Results 21 to 30 of about 1,143,124 (339)
Cellular Response to Unfolded Proteins in Depression [PDF]
Life, 2021 Despite many scientific studies on depression, there is no clear conception explaining the causes and mechanisms of depression development. Research conducted in recent years has shown that there is a strong relationship between depression and the endoplasmic reticulum (ER) stress.
Mateusz Kowalczyk +5 more
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The unfolded protein response [PDF]
Current Biology, 2005 Where does the UPR function? Between the endoplasmic reticulum (ER) and the nucleus of eukaryotic cells. All secreted proteins and proteins that reside in secretory compartments translocate as nascent peptide chains into the ER, where they may undergo folding, modification and assembly before assuming their functional conformations.
Chawla, Aditi, Niwa, Maho
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The Unfolding Tale of the Unfolded Protein Response [PDF]
Cell, 2001 Surface and secreted proteins are synthesized in the endoplasmic reticulum where they must fold and assemble before being transported. Changes in the ER that interfere with their proper maturation initiate the unfolded protein response pathway. New studies have filled in a missing link between the yeast and mammalian pathways.
Ma, Yanjun, Hendershot, Linda M.
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Unfolded protein response in the COVID-19 context
Aging and Health Research, 2021 The unfolded protein response (UPR) maintains cellular homeostasis by regulating key elements of cellular growth and defense. Recent evidence suggests that this mechanism affects the vascular barrier function, by modulating lung endothelial permeability.
Nektarios Barabutis
doaj +1 more source
ER Stress, the Unfolded Protein Response and Osteoclastogenesis: A Review
Biomolecules, 2023 Endoplasmic reticulum (ER) stress and its adaptive mechanism, the unfolded protein response (UPR), are triggered by the accumulation of unfolded and misfolded proteins. During osteoclastogenesis, a large number of active proteins are synthesized. When an
Wan-fang Huang, Yining Gong, Liang Yan
semanticscholar +1 more source
Untangling the unfolded protein response [PDF]
Cell Cycle, 2008 Resistance to current cancer therapies has forced scientists to investigate new avenues of therapy distinct from those aimed at single targets, to strategies based on targeting families of proteins, on which cancers rely for their ability to survive stress.
Emma L, Davenport +2 more
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The Unfolded Protein Response and Diabetic Retinopathy [PDF]
Journal of Diabetes Research, 2014 Diabetic retinopathy, a common complication of diabetes, is the leading cause of blindness in adults. Diabetes chronically damages retinal blood vessels and neurons likely through multiple pathogenic pathways such as oxidative stress, inflammation, and endoplasmic reticulum (ER) stress.
Jacey Hongjie Ma +2 more
doaj +3 more sources
Journal of Hematology & Oncology, 2022 Mitochondria are essential for tumor growth and progression. However, the heavy demand for mitochondrial activity in cancer leads to increased production of mitochondrial reactive oxygen species (mtROS), accumulation of mutations in mitochondrial DNA ...
J. Inigo, D. Chandra
semanticscholar +1 more source
Melanoma and the Unfolded Protein Response [PDF]
Cancers, 2016 The UPR (unfolded protein response) has been identified as a key factor in the progression and metastasis of cancers, notably melanoma. Several mediators of the UPR are upregulated in cancers, e.g., high levels of GRP78 (glucose-regulator protein 78 kDa) correlate with progression and poor outcome in melanoma patients.
Sykes, Erin K. +2 more
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Redox Biology, 2021 Mitochondrial dysfunction is a fundamental challenge in septic cardiomyopathy. Mitophagy and the mitochondrial unfolded protein response (UPRmt) are the predominant stress-responsive and protective mechanisms involved in repairing damaged mitochondria ...
Yue Wang +5 more
semanticscholar +1 more source