Results 11 to 20 of about 225,463 (263)
Current Status of Endoplasmic Reticulum Stress in Type II Diabetes
Molecules, 2021 The endoplasmic reticulum (ER) plays a multifunctional role in lipid biosynthesis, calcium storage, protein folding, and processing. Thus, maintaining ER homeostasis is essential for cellular functions.
Sagir Mustapha +13 more
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Animal Cells and Systems, 2023 Autophagy plays a critical role in regulating the quality and quantity of cellular compartments; however, the mechanisms governing endoplasmic reticulum (ER) autophagy (ER-phagy) are still largely undefined.
Joon Bum Kim +9 more
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Diversification and deleterious role of microbiome in gastric cancer
Cancer Reports, 2023 Gut microbiota dictates the fate of several diseases, including cancer. Most gastric cancers (GC) belong to gastric adenocarcinomas (GAC). Helicobacter pylori colonizes the gastric epithelium and is the causative agent of 75% of all stomach malignancies ...
Indranil Chattopadhyay +2 more
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Endogenous Anti-Cancer Candidates in GPCR, ER Stress, and EMT
Biomedicines, 2020 The majority of cellular responses to external stimuli are mediated by receptors such as G protein-coupled receptors (GPCRs) and systems including endoplasmic reticulum stress (ER stress).
Rohit Gundamaraju +4 more
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Frontiers in Cell and Developmental Biology, 2021 Alzheimer’s disease (AD) is the most common neurodegenerative disease, characterized by progressive cognitive impairment and memory loss. So far, the pathogenesis of AD has not been fully understood.
Xun Gao, Yuanyuan Xu
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Frontiers in Cellular and Infection Microbiology, 2022 The normal operation of the endoplasmic reticulum (ER) is critical for cells and organisms. However, ER stress, caused by imbalanced protein folding, occurs frequently, which perturbs the function of the ER and even results in cell apoptosis eventually ...
Peng Xu, Jing Tang, Zheng-Guo He
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Getting the better of ER stress [PDF]
Journal of Cell Communication and Signaling, 2014 Research over the past few years has highlighted the ability of the unfolded protein response (UPR) to minimize the deleterious effects of accumulated misfolded proteins under both physiological and pathological conditions. The endoplasmic reticulum (ER) adapts to endogenous and exogenous stressors by expanding its protein-folding capacity and by ...
Mollereau, Bertrand +2 more
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Cell Death Signaling From Endoplasmic Reticulum Stress: Plant-Specific and Conserved Features
Frontiers in Plant Science, 2022 The endoplasmic reticulum (ER) stress response is triggered by any condition that disrupts protein folding and promotes the accumulation of unfolded proteins in the lumen of the organelle.
Eduardo B. Simoni +4 more
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ER stress and neurodegenerative diseases [PDF]
Cell Death & Differentiation, 2006 Endoplasmic reticulum (ER) stress is caused by disturbances in the structure and function of the ER with the accumulation of misfolded proteins and alterations in the calcium homeostasis. The ER response is characterized by changes in specific proteins, causing translational attenuation, induction of ER chaperones and degradation of misfolded proteins.
D, Lindholm, H, Wootz, L, Korhonen
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Endocrine Connections, 2021 Background: Androgens excess results in endoplasmic reticulum (ER) stress, which is an important cause of β cells dysfunction. Here, we investigated the molecular regulation of androgens excess, ER stress, and β-cell function in polycystic ovary syndrome
Bo Zhu +6 more
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