Results 11 to 20 of about 1,226,681 (303)

How do yeast sense mitochondrial dysfunction?

Microbial Cell, 2016
Apart from energy transformation, mitochondria play important signaling roles. In yeast, mitochondrial signaling relies on several molecular cascades. However, it is not clear how a cell detects a particular mitochondrial malfunction. The problem is that
Dmitry A. Knorre, Svyatoslav S. Sokolov, Anna N. Zyrina, Fedor F. Severin   +3 more
doaj   +2 more sources

Respiratory chain dysfunction associated with multiple mitochondrial DNA deletions in antiretroviral therapy-related lipodystrophy. [PDF]

, 2013
Highly-active antiretroviral therapy (HAART) can induce a characteristic lipodystrophy syndrome characterized by peripheral fat wasting and central adiposity, usually associated with hyperlipidaemia and insulin resistance [1,2].
Cardellach, Francesc, Pedrol, Enric, Nunes Martínez, Virginia, Casademont i Pou, Jordi, Miró i Andreu, Òscar, Gómez, Montserrat   +5 more
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The Roads to Mitochondrial Dysfunction [PDF]

BioMed Research International, 2015
This eclectic collection of papers reflects various aspects of the current understanding of the interplay between the functioning of the mitochondrial genome, the components of respiratory chain it encodes, and the mutual influences of the mitochondria and the cell and discusses potential impact of the mitochondrial dysfunction on some health ...
Marcos Roberto de Oliveira, Namasivayam Elangovan, Marko Ljubkovic, Ancha Baranova   +3 more
openaire   +4 more sources

Mitochondrial Dysfunction in Depression [PDF]

Current Neuropharmacology, 2016
Depression is the most debilitating neuropsychiatric disorder with significant impact on socio-occupational and well being of individual. The exact pathophysiology of depression is still enigmatic though various theories have been put forwarded. There are evidences showing that mitochondrial dysfunction in various brain regions is associated with ...
Bansal, Yashika, Kuhad, Anurag
openaire   +2 more sources

Mitochondrial Dysfunction in Atherosclerosis [PDF]

Circulation Research, 2007
Increased production of reactive oxygen species in mitochondria, accumulation of mitochondrial DNA damage, and progressive respiratory chain dysfunction are associated with atherosclerosis or cardiomyopathy in human investigations and animal models of oxidative stress.
Nageswara R, Madamanchi, Marschall S, Runge   +1 more
openaire   +2 more sources

Mitochondrial dysfunction in obesity [PDF]

Current Opinion in Endocrinology, Diabetes and Obesity, 2010
The review highlights recent findings regarding the functions of mitochondria in adipocytes, providing an understanding of their central roles in regulating substrate metabolism, energy expenditure, disposal of reactive oxygen species (ROS), and in the pathophysiology of obesity and insulin resistance, as well as roles in the mechanisms that affect ...
Juan C, Bournat, Chester W, Brown
openaire   +2 more sources

Parkinson phenotype in aged PINK1-deficient mice is accompanied by progressive mitochondrial dysfunction in absence of neurodegeneration [PDF]

