Reversible mitochondrial respiratory chain impairment during symptomatic hyperlactatemia associated with antiretroviral therapy [PDF]
, 2013 Direct evidence confirming the hypothesis that a dysfunction of the mitochondrial respiratory chain (MRC) underlies the pathogenesis of hyperlactatemia associated with highly active antiretroviral therapy (HAART) is scarce.
Miró Meda, José M. (José María), 1956- +10 more
core +1 more source
Mitochondrial Dysfunction in Autism [PDF]
JAMA, 2010 Impaired mitochondrial function may influence processes highly dependent on energy, such as neurodevelopment, and contribute to autism. No studies have evaluated mitochondrial dysfunction and mitochondrial DNA (mtDNA) abnormalities in a well-defined population of children with autism.To evaluate mitochondrial defects in children with autism ...
Giulivi, Cecilia +7 more
openaire +4 more sources
Deceleration of fusion–fission cycles improves mitochondrial quality control during aging [PDF]
, 2012 Mitochondrial dynamics and mitophagy play a key role in ensuring mitochondrial quality control. Impairment thereof was proposed to be causative to neurodegenerative diseases, diabetes, and cancer.
Michael Meyer-Hermann +18 more
core +2 more sources
PLoS ONE, 2021 Mitochondrial dysfunction is significantly associated with neurological deficits and age-related neurological diseases. While mitochondria are dynamically regulated and properly maintained during neurogenesis, the manner in which mitochondrial activities
Rintaro Kuroda +9 more
doaj +1 more source
Ubiquitin-proteasome dependent mitochondrial protein quality control [PDF]
, 2014 Dysfunctional mitochondria cause many neurodegenerative disorders and with aging in general, mechanisms of mitochondrial quality control are essential for cellular function.
Benischke, Anne-Sophie
core +1 more source
Mechanisms of hepatocellular toxicity associated with dronedarone and other mitochondrial toxicants [PDF]
, 2014 Idiosyncratic drug-induced liver injury is a rare toxic event that typically occurs at therapeutic doses, which are generally safe to the majority of patients.
Felser, Andrea Debora
core +1 more source
Advances in exercise to alleviate sarcopenia in older adults by improving mitochondrial dysfunction
Frontiers in Physiology, 2023 Sarcopenia is a chronic degenerative disease affecting primarily older adults. A growing aging population is gradually increasing the number of patients suffering from sarcopenia, placing increasing financial pressure on patients’ families and society in
Yang Zhu +5 more
doaj +1 more source
Neurodegenerative stress related mitochondrial proteostasis [PDF]
, 2015 1.1 Background: Mitochondria are the main site of energy production in most cells. Furthermore, they are involved in a multitude of other essential cellular processes, such as regulating the cellular calcium pool, lipid metabolism and programmed cell ...
Fang, Lei
core +1 more source
Geniposide Protects Primary Cortical Neurons against Oligomeric Aβ1-42-Induced Neurotoxicity through a Mitochondrial Pathway. [PDF]
PLoS ONE, 2016 Mitochondrial dysfunction plays a key role in the progression of Alzheimer's disease (AD). The accumulation of amyloid-beta peptide (Aβ) in the brains of AD patients is thought to be closely related to neuronal mitochondrial dysfunction and oxidative ...
Chunhui Zhao +7 more
doaj +1 more source
Mitochondrial Regulation of Diabetic Kidney Disease
Frontiers in Medicine, 2021 The role and nature of mitochondrial dysfunction in diabetic kidney disease (DKD) has been extensively studied. Yet, the molecular drivers of mitochondrial remodeling in DKD are poorly understood.
Daniel L. Galvan +4 more
doaj +1 more source