Results 71 to 80 of about 59,057 (299)

The Antidiabetic Potential of Alpha‐Mangostin: A Review of Preclinical and Clinical Evidence

AgriFood: Journal of Agricultural Products for Food, EarlyView.
Alpha‐mangostin is a compound from the pericarp of Garcinia mangostana. The antidiabetic effects of alpha‐mangostin include enhancing insulin secretion, improving glucose uptake through GLUT receptor upregulation, reducing oxidative stress and inflammation, promoting wound healing, reducing HbA1C, reducing HOMA‐IR index, and decreased mRNA expressions ...
Oliver Dean John, Nur Damia Iwani Zulkiflee, Siti Raihanah Shafie, Ramlah George, Melonney Patrick   +4 more
wiley   +1 more source

Owning Home, Finding Belonging: Relational Meanings of Homeownership for Migrant Healthcare Workers in Australia

Australian Journal of Social Issues, EarlyView.
ABSTRACT Migrant healthcare workers in Australia find themselves at the centre of three intersecting concerns, often presented as ‘crises’ in contemporary discourse: the ‘care crisis’, the ‘housing crisis’ and the ‘migration crisis.’ Yet their own perspectives on these issues are rarely foregrounded. This paper explores the role of homeownership in the
Leah Williams Veazey
wiley   +1 more source

Genetic knock-in of EIF2AK3 variants reveals differences in PERK activity in mouse liver and pancreas under endoplasmic reticulum stress

Scientific Reports
Common single-nucleotide variants (SNVs) of eukaryotic translation initiation factor 2 alpha kinase 3 (EIF2AK3) slightly increase the risk of disorders in the periphery and the central nervous system.
Shivesh Ghura, Noah R. Beratan, Xinglong Shi, Elena Alvarez-Periel, Sarah E. Bond Newton, Cagla Akay-Espinoza, Kelly L. Jordan-Sciutto   +6 more
doaj   +1 more source

Activation of the PERK/eIF2α axis is a pivotal prerequisite of taxanes to cancer cell apoptosis and renders synergism to overcome paclitaxel resistance in breast cancer cells

Cancer Cell International
Background Microtubule polymerization is usually considered as the upstream of apoptotic cell death induced by taxanes, but recently published studies provide more insights into the mechanisms responsible for the antineoplastic effect of taxanes. In this
Wanhua Cai, Dade Rong, Jiayu Ding, Xiaomei Zhang, Yuwei Wang, Ying Fang, Jing Xiao, Shulan Yang, Haihe Wang   +8 more
doaj   +1 more source

Endoplasmic reticulum stress-independent activation of unfolded protein response kinases by a small molecule ATP-mimic

eLife, 2015
Two ER membrane-resident transmembrane kinases, IRE1 and PERK, function as stress sensors in the unfolded protein response. IRE1 also has an endoribonuclease activity, which initiates a non-conventional mRNA splicing reaction, while PERK phosphorylates ...
Aaron S Mendez, Jennifer Alfaro, Marisol A Morales-Soto, Arvin C Dar, Emma McCullagh, Katja Gotthardt, Han Li, Diego Acosta-Alvear, Carmela Sidrauski, Alexei V Korennykh, Sebastian Bernales, Kevan M Shokat, Peter Walter   +12 more
doaj   +1 more source

Mscr.Dresd.App.2534,1-4603, Mscr.Dresd.App.2534.a,1-537 - Spezialkatalog zu den Nachlässen von Ernst Hassebrauk und Charlotte Hassebrauk [PDF]

, 2020
Zusammengestellt von Perk Loesch und Kerstin Schellbach in den Jahren 1990 und ...
Loesch, Perk, Schellbach, Kerstin
core   +2 more sources

Insulin production was modulated by Perk during development.

, 2014
A. Total pancreatic insulin content of Perk+/− mice relative to Perk+/+ during postnatal development. Shown are means ± SEM (n for Perk +/−, Perk+/+  =  14, 16 (P5); 8,5 (P17); 18, 16 (P30); 10, 15 (P50); 8, 6 (P180 ...
Elyse E. Munoz (575799), Barbara C. McGrath (210345), Douglas R. Cavener (210348), Rong Wang (59795), Siying Zhu (459098)   +4 more
core   +1 more source

Recent Advances in Virus–Host Interactions, Antiviral Bioactive Compounds, and Breeding for Disease Resistance of Porcine Epidemic Diarrhea Virus

Animal Research and One Health, EarlyView.
Basic research on the PEDV infection cycle and virus–host interactions advances the development of anti‐PEDV drugs and disease‐resistant breeding and helps strengthen disease prevention and control while reducing economic losses in the swine industry.
Heyong Wu, Aosi Qi, Shuyu Zhong, Haozhen Du, Shimeng Guo, Hongsheng Ouyang, Hongming Yuan, Daxin Pang, Zicong Xie   +8 more
wiley   +1 more source

Indole‐3‐Acetic Acid Protects Bovine Hepatocytes Against Palmitic Acid‐Induced Lipid Accumulation and ER Stress Through SIRT3

Animal Research and One Health, EarlyView.
Cows with ketosis during the perinatal period often experience damage to the liver, a core metabolic organ, thereby exacerbating the disease's inherent vicious cycle. This study indicates that serum 3‐IAA concentrations were reduced in ketotic cows and show a significant negative correlation with hepatic TG content.
Dandan Qi, Chenchen Zhao, Guiying Li, Jinxia Li, Menglin Liu, Fanrong Kong, Enzhu Li, Jie Gao, Wenqi Liao, Akos Kenez, Wenwen Gao, Yuxiang Song, Xiliang Du, Guowen Liu, Xinwei Li, Lin Lei   +15 more
wiley   +1 more source

Dual leucine zipper kinase-dependent PERK activation contributes to neuronal degeneration following insult

eLife, 2017
The PKR-like endoplasmic reticulum kinase (PERK) arm of the Integrated Stress Response (ISR) is implicated in neurodegenerative disease, although the regulators and consequences of PERK activation following neuronal injury are poorly understood.
Martin Larhammar, Sarah Huntwork-Rodriguez, Zhiyu Jiang, Hilda Solanoy, Arundhati Sengupta Ghosh, Bei Wang, Joshua S Kaminker, Kevin Huang, Jeffrey Eastham-Anderson, Michael Siu, Zora Modrusan, Madeline M Farley, Marc Tessier-Lavigne, Joseph W Lewcock, Trent A Watkins   +14 more
doaj   +1 more source