Results 21 to 30 of about 90,832 (259)
Unfolded protein response in the COVID-19 context
Aging and Health Research, 2021 The unfolded protein response (UPR) maintains cellular homeostasis by regulating key elements of cellular growth and defense. Recent evidence suggests that this mechanism affects the vascular barrier function, by modulating lung endothelial permeability.
Nektarios Barabutis
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Untangling the unfolded protein response [PDF]
Cell Cycle, 2008 Resistance to current cancer therapies has forced scientists to investigate new avenues of therapy distinct from those aimed at single targets, to strategies based on targeting families of proteins, on which cancers rely for their ability to survive stress.
Emma L, Davenport +2 more
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Unfolded Protein Corona Surrounding Nanotubes Influence the Innate and Adaptive Immune System
Advanced Science, 2021 The plasma proteins around nanoparticles (NPs) form an outer protein corona, significantly influencing the subsequent immune response. However, it was uncertain whether the protein corona around NPs influences immune response.
Jun‐Young Park +6 more
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The unfolded protein response has a protective role in yeast models of classic galactosemia
Disease Models & Mechanisms, 2014 Classic galactosemia is a human autosomal recessive disorder caused by mutations in the GALT gene (GAL7 in yeast), which encodes the enzyme galactose-1-phosphate uridyltransferase.
Evandro A. De-Souza +6 more
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Herpesviruses and the Unfolded Protein Response [PDF]
Viruses, 2019 Herpesviruses usurp cellular stress responses to promote viral replication and avoid immune surveillance. The unfolded protein response (UPR) is a conserved stress response that is activated when the protein load in the ER exceeds folding capacity and misfolded proteins accumulate.
Benjamin P. Johnston, Craig McCormick
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Activation of mitochondrial unfolded protein response protects against multiple exogenous stressors
Life Science Alliance, 2021 This work highlights the importance of the mitochondrial unfolded protein response in allowing organisms to survive external stressors through up-regulation of other stress response pathways.
Sonja K Soo +4 more
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Unfolded Protein Responses With or Without Unfolded Proteins? [PDF]
Cells, 2012 The endoplasmic reticulum (ER) is the site of secretory protein biogenesis. The ER quality control (QC) machinery, including chaperones, ensures the correct folding of secretory proteins. Mutant proteins and environmental stresses can overwhelm the available QC machinery.
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Unfolded Protein Response and Cancer [PDF]
Discoveries, 2014 Physiological stresses, such as hypoxia and oxidative stress, induce protein misfolding in the endoplasmic reticulum (ER). If proteasome degradation fails to remove the misfolded proteins, these proteins accumulate in the ER, triggering the unfolded protein response (UPR).
Wu, Lihua, Chou, Mary, Zhu, Shudong
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Tidy up - The unfolded protein response in sepsis
Frontiers in Immunology, 2022 Pathogens, their toxic byproducts, and the subsequent immune reaction exert different forms of stress and damage to the tissue of the infected host. This stress can trigger specific transcriptional and post-transcriptional programs that have evolved to ...
Wolfgang Vivas +5 more
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eLife, 2015 Eukaryotic cells possess a variety of signaling pathways that prevent accumulation of unfolded and misfolded proteins. Chief among these is the heat shock response (HSR), which is assumed to respond to unfolded proteins in the cytosol and nucleus alike ...
Yusuke Miyazaki +4 more
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