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The unfolded protein response [PDF]
Current Biology, 2005 Where does the UPR function? Between the endoplasmic reticulum (ER) and the nucleus of eukaryotic cells. All secreted proteins and proteins that reside in secretory compartments translocate as nascent peptide chains into the ER, where they may undergo folding, modification and assembly before assuming their functional conformations.
Chawla, Aditi, Niwa, Maho
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Cellular Response to Unfolded Proteins in Depression [PDF]
Life, 2021 Despite many scientific studies on depression, there is no clear conception explaining the causes and mechanisms of depression development. Research conducted in recent years has shown that there is a strong relationship between depression and the endoplasmic reticulum (ER) stress.
Mateusz Kowalczyk +5 more
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The Unfolding Tale of the Unfolded Protein Response [PDF]
Cell, 2001 Surface and secreted proteins are synthesized in the endoplasmic reticulum where they must fold and assemble before being transported. Changes in the ER that interfere with their proper maturation initiate the unfolded protein response pathway. New studies have filled in a missing link between the yeast and mammalian pathways.
Ma, Yanjun, Hendershot, Linda M.
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Unfolded protein response in colorectal cancer
Cell & Bioscience, 2021 Colorectal cancer (CRC) is a gastrointestinal malignancy originating from either the colon or the rectum. A growing number of researches prove that the unfolded protein response (UPR) is closely related to the occurrence and progression of colorectal ...
Jingjing Huang +8 more
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Unpacking the Unfolded Protein Response [PDF]
Cell, 2014 This year, the Albert Lasker Basic Medical Research Award will be shared by Peter Walter and Kazutoshi Mori for discoveries revealing the molecular mechanism of the unfolded protein response, an intracellular quality control system that detects harmful misfolded proteins in the endoplasmic reticulum and then signals the nucleus to carry out corrective ...
Worby, Carolyn A., Dixon, Jack E.
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The Unfolded Protein Response and Diabetic Retinopathy [PDF]
Journal of Diabetes Research, 2014 Diabetic retinopathy, a common complication of diabetes, is the leading cause of blindness in adults. Diabetes chronically damages retinal blood vessels and neurons likely through multiple pathogenic pathways such as oxidative stress, inflammation, and endoplasmic reticulum (ER) stress.
Jacey Hongjie Ma +2 more
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Untangling the unfolded protein response [PDF]
Cell Cycle, 2008 Resistance to current cancer therapies has forced scientists to investigate new avenues of therapy distinct from those aimed at single targets, to strategies based on targeting families of proteins, on which cancers rely for their ability to survive stress.
Emma L, Davenport +2 more
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Unfolded protein response in the COVID-19 context
Aging and Health Research, 2021 The unfolded protein response (UPR) maintains cellular homeostasis by regulating key elements of cellular growth and defense. Recent evidence suggests that this mechanism affects the vascular barrier function, by modulating lung endothelial permeability.
Nektarios Barabutis
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Melanoma and the Unfolded Protein Response [PDF]
Cancers, 2016 The UPR (unfolded protein response) has been identified as a key factor in the progression and metastasis of cancers, notably melanoma. Several mediators of the UPR are upregulated in cancers, e.g., high levels of GRP78 (glucose-regulator protein 78 kDa) correlate with progression and poor outcome in melanoma patients.
Sykes, Erin K. +2 more
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The Unfolded Protein Response and its potential role in Huntington's disease [PDF]
, 2012 Huntington's disease (HD) is a progressive, neurodegenerative disease with fatal outcome. Although the disease-causing gene (huntingtin) has been known for some time, the exact cause of neuronal cell death is still unknown.
Ravi K. R. Kalathur +2 more
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