Results 1 to 10 of about 113,851 (114)

Regulation of Mitochondrial Biogenesis in Diabetic Retinopathy [PDF]

Cells
Mitochondrial dysfunction plays a major role in diabetic retinopathy development and in its resistance to halt after the reversal of hyperglycemia (metabolic memory).
Jay Kumar, Renu A. Kowluru
doaj   +2 more sources

Echinochrome A Increases Mitochondrial Mass and Function by Modulating Mitochondrial Biogenesis Regulatory Genes

Marine Drugs, 2014
Echinochrome A (Ech A) is a natural pigment from sea urchins that has been reported to have antioxidant properties and a cardio protective effect against ischemia reperfusion injury.
Seung Hun Jeong, Hyoung Kyu Kim, In-Sung Song, Su Jin Noh, Jubert Marquez, Kyung Soo Ko, Byoung Doo Rhee, Nari Kim, Natalia P. Mishchenko, Sergey A. Fedoreyev, Valentin A. Stonik, Jin Han   +11 more
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A transcription network underlies the dual genomic coordination of mitochondrial biogenesis [PDF]

eLife
Mitochondrial biogenesis requires the expression of genes encoded by both the nuclear and mitochondrial genomes. However, aside from a handful transcription factors regulating specific subsets of mitochondrial genes, the overall architecture of the ...
Fan Zhang, Annie Lee, Anna V Freitas, Jake T Herb, Zong-Heng Wang, Snigdha Gupta, Zhe Chen, Hong Xu   +7 more
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Mitochondrial Biogenesis and Mitochondrial Reactive Oxygen Species (ROS): A Complex Relationship Regulated by the cAMP/PKA Signaling Pathway

Cells, 2019
Mitochondrial biogenesis is a complex process. It requires the contribution of both the nuclear and the mitochondrial genomes and therefore cross talk between the nucleus and mitochondria.
Cyrielle Bouchez, Anne Devin
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DNM1L-mediated fission governs mitophagy & mitochondrial biogenesis during myogenic differentiation [PDF]

Cell Communication and Signaling
Background Remodeling of the mitochondrial network is implicated in myogenesis. Remodeling processes including mitochondrial fission, mitophagy, and biogenesis are important as they finetune the mitochondrial network to meet the increased energetic ...
Fasih A. Rahman, Jasmine M. Friedrich Yap, Tyler M. Joseph, Amanda M. Adam, Sarah M. Chapman, Joe Quadrilatero   +5 more
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Histone Lactylation Couples FSH-Driven Lactate Metabolism to Mitochondrial Biogenesis by Enhancing HDAC4-Mediated Deacetylation of PGC-1α in Granulosa Cells [PDF]

Research
Follicle-stimulating hormone (FSH) coordinates ovarian follicle development by aligning mitochondrial biogenesis with increased metabolic demand. Although FSH is known to stimulate glycolysis in granulosa cells (GCs), the mechanism by which glycolytic ...
Gang Wu, Min Chen, Chengyu Li, Mengli Wei, Yitong Pan, Tong He, Zhaojun Liu, Hongmin Li, Chunlei Zhang, Jia-Qing Zhang, Yanan Sheng, Yang Liu, Honglin Liu, Ming Shen   +13 more
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Tom70-based transcriptional regulation of mitochondrial biogenesis and aging

eLife, 2022
Mitochondrial biogenesis has two major steps: the transcriptional activation of nuclear genome-encoded mitochondrial proteins and the import of nascent mitochondrial proteins that are synthesized in the cytosol.
Qingqing Liu, Catherine E Chang, Alexandra C Wooldredge, Benjamin Fong, Brian K Kennedy, Chuankai Zhou   +5 more
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Local GHR roles in regulation of mitochondrial function through mitochondrial biogenesis during myoblast differentiation

Cell Communication and Signaling, 2023
Background Myoblast differentiation requires metabolic reprogramming driven by increased mitochondrial biogenesis and oxidative phosphorylation. The canonical GH-GHR-IGFs axis in liver exhibits a great complexity in response to somatic growth.
Bowen Hu, Changbin Zhao, Xiangchun Pan, Haohui Wei, Guodong Mo, Mingjian Xian, Wen Luo, Qinghua Nie, Hongmei Li, Xiquan Zhang   +9 more
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Resveratrol Improves Mitochondrial Biogenesis Function and Activates PGC-1α Pathway in a Preclinical Model of Early Brain Injury Following Subarachnoid Hemorrhage

Frontiers in Molecular Biosciences, 2021
Peroxisome proliferator-activated receptor gamma coactivator 1-alpha (PGC-1α) has been shown to play a pivotal role in the regulation of mitochondrial biogenesis in diseases.
Jian Zhou, Zaijia Yang, Ruiming Shen, Wangwang Zhong, Huiduan Zheng, Zhenggang Chen, Jianjian Tang, Juan Zhu   +7 more
doaj   +1 more source

Reperfusion promotes mitochondrial biogenesis following focal cerebral ischemia in rats. [PDF]

PLoS ONE, 2014
BACKGROUND AND PURPOSE: Reperfusion after transient cerebral ischemia causes severe damage to mitochondria; however, little is known regarding the continuous change in mitochondrial biogenesis during reperfusion.
Yuying Xie, Jun Li, Guibo Fan, Sihua Qi, Bing Li   +4 more
doaj   +1 more source