Results 71 to 80 of about 1,143,124 (339)

Modulation of Homer1 EVH1 domain internal dynamics by putative autism‐associated mutations

FEBS Letters, EarlyView.
The putative autism‐associated M65I and S97L variants of the EVH1 domain of the postsynaptic scaffold protein Homer1 do not exhibit substantial changes in their overall structure or partner binding. Both of them, but especially the M65I variant, show altered internal dynamics relative to the wild‐type domain on the μs‐ms timescale, indicated by the ...
Fanni Farkas, Brigitta Maruzs, Zsófia E. Kálmán, Tomas Klumpler, Gyula Batta, Bálint Péterfia, Zoltán Gáspári   +6 more
wiley   +1 more source

Regulation of Endoplasmic Reticulum Stress-Autophagy: A Potential Therapeutic Target for Ulcerative Colitis

Frontiers in Pharmacology, 2021
Ulcerative colitis (UC) is a chronic nonspecific inflammation that mainly affects the mucosa and submucosa of the rectum and colon. Numerous studies have shown that endoplasmic reticulum stress (ERS)-induced autophagy plays a vital role in the ...
Dan Qiao, Ziwei Zhang, Yali Zhang, Qian Chen, Yujun Chen, Yingjue Tang, Xiong Sun, Zhipeng Tang, Yancheng Dai   +8 more
doaj   +1 more source

Molecular mechanism of ATF6 in unfolded protein response and its role in disease

Heliyon
Activating transcription factor 6 (ATF6), an important signaling molecule in unfolded protein response (UPR), plays a role in the pathogenesis of several diseases, including diseases such as congenital retinal disease, liver fibrosis and ankylosing ...
Yingying Lei, Hong-Bin Yu, Shaoxue Ding, Hui Liu, Chunyan Liu, Rong Fu   +5 more
semanticscholar   +1 more source

Regulated increase in folding capacity prevents unfolded protein stress in the ER

, 2010
Stimulation of thyrocytes with thyroid stimulating hormone (TSH) leads to a morphological change and a massive increase in thyroglobulin (Tg) production.
Mkrtchian, S., Schildknegt, D., Fullaondo, A., Sub Cellular Protein Chemistry, Heck, A.J.R., Braakman, L.J., Christis, C., Cellular Protein Chemistry, Dep Scheikunde, Sub Biomol.Mass Spectrometry & Proteom., Biomolecular Mass Spectrometry and Proteomics, Sub Biomol.Mass Spect. and Proteomics   +11 more
core   +1 more source

The unfolded protein response in Alzheimer’s disease

Seminars in Immunopathology, 2013
Alzheimer's disease (AD) is a progressive neurodegenerative disorder characterized by synaptic dysfunction and accumulation of amyloid-beta (Aβ) peptide, which are responsible for the progressive loss of memory. The mechanisms involved in neuron dysfunction in AD remain poorly understood.
Cornejo, Víctor Hugo, Hetz Flores, Claudio   +1 more
openaire   +8 more sources

The ubiquitin‐proteasome system and autophagy as guardians of the cellular proteome

FEBS Letters, EarlyView.
This Perspective covers the three principles governing the crosstalk between the ubiquitin‐proteasome system and autophagy in cellular proteostasis: (1) a shared ubiquitin code routing substrates via shuttle factors or autophagy receptors; (2) spatial compartmentalization into phase‐separated degradation hubs and organelle‐specific modules (exemplified
Ivan Dikic
wiley   +1 more source

The fail-safe mechanism of post-transcriptional silencing of unspliced HAC1 mRNA

eLife, 2016
HAC1 encodes a transcription factor that is the central effector of the unfolded protein response (UPR) in budding yeast. When the UPR is inactive, HAC1 mRNA is stored as an unspliced isoform in the cytoplasm and no Hac1 protein is detectable.
Rachael Di Santo, Soufiane Aboulhouda, David E Weinberg   +2 more
doaj   +1 more source

Avaliação da ativação da via UPR e do perfil de citocinas séricas em indivíduos HIV soropositivos [PDF]

, 2012
TCC(graduação) - Universidade Federal de Santa Catarina. Centro de Ciências Biológicas. Biologia.A via UPR (do inglês Unfolded Protein Response) é uma resposta celular ao estresse causado pelo acúmulo de proteínas desenoveladas no retículo endoplasmático.
Tonello, Yuri Tonello
core  

Activation of the unfolded protein response is associated with favorable prognosis in acute myeloid leukemia

, 2009
PURPOSE: The unfolded protein response is triggered by the accumulation of misfolded proteins within the endoplasmic reticulum. Previous studies suggest that the unfolded protein response is activated in some cancer cell lines and involved in tumor ...
M. Eyholzer, B. U. Mueller, Pabst, Thomas, Schardt, Julian A, Mueller, Beatrice U, J. A. Schardt, Weber, Daniel, D. Weber, Eyholzer, Marianne, T. Pabst   +9 more
core   +1 more source

When is the unfolded protein response not the unfolded protein response?

Plant Science, 2017
As sessile organisms, plants are subjected to variety of stresses for which they have evolved different protection mechanisms. One mechanism involves endoplasmic reticulum (ER) stress in which the process of protein folding is disturbed and misfolded proteins accumulate in the ER. ER stress elicits the unfolded protein response (UPR) whereby the stress
openaire   +2 more sources