Results 71 to 80 of about 60,696 (203)

PERK-induced transcriptome changes in ISCs.

, 2015
(A, B) Cell sorting strategy to isolate ISCs from intestines expressing YFP in ISCs exclusively under the control of esgts, Su(H)Gbe::Gal80. Cells were gated based on forward and side scatter, YFP fluorescence (A), and cell size (B).
Hyung Don Ryoo (440989), Heinrich Jasper (121327), Yanyan Qi (735569), Lifen Wang (382642)   +3 more
core   +1 more source

Gedichten

, 1898
van Jacques Perk. Met voorrede van Mr. C.
Perk, Jacques
core  

New proinsulin synthesis and mature proinsulin level were up-regulated in P17 Perk^+/− mice.

, 2014
A. Newly synthesized proinsulin in mouse islets measured by western blot. Mice are postnatal 17 days. 10 µg/ml puromycin was added 15 minutes before protein samples were harvested.
Elyse E. Munoz (575799), Barbara C. McGrath (210345), Douglas R. Cavener (210348), Rong Wang (59795), Siying Zhu (459098)   +4 more
core   +1 more source

Pharmacological inhibition of the PERK pathway modulates hepatocellular carcinoma growth and immune signaling

FEBS Open Bio
The unfolded protein response (UPR) plays an important role in tumor progression and cellular stress adaptation. In hepatocellular carcinoma (HCC), pharmacological inhibition of the protein kinase R‐like endoplasmic reticulum kinase (PERK) is a potential
Ada Lerma‐Clavero, Maria Kopsida, Nathalie Arendt, Hans Lennernäs, Markus Sjöblom, Femke Heindryckx   +5 more
doaj   +1 more source

Perks of standards

, 2016
Animation to highlight the perks of ...
Gebhardt, Tom, Peters, Martin
openaire   +1 more source

ER stress sensor PERK promotes T cell pathogenicity in GVHD by regulating ER-associated degradation

The Journal of Clinical Investigation
Endoplasmic reticulum (ER) stress through IRE1/XBP1 is implicated in the onset and progression of graft-versus-host disease (GVHD), but the role of the ER stress sensor PERK in T cell allogeneic responses and GVHD remains unexplored. Here, we report that
Qiao Cheng, Hee-Jin Choi, Yongxia Wu, Xiaohong Yuan, Allison Pugel, Linlu Tian, Michael Hendrix, Denggang Fu, Reza Alimohammadi, Chen Liu, Xue-Zhong Yu   +10 more
doaj   +1 more source

PERK integrates local and tissue-wide ER stress responses to regulate ISC proliferation.

, 2015
(A) Phosphorylation of eIF2α is induced in ISCs/EBs when young intestines are exposed to excessive ER stress. Guts of esg::Gal4, UAS::nlsGFP (nuclear-localized GFP) were immunostained with anti-peIF2α and anti-Armadillo antibodies in either the mock ...
Hyung Don Ryoo (440989), Heinrich Jasper (121327), Yanyan Qi (735569), Lifen Wang (382642)   +3 more
core   +1 more source

Copper A Novel Regulator Of Perk

, 2022
PERK is a transmembrane kinase located on the ER with a luminal domain that senses ER stresses, such as protein misfolding, and a cytosolic kinase domain.
Bond, Sarah Elizabeth
core  

Neuron cells were transfected with RNAi against PERK and control (NT).

, 2013
(A) 16 h later, cells were allowed to recover for 3 days, and LC3II/DNA flowcytometry analyses after indicated period of time. The gate (R2) represented LC3II positive cells in each figure.
Lei Xu (78676), Yongqing Xu (480309), Yanjin Chen (400308), Jing Zhang (23775), Hongpu Sun (480312), Barbara Rossi (480311), Zuozhang Yang (400303), Da Xu (400307), Giulio Maccauro (480310), Yihao Yang (480313), Xuefeng Liu (130787), Hongjun Li (126335)   +11 more
core   +1 more source

Polysulfide and persulfide-mediated activation of the PERK-eIF2α-ATF4 pathway increases Sestrin2 expression and reduces methylglyoxal toxicity

Redox Biology
Unfolded protein response (UPR) is activated in cells under endoplasmic reticulum (ER) stress. One sensor protein involved in this response is PERK, which is activated through its redox-dependent oligomerization.
Shin Koike, Hideo Kimura, Yuki Ogasawara
doaj   +1 more source