Results 1 to 10 of about 375,669 (118)

Mitochondrial dysfunction by TFAM depletion disrupts self-renewal and lineage differentiation of human PSCs by affecting cell proliferation and YAP response

Redox Biology, 2022
Genetic mitochondrial dysfunction is frequently associated with various embryonic developmental defects. However, how mitochondria contribute to early development and cell fate determination is poorly studied, especially in humans.
Yan Qi, Yida Ye, Ruxiang Wang, Senlin Yu, Yue Zhang, Jing Lv, Wenwen Jin, Shutao Xia, Wei Jiang, Yifei Li, Donghui Zhang   +10 more
doaj   +3 more sources

Ameliorating Mitochondrial Dysfunction of Neurons by Biomimetic Targeting Nanoparticles Mediated Mitochondrial Biogenesis to Boost the Therapy of Parkinson's Disease

Advanced Science, 2023
Mitochondrial dysfunction of neurons is the core pathogenesis of incurable Parkinson's disease (PD). It is crucial to ameliorate the mitochondrial dysfunction of neurons for boosting the therapy of PD.
Qing Zheng, Hanghang Liu, Hao Zhang, Yaobao Han, Jiaxin Yuan, Tingting Wang, Yifan Gao, Zhen Li   +7 more
doaj   +2 more sources

Mitochondrial Dysfunction in Rheumatoid Arthritis

Biomolecules, 2022
Rheumatoid arthritis, a chronic autoimmune disease with complex etiology, is characterized by excessive proliferation of synovial cells, massive production of inflammatory cells and cartilage destruction. Studies have shown that mitochondrial dysfunction
Chen Ma, Jie Wang, Fenfang Hong, Shulong Yang   +3 more
doaj   +1 more source

Ras-ERK-ETS inhibition alleviates neuronal mitochondrial dysfunction by reprogramming mitochondrial retrograde signaling. [PDF]

PLoS Genetics, 2018
Mitochondrial dysfunction activates the mitochondrial retrograde signaling pathway, resulting in large scale changes in gene expression. Mitochondrial retrograde signaling in neurons is poorly understood and whether retrograde signaling contributes to ...
Olivia F Duncan, Lucy Granat, Ramya Ranganathan, Vandana K Singh, David Mazaud, Manolis Fanto, David Chambers, Clive G Ballard, Joseph M Bateman   +8 more
doaj   +1 more source

Glucose- and Non-Glucose-Induced Mitochondrial Dysfunction in Diabetic Kidney Disease

Biomolecules, 2022
Mitochondrial dysfunction plays an important role in the pathogenesis and progression of diabetic kidney disease (DKD). In this review, we will discuss mitochondrial dysfunction observed in preclinical models of DKD as well as in clinical DKD with a ...
Marie Ito, Margaret Zvido Gurumani, Sandra Merscher, Alessia Fornoni   +3 more
doaj   +1 more source

Potential Therapeutic Role of Phytochemicals to Mitigate Mitochondrial Dysfunctions in Alzheimer’s Disease

Antioxidants, 2020
Alzheimer’s disease (AD) is a progressive neurodegenerative disorder characterized by a decline in cognitive function and neuronal damage. Although the precise pathobiology of AD remains elusive, accumulating evidence suggests that mitochondrial ...
Md. Ataur Rahman, MD. Hasanur Rahman, Partha Biswas, Md. Shahadat Hossain, Rokibul Islam, Md. Abdul Hannan, Md Jamal Uddin, Hyewhon Rhim   +7 more
doaj   +1 more source

Construction of a mitochondrial dysfunction related signature of diagnosed model to obstructive sleep apnea

Frontiers in Genetics, 2022
Background: The molecular mechanisms underlying obstructive sleep apnea (OSA) and its comorbidities may involve mitochondrial dysfunction. However, very little is known about the relationships between mitochondrial dysfunction-related genes and OSA ...
Qian Liu, Qian Liu, Tao Hao, Lei Li, Daqi Huang, Ze Lin, Ze Lin, Yipeng Fang, Dong Wang, Xin Zhang, Xin Zhang, Xin Zhang   +11 more
doaj   +1 more source

Mitochondrial dysfunction in cancer

Menopause Review, 2014
Mitochondria are semi-autonomous organelles of eukaryotic cells. They perform crucial functions such as generating most of the cellular energy through the oxidative phosphorylation (OXPHOS) system and some other metabolic processes.
Kinga Księżakowska-Łakoma, Monika Żyła, Jacek R. Wilczyński   +2 more
doaj   +1 more source

Porphyromonas gingivalis infection promotes mitochondrial dysfunction through Drp1-dependent mitochondrial fission in endothelial cells

International Journal of Oral Science, 2021
Porphyromonas gingivalis (P. gingivalis), a key pathogen in periodontitis, has been shown to accelerate the progression of atherosclerosis (AS). However, the definite mechanisms remain elusive.
Tong Xu, Qin Dong, Yuxiao Luo, Yanqing Liu, Liang Gao, Yaping Pan, Dongmei Zhang   +6 more
doaj   +1 more source

Mitochondria Targeted Antioxidant Significantly Alleviates Preeclampsia Caused by 11β-HSD2 Dysfunction via OPA1 and MtDNA Maintenance

Antioxidants, 2022
We have previously demonstrated that placental 11β-hydroxysteroid dehydrogenase type 2 (11β-HSD2) dysfunction contributes to PE pathogenesis. We sought to elucidate molecular mechanisms underlying 11β-HSD2 dysfunction-induced PE and to seek potential ...
Jing Long, Yan Huang, Zhengshan Tang, Yali Shan, Dou Feng, Wenqin Wang, Juan Liu, Ying Huang, Hang Gu, Dewei Guo, Ruojin Yao, Xin Ni   +11 more
doaj   +1 more source