Results 31 to 40 of about 90,832 (259)

StresSeed: The Unfolded Protein Response During Seed Development

Frontiers in Plant Science, 2022
During seed development, the endoplasmic reticulum (ER) takes care of the synthesis and structural maturation of very high amounts of storage proteins in a relatively short time.
Alessandro Vitale, Emanuela Pedrazzini
doaj   +1 more source

Unfolded Protein Response in Arabidopsis [PDF]

, 2017
The unfolded protein response (UPR) is a highly regulated signaling pathway that is largely conserved across eukaryotes. It is essential for cell homeostasis under environmental and physiological conditions that perturb the protein folding in the endoplasmic reticulum (ER).
Cristina, Ruberti, Federica, Brandizzi
openaire   +3 more sources

Response of myeloma to the proteasome inhibitor bortezomib is correlated with the unfolded protein response regulator XBP-1

Haematologica, 2012
Background Multiple myeloma, a malignancy of the antibody-secreting plasma cells, remains incurable by current therapy. However, the proteasome inhibitor bortezomib and other new drugs are revolutionizing its treatment.
Silvia C. W. Ling, Edwin K. K. Lau, Ammira Al-Shabeeb, Angela Nikolic, Albert Catalano, Harry Iland, Noemi Horvath, P. Joy Ho, Simon Harrison, Shaun Fleming, Douglas E. Joshua, John D. Allen   +11 more
doaj   +1 more source

The unfolded protein response in multiple sclerosis

Frontiers in Neuroscience, 2015
The unfolded protein response (UPR) occurs in response to endoplasmic reticulum (ER) stress caused by the accumulation of unfolded or misfolded proteins in the ER.
Wensheng eLin, Sarrabeth eStone
doaj   +1 more source

Fibrillary Glomerulonephritis, DNAJB9, and the Unfolded Protein Response

Glomerular Diseases, 2022
Background: Fibrillary glomerulonephritis (FGN) is found in approximately 1% of native kidney biopsies and was traditionally defined by glomerular deposition of fibrils larger than amyloid (12–24 nm diameter) composed of polyclonal IgG.
Nicole K. Andeen, Vanderlene L. Kung, Josh Robertson, Susan B. Gurley, Rupali S. Avasare, Sneha Sitaraman   +5 more
doaj   +1 more source

The Unfolded Protein Response at the Tumor-Immune Interface

Frontiers in Immunology, 2022
The tumor-immune interface has surged to primary relevance in an effort to understand the hurdles facing immune surveillance and cancer immunotherapy.
Maurizio Zanetti, Su Xian, Magalie Dosset, Hannah Carter   +3 more
doaj   +1 more source

Unfolded Protein Response and Macroautophagy in Alzheimer’s, Parkinson’s and Prion Diseases

Molecules, 2015
Proteostasis are integrated biological pathways within cells that control synthesis, folding, trafficking and degradation of proteins. The absence of cell division makes brain proteostasis susceptible to age-related changes and neurodegeneration. Two key
Irina Milisav, Dušan Šuput, Samo Ribarič   +2 more
doaj   +1 more source

Treatment with the HIV protease inhibitor nelfinavir triggers the unfolded protein response and may overcome proteasome inhibitor resistance of multiple myeloma in combination with bortezomib: a phase I trial (SAKK 65/08)

Haematologica, 2016
Downregulation of the unfolded protein response mediates proteasome inhibitor resistance in multiple myeloma. The Human Immunodeficieny Virus protease inhibitor nelfinavir activates the unfolded protein response in vitro.
Christoph Driessen, Marianne Kraus, Markus Joerger, Hilde Rosing, Jürgen Bader, Felicitas Hitz, Catherine Berset, Alexandros Xyrafas, Hanne Hawle, Gregoire Berthod, Hermann S. Overkleeft, Christiana Sessa, Alwin Huitema, Thomas Pabst, Roger von Moos, Dagmar Hess, Ulrich J.M. Mey   +16 more
doaj   +1 more source

Unfolded Protein Response in Lung Health and Disease

Frontiers in Medicine, 2020
The unfolded protein response (UPR) is a complex element, destined to protect the cells against a diverse variety of extracellular and intracellular challenges. UPR activation devises highly efficient responses to counteract cellular threats.
Nektarios Barabutis
doaj   +1 more source

The role of the unfolded protein response pathway in bone homeostasis and potential therapeutic target in cancer-associated bone disease

Bone Research
The unfolded protein response pathway is an evolutionarily conserved cytoprotective signaling cascade, essential for cell function and survival. Unfolded protein response signaling is tightly integrated with bone cell differentiation and function, and ...
Molly E. Muehlebach, Sarah A. Holstein
doaj   +1 more source