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Mitochondrial dysfunction in cancer [PDF]
Menopause Review, 2014 Mitochondria are semi-autonomous organelles of eukaryotic cells. They perform crucial functions such as generating most of the cellular energy through the oxidative phosphorylation (OXPHOS) system and some other metabolic processes.
Kinga Księżakowska-Łakoma +2 more
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Redox Biology, 2022 Genetic mitochondrial dysfunction is frequently associated with various embryonic developmental defects. However, how mitochondria contribute to early development and cell fate determination is poorly studied, especially in humans.
Yan Qi +10 more
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How do yeast sense mitochondrial dysfunction?
Microbial Cell, 2016 Apart from energy transformation, mitochondria play important signaling roles. In yeast, mitochondrial signaling relies on several molecular cascades. However, it is not clear how a cell detects a particular mitochondrial malfunction. The problem is that
Dmitry A. Knorre +3 more
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Advanced Science, 2023 Mitochondrial dysfunction of neurons is the core pathogenesis of incurable Parkinson's disease (PD). It is crucial to ameliorate the mitochondrial dysfunction of neurons for boosting the therapy of PD.
Qing Zheng +7 more
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The Association of Tau With Mitochondrial Dysfunction in Alzheimer's Disease
Frontiers in Neuroscience, 2018 Increasing evidence suggests that abnormally hyperphosphorylated tau plays a vital role in the pathogenesis of Alzheimer's disease (AD). Mitochondrial dysfunction also has a recognized role in the pathophysiology of AD.
Ying Cheng, Feng Bai
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Mitigating mitochondrial dysfunction: a novel strategy for Chinese botanical drugs against osteoporosis [PDF]
Frontiers in PharmacologyOsteoporosis (OP) is a chronic metabolic disease characterized by reduced bone mass and impaired bone microstructure, posing a significant global health threat.
Shiyu Li, Hongyu Liu
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The Roads to Mitochondrial Dysfunction [PDF]
BioMed Research International, 2015 This eclectic collection of papers reflects various aspects of the current understanding of the interplay between the functioning of the mitochondrial genome, the components of respiratory chain it encodes, and the mutual influences of the mitochondria and the cell and discusses potential impact of the mitochondrial dysfunction on some health ...
Marcos Roberto de Oliveira +3 more
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Mitochondrial Dysfunction in Rheumatoid Arthritis
Biomolecules, 2022 Rheumatoid arthritis, a chronic autoimmune disease with complex etiology, is characterized by excessive proliferation of synovial cells, massive production of inflammatory cells and cartilage destruction. Studies have shown that mitochondrial dysfunction
Chen Ma +3 more
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Ras-ERK-ETS inhibition alleviates neuronal mitochondrial dysfunction by reprogramming mitochondrial retrograde signaling. [PDF]
PLoS Genetics, 2018 Mitochondrial dysfunction activates the mitochondrial retrograde signaling pathway, resulting in large scale changes in gene expression. Mitochondrial retrograde signaling in neurons is poorly understood and whether retrograde signaling contributes to ...
Olivia F Duncan +8 more
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Glucose- and Non-Glucose-Induced Mitochondrial Dysfunction in Diabetic Kidney Disease
Biomolecules, 2022 Mitochondrial dysfunction plays an important role in the pathogenesis and progression of diabetic kidney disease (DKD). In this review, we will discuss mitochondrial dysfunction observed in preclinical models of DKD as well as in clinical DKD with a ...
Marie Ito +3 more
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