Results 81 to 90 of about 59,057 (299)
Characterization of a tumor-derived mutation of the PERK kinase.
, 2017 A) Depection of melanoma-derived PERK mutations. B-D) Western analysis of MEF lysates expressing murine versions of Perk alleles tested under ER-stress conditions.
Yan Gao (93649) +14 more
core +1 more source
Divergent effects of PERK and IRE1 signaling on cell viability. [PDF]
, 2009 Protein misfolding in the endoplasmic reticulum (ER) activates a set of intracellular signaling pathways, collectively termed the Unfolded Protein Response (UPR). UPR signaling promotes cell survival by reducing misfolded protein levels.
Lin Jonathan H. +14 more
core +1 more source
Business Strategy and the Environment, EarlyView.ABSTRACT The socio‐emotional wealth (SEW) perspective suggests that the specific priorities of a family business may make it more or less inclined to engage in sustainable practices. This paper examines how family business heterogeneity regarding family ownership, financial performance, and family board members affects the sustainability commitment of ...
Sonia Sánchez‐Andújar +2 more
wiley +1 more source
Modulation Of PERK Signalling During Neurodegeneration
, 2019 Numerous neurodegenerative diseases are characterised by the aggregation of misfolded disease-specific proteins in the brain. This is often associated with increased activation of the unfolded protein response (UPR), particularly the PKR-like Endoplasmic
Daniel T. Hughes (7785638)
core
Hypoxia‐Activated Prodrugs of PERK Inhibitors
, 2019 Tumour hypoxia plays an important role in tumour progression and resistance to therapy. Under hypoxia unfolded proteins accumulate in the endoplasmic reticulum (ER) and this stress is relieved through the protein kinase R‐like ER kinase (PERK) signalling
Michael P. Hay +11 more
core +1 more source
Business Strategy and the Environment, EarlyView.ABSTRACT Corporate environmental communication has become an essential aspect of modern business practices, as stakeholders increasingly demand transparency and accountability regarding sustainability efforts. Within this context, we examine whether firms use environmental communication on X/Twitter to offset weaker relative environmental performance ...
Ivan Russo +3 more
wiley +1 more source
Secretopathies emerge as a new class of neurocristopathies
Developmental Dynamics, EarlyView.Abstract Neural crest cells are a transient embryonic population of cells that give rise to a wide range of structures, including craniofacial cartilage and bone, peripheral neurons and glia, as well as components of the cardiac outflow tract, among others.
Amanda Teixeira +3 more
wiley +1 more source
ER stress tolerance is regulated by copper-dependent PERK kinase activity
Cell ReportsSummary: Pancreatic/PKR-like endoplasmic reticulum (ER) kinase (PERK) is a kinase that, in response to ER stress, mediates dual homeostatic and pro-apoptotic signaling. Thus, intricate regulation is required for physiological function.
Sarah E. Bond Newton +9 more
doaj +1 more source
Complex V knockdown activates the Integrated Stress Response through PERK.
, 2023 (a) Schematic of Drosophila eIF2α kinases. Amino acid deprivation or endoplasmic reticulum (ER) stress activate either GCN2 or PERK, respectively. Both kinases dimerize and phosphorylate eIF2α.
Vernon Leander Monteiro (14504887) +3 more
core +1 more source
Developmental Dynamics, EarlyView.Abstract Background Fibrillins provide a scaffold for elastic fiber formation, which enables lung recoil and aortic compliance. Abnormal fibrillin microfibrils, as in Marfan syndrome, lead to enlarged alveoli, vascular stiffening, and aneurysms. Our earlier studies suggested that fibrillin function depends on O‐glucosylation of its epidermal growth ...
Sanjiv Neupane +4 more
wiley +1 more source