Results 1 to 10 of about 17,435 (167)

The Association of Tau With Mitochondrial Dysfunction in Alzheimer's Disease

Frontiers in Neuroscience, 2018
Increasing evidence suggests that abnormally hyperphosphorylated tau plays a vital role in the pathogenesis of Alzheimer's disease (AD). Mitochondrial dysfunction also has a recognized role in the pathophysiology of AD.
Ying Cheng, , Bai Feng
exaly   +3 more sources

Mitochondrial dysfunction and its association with age-related disorders

Frontiers in Physiology
Aging is a complex process that features a functional decline in many organelles. Various factors influence the aging process, such as chromosomal abnormalities, epigenetic changes, telomere shortening, oxidative stress, and mitochondrial dysfunction ...
Antara Banerjee, Surajit Pathak, Asim K Duttaroy   +2 more
exaly   +3 more sources

Mitochondrial dysfunction by TFAM depletion disrupts self-renewal and lineage differentiation of human PSCs by affecting cell proliferation and YAP response

Redox Biology, 2022
Genetic mitochondrial dysfunction is frequently associated with various embryonic developmental defects. However, how mitochondria contribute to early development and cell fate determination is poorly studied, especially in humans.
Yan Qi, Yida Ye, Ruxiang Wang, Senlin Yu, Yue Zhang, Jing Lv, Wenwen Jin, Shutao Xia, Wei Jiang, Yifei Li, Donghui Zhang   +10 more
doaj   +1 more source

Mitochondrial Dysfunction in Rheumatoid Arthritis

Biomolecules, 2022
Rheumatoid arthritis, a chronic autoimmune disease with complex etiology, is characterized by excessive proliferation of synovial cells, massive production of inflammatory cells and cartilage destruction. Studies have shown that mitochondrial dysfunction
Chen Ma, Jie Wang, Fenfang Hong, Shulong Yang   +3 more
doaj   +1 more source

Ras-ERK-ETS inhibition alleviates neuronal mitochondrial dysfunction by reprogramming mitochondrial retrograde signaling. [PDF]

PLoS Genetics, 2018
Mitochondrial dysfunction activates the mitochondrial retrograde signaling pathway, resulting in large scale changes in gene expression. Mitochondrial retrograde signaling in neurons is poorly understood and whether retrograde signaling contributes to ...
Olivia F Duncan, Lucy Granat, Ramya Ranganathan, Vandana K Singh, David Mazaud, Manolis Fanto, David Chambers, Clive G Ballard, Joseph M Bateman   +8 more
doaj   +1 more source

Glucose- and Non-Glucose-Induced Mitochondrial Dysfunction in Diabetic Kidney Disease

Biomolecules, 2022
Mitochondrial dysfunction plays an important role in the pathogenesis and progression of diabetic kidney disease (DKD). In this review, we will discuss mitochondrial dysfunction observed in preclinical models of DKD as well as in clinical DKD with a ...
Marie Ito, Margaret Zvido Gurumani, Sandra Merscher, Alessia Fornoni   +3 more
doaj   +1 more source

Potential Therapeutic Role of Phytochemicals to Mitigate Mitochondrial Dysfunctions in Alzheimer’s Disease

Antioxidants, 2020
Alzheimer’s disease (AD) is a progressive neurodegenerative disorder characterized by a decline in cognitive function and neuronal damage. Although the precise pathobiology of AD remains elusive, accumulating evidence suggests that mitochondrial ...
Md. Ataur Rahman, MD. Hasanur Rahman, Partha Biswas, Md. Shahadat Hossain, Rokibul Islam, Md. Abdul Hannan, Md Jamal Uddin, Hyewhon Rhim   +7 more
doaj   +1 more source

Construction of a mitochondrial dysfunction related signature of diagnosed model to obstructive sleep apnea

Frontiers in Genetics, 2022
Background: The molecular mechanisms underlying obstructive sleep apnea (OSA) and its comorbidities may involve mitochondrial dysfunction. However, very little is known about the relationships between mitochondrial dysfunction-related genes and OSA ...
Qian Liu, Qian Liu, Tao Hao, Lei Li, Daqi Huang, Ze Lin, Ze Lin, Yipeng Fang, Dong Wang, Xin Zhang, Xin Zhang, Xin Zhang   +11 more
doaj   +1 more source

Mitochondrial dysfunction in cancer

Menopause Review, 2014
Mitochondria are semi-autonomous organelles of eukaryotic cells. They perform crucial functions such as generating most of the cellular energy through the oxidative phosphorylation (OXPHOS) system and some other metabolic processes.
Kinga Księżakowska-Łakoma, Monika Żyła, Jacek R. Wilczyński   +2 more
doaj   +1 more source

How do yeast sense mitochondrial dysfunction?

Microbial Cell, 2016
Apart from energy transformation, mitochondria play important signaling roles. In yeast, mitochondrial signaling relies on several molecular cascades. However, it is not clear how a cell detects a particular mitochondrial malfunction. The problem is that
Dmitry A. Knorre, Svyatoslav S. Sokolov, Anna N. Zyrina, Fedor F. Severin   +3 more
doaj   +1 more source