Results 61 to 70 of about 59,057 (299)

Copper A Novel Regulator Of Perk

, 2022
PERK is a transmembrane kinase located on the ER with a luminal domain that senses ER stresses, such as protein misfolding, and a cytosolic kinase domain.
Bond, Sarah Elizabeth
core  

Enzymatic Characterization of ER Stress-Dependent Kinase, PERK, and Development of a High-Throughput Assay for Identification of PERK Inhibitors [PDF]

, 2015
PERK is serine/threonine kinase localized to the endoplasmic reticulum (ER) membrane. PERK is activated and contributes to cell survival in response to a variety of physiological stresses that affect protein quality control in the ER, such as hypoxia ...
Pytel, Dariusz, Concannon, John B., Ray, Soumya S., Cuny, Gregory D., Seyb, Kathleen I., Huang, Mickey M., Glicksman, Marcie A., Liu, Min, Diehl, J.A.   +8 more
core   +1 more source

Bi-allelic Perk deletion abolishes Braf^V600ECA/+;Fbxo4+/- melanoma initiation, but Perk inhibition cannot recede tumor progression.

, 2017
A) Kaplan-Mayer survival curve of BrafV600ECA/+, Fbxo4 +/- and Perk +/+, +/- or -/- mice treated with 4-Hydroxytamoxifen (4-HT). B) Western blot of melanoma lysates from TyrCreCA/+; BrafV600ECA/+; Fbxo4 +/-; Perk +/+, Perk+/- or Perk-/- mice C) IHC ...
Yan Gao (93649), Serge Y. Fuchs (217962), Ireneusz Majsterek (3558608), Meenhard Herlyn (291309), Olga S. Chajewski (3558605), Akihiro Yoshida (713605), Dariusz Pytel (3558602), Maria C. G. Paredes (3558617), Kirk A. Staschke (569568), Yuliya V. Katlinskaya (3558614), J. Alan Diehl (3109995), Katarzyna Mackiewicz (362448), Shuo Qie (3110010), Gao Zhang (660886), Lawrence Wu (3558611)   +14 more
core   +1 more source

Engineered Brain‐Targeted Exosomes Delivering FGF1 for Sustained Glycemic Regulation and Multitarget Neurovascular Protection in Diabetic Stroke

Advanced Science, EarlyView.
ABSTRACT Diabetic stroke is characterized by a hyperglycemic and pro‐inflammatory microenvironment that exacerbates neurovascular dysfunction. However, the blood–brain barrier (BBB) remains a formidable obstacle, restricting the delivery of most therapeutic molecules.
Bixin Shen, Chengxiang Zhang, Junhui Wang, Xichong Zhong, Shihao Chen, Xue Wang, Xiaokun Li, Li Lin   +7 more
wiley   +1 more source

High glucose causes apoptosis of rabbit corneal epithelial cells involving activation of PERK-eIF2α-CHOP-caspase-12 signaling pathway [PDF]

International Journal of Ophthalmology, 2019
AIM: To investigate the effect of high concentration of glucose (HCG) on double stranded RNA-activated protein kinase-like ER kinase (PERK)-eukaryotic initiation factor-2α (eIF2α)-transcription factor C/EBP homologous protein (CHOP)-cysteine aspartate ...
Pan-Pan Yao, Min-Jie Sheng, Wen-Hao Weng, Yin Long, Hao Liu, Li Chen, Jia-Jun Lu, Ao Rong, Bing Li   +8 more
doaj   +1 more source

Chemical Bond‐Orchestrated Energy Depletion to Augment Lung Cancer Chemo‐Immunotherapy

Advanced Science, EarlyView.
This study grafted dichloroacetic acid (DCA) into perylenediimide (PDI) skeleton via ionic or covalent bond to create novel metabolic agent PDIC‐AC and PDIC‐NAC, explicitly elaborated the underlying energy metabolism and therapeutic mechanism, and developed a promising strategy for energy metabolism‐targeting chemo‐immunotherapy by chemical bond ...
Xuejie Zhao, Yuting Liu, Xiao Huang, Liwen Zhao, Chunli Li, Yongwei Huang   +5 more
wiley   +1 more source

CDK4/MERCs/PINK1 Axis Drives PFOA/HFPO‐TA‐Induced Cardiac Senescence via Mitophagy Defect and cGAS‐STING Activation: In Vitro Amelioration by Cycloastragenol

Advanced Science, EarlyView.
The present study demonstrated that PFOA and HFPO‐TA exposure suppressed CDK4, disrupted MERCs and impaired PINK1/Parkin‐mediated mitophagy, thereby accelerating cardiac senescence, whereas CAG effectively reversed these pathological changes in vitro. Our findings identify CDK4 as a critical regulator bridging mitophagy defects and cardiac senescence ...
Nuo‐Wa Li, Jun‐Ze Jiang, Ying‐Ying Liu, Tian‐Tian Zhang, Kanwar Kumar Malhi, Xin Yao, Jin‐Long Li   +6 more
wiley   +1 more source

Hypoxia-Activated PERK Promotes Epithelial-Mesenchymal Transition in Gliomas: A Single-Cell and Spatial Transcriptomic Study With Therapeutic Implications

Frontiers in Bioscience-Landmark
Background: Glioma, the most common brain tumor in adults, exhibits marked hypoxia and invasiveness. Endoplasmic reticulum stress (ERS) and the unfolded protein response (UPR) have been implicated in tumor progression, while epithelial
Jingyan Gu, Yue Kong, Yaohua Liu, Xu Wang, Hongyu Tang, Tingting Zang, Jian Yin, Lianping Gu   +7 more
doaj   +1 more source

Identification and characterization of PERK activators by phenotypic screening and their effects on NRF2 activation.

PLoS ONE, 2015
Endoplasmic reticulum stress plays a critical role to restore the homeostasis of protein production in eukaryotic cells. This vital process is hence involved in many types of diseases including COPD.
Wensheng Xie, Marie Pariollaud, William E Wixted, Nilesh Chitnis, James Fornwald, Maggie Truong, Christina Pao, Yan Liu, Robert S Ames, James Callahan, Roberto Solari, Yolanda Sanchez, Alan Diehl, Hu Li   +13 more
doaj   +1 more source

Brain-Specific Disruption of the eIF2α Kinase PERK Decreases ATF4 Expression and Impairs Behavioral Flexibility

Cell Reports, 2012
Translational control depends on phosphorylation of eIF2α by PKR-like ER kinase (PERK). To examine the role of PERK in cognitive function, we selectively disrupted PERK expression in the adult mouse forebrain.
Mimi A. Trinh, Hanoch Kaphzan, Ronald C. Wek, Philippe Pierre, Douglas R. Cavener, Eric Klann   +5 more
doaj   +1 more source