Results 1 to 10 of about 541,087 (305)

Mitochondrial dysfunction in cancer [PDF]

Menopause Review, 2014
Mitochondria are semi-autonomous organelles of eukaryotic cells. They perform crucial functions such as generating most of the cellular energy through the oxidative phosphorylation (OXPHOS) system and some other metabolic processes.
Kinga Księżakowska-Łakoma, Monika Żyła, Jacek R. Wilczyński   +2 more
doaj   +3 more sources

Multidimensional study on mitochondrial dysfunction in pulmonary hypertension [PDF]

Frontiers in Medicine
Pulmonary hypertension (PH), as a complex clinical syndrome, can be caused by multiple pathophysiological factors. Its characteristics are similar to hemodynamic abnormalities, significant increase of pulmonary artery pressure, contraction and remodeling
Xuntao Yuan, Yutao Zhang, Yuyan Liu, Xiao Guo, Shuying Jia, Xingquan Xiong, Xiuying Sun, Zian Jin   +7 more
doaj   +2 more sources

Mitochondrial dysfunction by TFAM depletion disrupts self-renewal and lineage differentiation of human PSCs by affecting cell proliferation and YAP response

Redox Biology, 2022
Genetic mitochondrial dysfunction is frequently associated with various embryonic developmental defects. However, how mitochondria contribute to early development and cell fate determination is poorly studied, especially in humans.
Yan Qi, Yida Ye, Ruxiang Wang, Senlin Yu, Yue Zhang, Jing Lv, Wenwen Jin, Shutao Xia, Wei Jiang, Yifei Li, Donghui Zhang   +10 more
doaj   +1 more source

Mitochondrial Dysfunction in Rheumatoid Arthritis

Biomolecules, 2022
Rheumatoid arthritis, a chronic autoimmune disease with complex etiology, is characterized by excessive proliferation of synovial cells, massive production of inflammatory cells and cartilage destruction. Studies have shown that mitochondrial dysfunction
Chen Ma, Jie Wang, Fenfang Hong, Shulong Yang   +3 more
doaj   +1 more source

Glucose- and Non-Glucose-Induced Mitochondrial Dysfunction in Diabetic Kidney Disease

Biomolecules, 2022
Mitochondrial dysfunction plays an important role in the pathogenesis and progression of diabetic kidney disease (DKD). In this review, we will discuss mitochondrial dysfunction observed in preclinical models of DKD as well as in clinical DKD with a ...
Marie Ito, Margaret Zvido Gurumani, Sandra Merscher, Alessia Fornoni   +3 more
doaj   +1 more source

Ras-ERK-ETS inhibition alleviates neuronal mitochondrial dysfunction by reprogramming mitochondrial retrograde signaling. [PDF]

PLoS Genetics, 2018
Mitochondrial dysfunction activates the mitochondrial retrograde signaling pathway, resulting in large scale changes in gene expression. Mitochondrial retrograde signaling in neurons is poorly understood and whether retrograde signaling contributes to ...
Olivia F Duncan, Lucy Granat, Ramya Ranganathan, Vandana K Singh, David Mazaud, Manolis Fanto, David Chambers, Clive G Ballard, Joseph M Bateman   +8 more
doaj   +1 more source

Potential Therapeutic Role of Phytochemicals to Mitigate Mitochondrial Dysfunctions in Alzheimer’s Disease

Antioxidants, 2020
Alzheimer’s disease (AD) is a progressive neurodegenerative disorder characterized by a decline in cognitive function and neuronal damage. Although the precise pathobiology of AD remains elusive, accumulating evidence suggests that mitochondrial ...
Md. Ataur Rahman, MD. Hasanur Rahman, Partha Biswas, Md. Shahadat Hossain, Rokibul Islam, Md. Abdul Hannan, Md Jamal Uddin, Hyewhon Rhim   +7 more
doaj   +1 more source

Construction of a mitochondrial dysfunction related signature of diagnosed model to obstructive sleep apnea

Frontiers in Genetics, 2022
Background: The molecular mechanisms underlying obstructive sleep apnea (OSA) and its comorbidities may involve mitochondrial dysfunction. However, very little is known about the relationships between mitochondrial dysfunction-related genes and OSA ...
Qian Liu, Qian Liu, Tao Hao, Lei Li, Daqi Huang, Ze Lin, Ze Lin, Yipeng Fang, Dong Wang, Xin Zhang, Xin Zhang, Xin Zhang   +11 more
doaj   +1 more source

Mitochondrial Dysfunction in Depression [PDF]

Current Neuropharmacology, 2016
Depression is the most debilitating neuropsychiatric disorder with significant impact on socio-occupational and well being of individual. The exact pathophysiology of depression is still enigmatic though various theories have been put forwarded. There are evidences showing that mitochondrial dysfunction in various brain regions is associated with ...
Bansal, Yashika, Kuhad, Anurag
openaire   +2 more sources

Mitochondrial Dysfunction in Atherosclerosis [PDF]

Circulation Research, 2007
Increased production of reactive oxygen species in mitochondria, accumulation of mitochondrial DNA damage, and progressive respiratory chain dysfunction are associated with atherosclerosis or cardiomyopathy in human investigations and animal models of oxidative stress.
Nageswara R, Madamanchi, Marschall S, Runge   +1 more
openaire   +2 more sources