Results 31 to 40 of about 1,143,124 (339)

Unfolded Protein Corona Surrounding Nanotubes Influence the Innate and Adaptive Immune System

Advanced Science, 2021
The plasma proteins around nanoparticles (NPs) form an outer protein corona, significantly influencing the subsequent immune response. However, it was uncertain whether the protein corona around NPs influences immune response.
Jun‐Young Park, Sung Jean Park, Jun Young Park, Sang‐Hyun Kim, Song Kwon, YunJae Jung, Dongwoo Khang   +6 more
doaj   +1 more source

Endoplasmic Reticulum Stress and Unfolded Protein Response Signaling in Plants

International Journal of Molecular Sciences, 2022
Plants are sensitive to a variety of stresses that cause various diseases throughout their life cycle. However, they have the ability to cope with these stresses using different defense mechanisms.
Hakim Manghwar, Jianming Li
semanticscholar   +1 more source

Regulation of lipid metabolism by the unfolded protein response

Journal of Cellular and Molecular Medicine, 2021
The endoplasmic reticulum (ER) is the site of protein folding and secretion, Ca2+ storage and lipid synthesis in eukaryotic cells. Disruption to protein folding or Ca2+ homeostasis in the ER leads to the accumulation of unfolded proteins, a condition ...
Matthieu Moncan, K. Mnich, A. Blomme, Aitor Almanza, Afshin Samali, A. Gorman   +5 more
semanticscholar   +1 more source

Activation of mitochondrial unfolded protein response protects against multiple exogenous stressors

Life Science Alliance, 2021
This work highlights the importance of the mitochondrial unfolded protein response in allowing organisms to survive external stressors through up-regulation of other stress response pathways.
Sonja K Soo, Annika Traa, Paige D Rudich, Meeta Mistry, Jeremy M Van Raamsdonk   +4 more
doaj   +1 more source

Herpesviruses and the Unfolded Protein Response [PDF]

Viruses, 2019
Herpesviruses usurp cellular stress responses to promote viral replication and avoid immune surveillance. The unfolded protein response (UPR) is a conserved stress response that is activated when the protein load in the ER exceeds folding capacity and misfolded proteins accumulate.
Benjamin P. Johnston, Craig McCormick
openaire   +2 more sources

Manipulation of the unfolded protein response: A pharmacological strategy against coronavirus infection

PLoS Pathogens, 2021
Coronavirus infection induces the unfolded protein response (UPR), a cellular signalling pathway composed of three branches, triggered by unfolded proteins in the endoplasmic reticulum (ER) due to high ER load.
Liliana Echavarría-Consuegra, Georgia M. Cook, I. Busnadiego, Charlotte Lefèvre, S. Keep, Katherine Brown, Nicole Doyle, G. Dowgier, Krzysztof Franaszek, Nathan A Moore, S. Siddell, Erica Bickerton, B. G. Hale, A. Firth, I. Brierley, N. Irigoyen   +15 more
semanticscholar   +1 more source

Consensus clustering and functional interpretation of gene-expression data [PDF]

, 2004
Microarray analysis using clustering algorithms can suffer from lack of inter-method consistency in assigning related gene-expression profiles to clusters.
Liu, X, Orengo, Christine, Martin, N, Kellam, P., Paul Kellam, Liu, X., Swift, Stephen, Swift, S, Orengo, C.A., Tucker, Allan, Tucker, A., Tucker, A, Liu, XH, Allan Tucker, Vinciotti, Veronica, Christine Orengo, Veronica Vinciotti, Vinciotti, V., Xiaohui Liu, Swift, S., Kellam, P, Liu, Xiaohui, Vinciotti, V, Stephen Swift, Kellam, Paul, Orengo, C, Martin, Nigel, Nigel Martin   +27 more
core   +1 more source

The unfolded protein response and the biology of uveal melanoma

, 2022
Uveal melanoma (UM) is a highly metastatic ocular cancer that arises from the melanocytes of the uveal tract (the choroid, ciliary body and iris). Despite a growing understanding of UM biology, effective systemic treatments are currently lacking and the ...
Conway, R Max, Wang, Ke, Zhu, Xue, Murray, Michael, Cherepanoff, Svetlana, Zhou, Fanfan, Zhang, Stanley, Madigan, Michele C, Zhu, Ling   +8 more
core   +1 more source

Unfolded Protein Responses With or Without Unfolded Proteins? [PDF]

Cells, 2012
The endoplasmic reticulum (ER) is the site of secretory protein biogenesis. The ER quality control (QC) machinery, including chaperones, ensures the correct folding of secretory proteins. Mutant proteins and environmental stresses can overwhelm the available QC machinery.
openaire   +3 more sources

Unfolded Protein Response and Cancer [PDF]

Discoveries, 2014
Physiological stresses, such as hypoxia and oxidative stress, induce protein misfolding in the endoplasmic reticulum (ER). If proteasome degradation fails to remove the misfolded proteins, these proteins accumulate in the ER, triggering the unfolded protein response (UPR).
Wu, Lihua, Chou, Mary, Zhu, Shudong
openaire   +2 more sources