Results 31 to 40 of about 541,087 (305)

Recent advances and new perspectives in mitochondrial dysfunction

Scientific Reports, 2023
In the last decade, there has been an increased appreciation for mitochondria as central hubs in diverse processes, such as cellular energy, immunity, and signal transduction.
Cecilia Giulivi, Kezhong Zhang, Hirofumi Arakawa   +2 more
doaj   +1 more source

No excess of mitochondrial DNA deletions within muscle in progressive multiple sclerosis [PDF]

, 2013
BACKGROUND: Mitochondrial dysfunction is an established feature of multiple sclerosis (MS). We recently described high levels of mitochondrial DNA (mtDNA) deletions within respiratory enzyme-deficient (lacking mitochondrial respiratory chain complex IV ...
Abadi A, Amy K Reeve, Brierley EJ, Broadwater L, Campbell GR, Campbell GR, Campbell GR, Campbell GR, Don J Mahad, Doug M Turnbull, Dutta R, Dutta R, Graham R Campbell, Harding AE, Horvath R, Iryna Ziabreva, Johnson MA, Krishnan KJ, Kumleh HH, Larsson NG, Mahler A, McFarland R, Murphy JL, Nociti V, Palace J, Parise G, Patte M, Rahman S, Rahman S, Reeve AK, Richard Reynolds, Sakiyama Y, Taylor RW, Verny C, Witte ME, Witte ME, Yu-Wai-Man P   +36 more
core   +2 more sources

Peroxynitrite-Mediated Mitochondrial Dysfunction

Neurosignals, 2001
Peroxynitrite anion (ONOO(-)) is a potent biological oxidant produced by the near diffusion-limited reaction of superoxide and nitric oxide. Peroxynitrite has been implicated in diverse forms of free radical-induced tissue injury. Experimental evidence showed that exogenous and endogenous peroxynitrite causes alterations of the structure and function ...
J, Boczkowski, C L, Lisdero, S, Lanone, M C, Carreras, M, Aubier, J J, Poderoso   +5 more
openaire   +2 more sources

Mitochondrial Dysfunction Accelerates Ageing

Immunometabolism, 2020
Abstract We review here the seminal findings of Desdin-Mico et al. showing that T cells with dysfunctional mitochondria induce multimorbity and premature senescence, due to mitochondrial transcription factor A (TFAM). They add further weight to the idea that targeting immunometabolism could be beneficial in combating the ...
Schroth, J, Henson, SM
openaire   +3 more sources

Mitochondrial dysfunction in obesity [PDF]

Current Opinion in Endocrinology, Diabetes and Obesity, 2010
The review highlights recent findings regarding the functions of mitochondria in adipocytes, providing an understanding of their central roles in regulating substrate metabolism, energy expenditure, disposal of reactive oxygen species (ROS), and in the pathophysiology of obesity and insulin resistance, as well as roles in the mechanisms that affect ...
Juan C, Bournat, Chester W, Brown
openaire   +2 more sources

Anti-oxidants in Parkinson's disease therapy: a critical point of view [PDF]

, 2016
Parkinson's disease (PD) is a degenerative neurological syndrome, which is characterized by the preferential death of dopaminergic (DAergic) neurons in the SubstantiaNigra.
Beltramini, Mariano, Bisaglia, Marco, Bubacco, Luigi, Filograna, Roberta   +3 more
core   +2 more sources

Loss of mitochondrial transcription factor A in neural stem cells leads to immature brain development and triggers the activation of the integral stress response in vivo.

PLoS ONE, 2021
Mitochondrial dysfunction is significantly associated with neurological deficits and age-related neurological diseases. While mitochondria are dynamically regulated and properly maintained during neurogenesis, the manner in which mitochondrial activities
Rintaro Kuroda, Kaoru Tominaga, Katsumi Kasashima, Kenji Kuroiwa, Eiji Sakashita, Hiroko Hayakawa, Tom Kouki, Nobuhiko Ohno, Kensuke Kawai, Hitoshi Endo   +9 more
doaj   +1 more source

Hormone deprivation alters mitochondrial function and lipid profile in the hippocampus [PDF]

, 2017
Mitochondrial dysfunction is a common hallmark in aging. In the female, reproductive senescence is characterized by loss of ovarian hormones, many of whose neuroprotective effects converge upon mitochondria.
Alvarez, Silvia, Astiz, Mariana, Imsen, Mercedes, Magnani, Natalia Daniela, Merino, Florencia, Reines, Analia Gabriela, Seilicovich, Adriana, Zarate, Sandra Cristina   +7 more
core   +2 more sources

Mitochondrial Dysfunction in Cancer [PDF]

Frontiers in Oncology, 2013
A mechanistic understanding of how mitochondrial dysfunction contributes to cell growth and tumorigenesis is emerging beyond Warburg as an area of research that is under-explored in terms of its significance for clinical management of cancer. Work discussed in this review focuses less on the Warburg effect and more on mitochondria and how dysfunctional
Boland, Michelle L., Chourasia, Aparajita H., Macleod, Kay F.   +2 more
openaire   +3 more sources

Research Progress on the Relationship between Mitochondrial Dysfunction and Post-stroke Depression [PDF]

Zhongguo quanke yixue, 2022
Post-stroke depression (PSD) is one of the most common emotional disorders that occurs after cerebrovascular diseases, with core symptoms mainly including low mood, loss of interest, and behavioral inhibition.
Zhimin DING, Kaiqi SU, Jing GAO, Tingyu CHEN, Yixuan FENG, Xiaodong FENG
doaj   +1 more source