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Biogenesis of mitochondrial proteins [PDF]
Current Opinion in Cell Biology, 1996 Numerous components have been identified that participate at various stages in the biogenesis of mitochondria. For many of these components, their specific functions have recently been defined through detailed investigations of the molecular mechanisms underlying protein targeting, translocation across the mitochondrial outer and inner membranes ...
R, Lill, F E, Nargang, W, Neupert
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Retrograde mitochondrial transport is required for mitochondrial biogenesis in zebrafish neurons. [PDF]
Nat CommunTo maintain a functional mitochondrial population in a long-lived cell like a neuron, mitochondria must be continuously replenished through the process of mitochondrial biogenesis.
Lang AE, Stein C, Schultz R, Drerup CM.
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Regulation of Mitochondrial Biogenesis in Diabetic Retinopathy. [PDF]
CellsMitochondrial dysfunction plays a major role in diabetic retinopathy development and in its resistance to halt after the reversal of hyperglycemia (metabolic memory).
Kumar J, Kowluru RA.
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Cells, 2019 Mitochondrial biogenesis is a complex process. It requires the contribution of both the nuclear and the mitochondrial genomes and therefore cross talk between the nucleus and mitochondria.
Cyrielle Bouchez, Anne Devin
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Marine Drugs, 2014 Echinochrome A (Ech A) is a natural pigment from sea urchins that has been reported to have antioxidant properties and a cardio protective effect against ischemia reperfusion injury.
Nari Kim +2 more
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FTO-mediated m6A demethylation regulates PGC-1α-dependent mitochondrial biogenesis to attenuate aluminum-induced neuronal senescence. [PDF]
Sci RepAluminum (Al) exposure is increasingly recognized as a risk factor for neurodegenerative disorders; however, the epitranscriptomic mechanisms linking environmental Al toxicity to neuronal senescence and mitochondrial alterations remain poorly understood.
Jin Z +6 more
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Tom70-based transcriptional regulation of mitochondrial biogenesis and aging
eLife, 2022 Mitochondrial biogenesis has two major steps: the transcriptional activation of nuclear genome-encoded mitochondrial proteins and the import of nascent mitochondrial proteins that are synthesized in the cytosol.
Qingqing Liu +5 more
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Cell Communication and Signaling, 2023 Background Myoblast differentiation requires metabolic reprogramming driven by increased mitochondrial biogenesis and oxidative phosphorylation. The canonical GH-GHR-IGFs axis in liver exhibits a great complexity in response to somatic growth.
Bowen Hu +9 more
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Mitochondrial biogenesis: An update [PDF]
Journal of Cellular and Molecular Medicine, 2020 Abstract In response to the energy demand triggered by developmental signals and environmental stressors, the cells launch the mitochondrial biogenesis process. This is a self‐renewal route, by which new mitochondria are generated from the ones already existing.
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MYC and Mitochondrial Biogenesis [PDF]
Cold Spring Harbor Perspectives in Medicine, 2014 Mitochondria, the powerhouses of the cell, face two imperatives concerning biogenesis. The first is the requirement for dividing cells to replicate their mitochondrial content by growth of existing mitochondria. The second is the dynamic regulation of mitochondrial content in response to organismal and cellular cues (e.g., exercise, caloric restriction,
Fionnuala, Morrish, David, Hockenbery
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