Results 51 to 60 of about 60,696 (203)

Preferential binding of TBL2 to phospho-PERK.

, 2014
(A) 293T cells were transiently co-transfected with pTBL2 (V5-tag) and either pFLAG-PERK, pFLAG-PERK(K621A) or pFLAG-IRE1 and then were treated with 300 nM thapsigargin (Tg) for 2 h.
Toru Natsume (659887), Yoshinori Tsukumo (659885), Satomi Tsukahara (659886), Aki Furuno (133003), Shun-ichiro Iemura (46249), Akihiro Tomida (133017)   +5 more
core   +1 more source

Hypoxia-Activated PERK Promotes Epithelial-Mesenchymal Transition in Gliomas: A Single-Cell and Spatial Transcriptomic Study With Therapeutic Implications

Frontiers in Bioscience-Landmark
Background: Glioma, the most common brain tumor in adults, exhibits marked hypoxia and invasiveness. Endoplasmic reticulum stress (ERS) and the unfolded protein response (UPR) have been implicated in tumor progression, while epithelial
Jingyan Gu, Yue Kong, Yaohua Liu, Xu Wang, Hongyu Tang, Tingting Zang, Jian Yin, Lianping Gu   +7 more
doaj   +1 more source

Identification and characterization of PERK activators by phenotypic screening and their effects on NRF2 activation.

PLoS ONE, 2015
Endoplasmic reticulum stress plays a critical role to restore the homeostasis of protein production in eukaryotic cells. This vital process is hence involved in many types of diseases including COPD.
Wensheng Xie, Marie Pariollaud, William E Wixted, Nilesh Chitnis, James Fornwald, Maggie Truong, Christina Pao, Yan Liu, Robert S Ames, James Callahan, Roberto Solari, Yolanda Sanchez, Alan Diehl, Hu Li   +13 more
doaj   +1 more source

Brain-Specific Disruption of the eIF2α Kinase PERK Decreases ATF4 Expression and Impairs Behavioral Flexibility

Cell Reports, 2012
Translational control depends on phosphorylation of eIF2α by PKR-like ER kinase (PERK). To examine the role of PERK in cognitive function, we selectively disrupted PERK expression in the adult mouse forebrain.
Mimi A. Trinh, Hanoch Kaphzan, Ronald C. Wek, Philippe Pierre, Douglas R. Cavener, Eric Klann   +5 more
doaj   +1 more source

PERK mediates oxidative stress and adipogenesis in Graves' orbitopathy pathogenesis

, 2021
We examined endoplasmic reticulum (ER) stress-related gene expression in orbital tissues from patients with Graves' orbitopathy (GO) and the effects of silencing protein kinase RNA-like endoplasmic reticulum kinase (PERK) in primary orbital fibroblast ...
이은직, 고재상, 윤진숙, Eun Jig Lee, Jin Sook Yoon, JaeSang Ko, Ji-Young Kim, Min Kyung Chae   +7 more
core   +1 more source

Mono-allelic Perk deletion reduces pro-apoptotic signals and maintains pro-survival signaling.

, 2017
H&E and IHC of premalignant skin from TyrCreCA/+;BrafV600ECA/+, Perk +/+ or Perk+/- and Perk-/- mice for the indicated targets and quantification of staining/staining index (SI) of IHC; scale bars = 50μm.
Yan Gao (93649), Serge Y. Fuchs (217962), Ireneusz Majsterek (3558608), Meenhard Herlyn (291309), Olga S. Chajewski (3558605), Akihiro Yoshida (713605), Dariusz Pytel (3558602), Maria C. G. Paredes (3558617), Kirk A. Staschke (569568), Yuliya V. Katlinskaya (3558614), J. Alan Diehl (3109995), Katarzyna Mackiewicz (362448), Shuo Qie (3110010), Gao Zhang (660886), Lawrence Wu (3558611)   +14 more
core   +1 more source

Activation of the PERK/eIF2α axis is a pivotal prerequisite of taxanes to cancer cell apoptosis and renders synergism to overcome paclitaxel resistance in breast cancer cells

Cancer Cell International
Background Microtubule polymerization is usually considered as the upstream of apoptotic cell death induced by taxanes, but recently published studies provide more insights into the mechanisms responsible for the antineoplastic effect of taxanes. In this
Wanhua Cai, Dade Rong, Jiayu Ding, Xiaomei Zhang, Yuwei Wang, Ying Fang, Jing Xiao, Shulan Yang, Haihe Wang   +8 more
doaj   +1 more source

Endoplasmic reticulum stress-independent activation of unfolded protein response kinases by a small molecule ATP-mimic

eLife, 2015
Two ER membrane-resident transmembrane kinases, IRE1 and PERK, function as stress sensors in the unfolded protein response. IRE1 also has an endoribonuclease activity, which initiates a non-conventional mRNA splicing reaction, while PERK phosphorylates ...
Aaron S Mendez, Jennifer Alfaro, Marisol A Morales-Soto, Arvin C Dar, Emma McCullagh, Katja Gotthardt, Han Li, Diego Acosta-Alvear, Carmela Sidrauski, Alexei V Korennykh, Sebastian Bernales, Kevan M Shokat, Peter Walter   +12 more
doaj   +1 more source

pERK score in urothelial tumors.

, 2021
(A) Representative photographs of pERK immunohistochemistry (original magnification 400×) from each category are shown. (B) pERK staining intensity was evaluated and scored (0–5), and pERK score in each category was shown (N: non-tumor; n = 101, P ...
Li Chunning (11752069), Shinsuke Oda (11752066), Teizo Yoshimura (199118), Akihiro Matsukawa (197990), Takahiro Yamaguchi (602945), Masayoshi Fujisawa (5844029), Toshihiro Ito (197968)   +6 more
core   +1 more source

Dual leucine zipper kinase-dependent PERK activation contributes to neuronal degeneration following insult

eLife, 2017
The PKR-like endoplasmic reticulum kinase (PERK) arm of the Integrated Stress Response (ISR) is implicated in neurodegenerative disease, although the regulators and consequences of PERK activation following neuronal injury are poorly understood.
Martin Larhammar, Sarah Huntwork-Rodriguez, Zhiyu Jiang, Hilda Solanoy, Arundhati Sengupta Ghosh, Bei Wang, Joshua S Kaminker, Kevin Huang, Jeffrey Eastham-Anderson, Michael Siu, Zora Modrusan, Madeline M Farley, Marc Tessier-Lavigne, Joseph W Lewcock, Trent A Watkins   +14 more
doaj   +1 more source