, 2009
Background Parkinson's disease (PD) is an adult-onset movement disorder of largely unknown etiology. We have previously shown that loss-of-function mutations of the mitochondrial protein kinase PINK1 (PTEN induced putative kinase 1) cause the recessive ...
Rüb Udo, Jendrach, M., Wenzel, Dirk, Auburger Georg, Miguel Barrera, Nussbaum, Robert L, Leuner, K., Hoepken, Hans Hermann, Amy Chen, Kudin, Alexei P, Auburger, Georg, Mekhman Azizov, Zimmermann, Annabelle, Zimmerman, Annabelle, Fernández-Ruiz, Javier, Dorothea Becker, Nussbaum, R., Becker, D., Auburger, G., Gispert, Suzana, Zimmermann Annabelle, Hoepken, Hans-Hermann, Nussbaum, Robert L., Robert L Nussbaum, Hoepken, H., Müller Walter E., Leslie Huber, Müller, Walter E., Gispert Suzana, García-Arencíbia, Moisés, Roeper Jochen, Ricciardi Filomena, Jendrach Marina, Dirk Wenzel, Kurz, A., Kurz Alexander, Voos, W., Azizov Mekhman, Kunz Wolfram S., Kurz, Alexander, Jendrach, Marina, Jochen Roeper, Müller, W., Wenzel, D., Rohrer, Hermann, Gispert, S., Hoepken Hans-Hermann, Azizov, M., Andreas S Reichert, Udo Rüb, Voos, Wolfgang, Reichert, Andreas S., Kristina Leuner, Rohrer, H., Kunz, Wolfram S, Javier Fernández-Ruiz, Barrera Miguel, Rüb, Udo, Wenzel Dirk, Chen Amy, Becker Dorothea, Rüb, U., Marina Jendrach, Müller, Walter E, Chen, A., Barrera, Miguel, Moisés García-Arencíbia, Fernández-Ruiz Javier, Wolfram S Kunz, Kudin, Alexei P., Reichert, A., Annabelle Zimmermann, Fernández-Ruiz, J., Kunz, W., Leuner Kristina, Rohrer Hermann, Alexander Kurz, Reichert Andreas S., Alexei P Kudin, Hermann Rohrer, Azizov, Mekhman, Reichert, Andreas, Zimmermann, A., Walter E Müller, Barrera, M., García-Arencíbia Moisés, Nussbaum Robert L., Roeper, Jochen, Chen, Amy, Filomena Ricciardi, Hans-Hermann Hoepken, Kudin Alexei P., Huber, L., Suzana Gispert, García-Arencíbia, M., Becker, Dorothea, Reichert, Andreas S, Georg Auburger, Huber Leslie, Ricciardi, Filomena, Ricciardi, F., Kunz, Wolfram S., Kudin, A., Leuner, Kristina, Roeper, J., Wolfgang Voos, Voos Wolfgang, Huber, Leslie   +107 more
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Mitochondrial Dysfunction in Cancer [PDF]

Frontiers in Oncology, 2013
A mechanistic understanding of how mitochondrial dysfunction contributes to cell growth and tumorigenesis is emerging beyond Warburg as an area of research that is under-explored in terms of its significance for clinical management of cancer. Work discussed in this review focuses less on the Warburg effect and more on mitochondria and how dysfunctional
Boland, Michelle L., Chourasia, Aparajita H., Macleod, Kay F.   +2 more
openaire   +3 more sources

TOM40 Mediates Mitochondrial Dysfunction Induced by α-Synuclein Accumulation in Parkinson's Disease. [PDF]

, 2013
Alpha-synuclein (α-Syn) accumulation/aggregation and mitochondrial dysfunction play prominent roles in the pathology of Parkinson's disease. We have previously shown that postmortem human dopaminergic neurons from PD brains accumulate high levels of ...
Adame, Anthony, Mueller, Sarina, Bender Andreas, Sarina Mueller, Koob Andrew O., Elstner Matthias, Elstner, Matthias, Desplats, Paula, Mante, Michael, Eliezer Masliah, Desplats Paula, Mueller Sarina, Spencer, Brian, Matthias Elstner, Thomas Klopstock, Masliah, Eliezer, Koob, Andrew O., Andreas Bender, Bender, Andreas, Masliah Eliezer, Anthony Adame, Klopstock Thomas, Rockenstein, Edward, Laub Christoph, Rockenstein Edward, Pham Emily, Brian Spencer, Mante Michael, Michael Mante, Klopstock, Thomas, Christoph Laub, Spencer Brian, Adame Anthony, Andrew O Koob, Paula Desplats, Emily Pham, Laub, Christoph, Pham, Emily, Edward Rockenstein   +38 more
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Mitochondrial dysfunction in cell senescence and aging

The Journal of Clinical Investigation, 2022
Mitochondrial dysfunction and cell senescence are hallmarks of aging and are closely interconnected. Mitochondrial dysfunction, operationally defined as a decreased respiratory capacity per mitochondrion together with a decreased mitochondrial membrane ...
Satomi Miwa, Sonu Kashyap, Eduardo Chini, Thomas von Zglinicki   +3 more
doaj   +1 more source