuli are mediated by receptors such as G protein-coupled receptors (GPCRs) and systems including endoplasmic reticulum stress (ER stress).
Rohit Gundamaraju, Wenying Lu, Iman Azimi, Rajaraman Eri, Sukhwinder Singh Sohal   +4 more
doaj   +1 more source

Therapeutic Effects of Natural Compounds and Small Molecule Inhibitors Targeting Endoplasmic Reticulum Stress in Alzheimer’s Disease

Frontiers in Cell and Developmental Biology, 2021
Alzheimer’s disease (AD) is the most common neurodegenerative disease, characterized by progressive cognitive impairment and memory loss. So far, the pathogenesis of AD has not been fully understood.
Xun Gao, Yuanyuan Xu
doaj   +1 more source

Induction of Endoplasmic Reticulum Stress by CdhM Mediates Apoptosis of Macrophage During Mycobacterium tuberculosis Infection

Frontiers in Cellular and Infection Microbiology, 2022
The normal operation of the endoplasmic reticulum (ER) is critical for cells and organisms. However, ER stress, caused by imbalanced protein folding, occurs frequently, which perturbs the function of the ER and even results in cell apoptosis eventually ...
Peng Xu, Jing Tang, Zheng-Guo He
doaj   +1 more source

Cell Death Signaling From Endoplasmic Reticulum Stress: Plant-Specific and Conserved Features

Frontiers in Plant Science, 2022
The endoplasmic reticulum (ER) stress response is triggered by any condition that disrupts protein folding and promotes the accumulation of unfolded proteins in the lumen of the organelle.
Eduardo B. Simoni, Célio C. Oliveira, Otto T. Fraga, Pedro A. B. Reis, Elizabeth P. B. Fontes   +4 more
doaj   +1 more source

Lipopolysaccharide, high glucose and saturated fatty acids induce endoplasmic reticulum stress in cultured primary human adipocytes : salicylate alleviates this stress [PDF]

, 2010
Recent findings indicate that endoplasmic reticulum (ER) stress is significantly increased in adipose tissue of obese human subjects and is critical to the initiation and integration of pathways of inflammation and insulin action.
Saif Alhusaini, Harte, A., McGee, K., Gyanendra Tripathi, Kumar, Sudhesh, Tripathi, Gyanendra, Sudhesh Kumar, Alhusaini, S., McTernan, P. G., Harte, A. L., McTernan, P., Bruno Schisano, Philip McTernan, Schisano, B., McGee, K. C., Kumar, S., Alison Harte, Tripathi, G., Kirsty McGee   +18 more
core   +1 more source

Androgens impair β-cell function in a mouse model of polycystic ovary syndrome by activating endoplasmic reticulum stress

Endocrine Connections, 2021
Background: Androgens excess results in endoplasmic reticulum (ER) stress, which is an important cause of β cells dysfunction. Here, we investigated the molecular regulation of androgens excess, ER stress, and β-cell function in polycystic ovary syndrome
Bo Zhu, Yumei Chen, Fang Xu, Xiaolu Shen, Xuanyu Chen, Jieqiang Lv, Songying Zhang   +6 more
doaj   +1 more source

Dexmedetomidine Alleviated Endoplasmic Reticulum Stress via Inducing ER-phagy in the Spinal Cord of Neuropathic Pain Model

Frontiers in Neuroscience, 2020
Studies demonstrated that spinal autophagy was impaired in spinal nerve ligation (SNL) rats. However, the relationship of endoplasmic reticulum (ER) stress and ER-phagy and whether dexmedetomidine (DEX) modulates ER-phagy remain unclear.
Yongda Liu, Yongda Liu, Shuang Wang, Zhibin Wang, Zhibin Wang, Mengmeng Ding, Mengmeng Ding, Xingyue Li, Xingyue Li, Jiao Guo, Jiao Guo, Guang Han, Guang Han, Ping Zhao, Ping Zhao   +14 more
doaj   +1 more source

ERK1/2 signalling protects against apoptosis following endoplasmic reticulum stress but cannot provide long-term protection against BAX/BAK-independent cell death. [PDF]

PLoS ONE, 2017
Disruption of protein folding in the endoplasmic reticulum (ER) causes ER stress. Activation of the unfolded protein response (UPR) acts to restore protein homeostasis or, if ER stress is severe or persistent, drive apoptosis, which is thought to proceed
Nicola J Darling, Kathryn Balmanno, Simon J Cook   +2 more
doaj   +1 more source

Endoplasmic Reticulum Stress and Reactive Oxygen Species in Plants

Antioxidants, 2022
The endoplasmic reticulum (ER) is a key compartment responsible for protein processing and folding, and it also participates in many signal transduction and metabolic processes. Reactive oxygen species (ROS) are important signaling messengers involved in
Jiajian Cao, Chunhua Wang, Ning Hao, Toru Fujiwara, Tao Wu   +4 more
doaj   +1 more source