PGC-1α Is a Master Regulator of Mitochondrial Lifecycle and ROS Stress Response
Antioxidants, 2023 Mitochondria play a major role in ROS production and defense during their life cycle. The transcriptional activator PGC-1α is a key player in the homeostasis of energy metabolism and is therefore closely linked to mitochondrial function.
Tasnim Arroum +2 more
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PGC-1α and PGC-1β Increase Protein Synthesis via ERRα in C2C12 Myotubes
Frontiers in Physiology, 2018 The transcriptional coactivators peroxisome proliferator-activated receptor-γ coactivator-1α (PGC-1α) and PGC-1β are positive regulators of skeletal muscle mass and energy metabolism; however, whether they influence muscle growth and metabolic ...
Erin L Brown +2 more
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PGC-1α: key regulator of mitochondrial biogenesis and cellular differentiation in metabolic and regenerative tissues [PDF]
Cell & BiosciencePeroxisome proliferator-activated receptor γ coactivator 1α (PGC-1α) is a crucial coactivator that regulates mitochondrial biogenesis and function across diverse tissues, including the brain, heart, skeletal muscle, bone marrow, and liver.
Lijuan Cao +9 more
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Skeletal muscle‐specific PGC‐1α‐b overexpression prevents eccentric contraction‐induced muscle injury through an utrophin‐independent pathway in mice [PDF]
Physiological ReportsSlower oxidative fibers are more resistant to eccentric contraction (ECC)‐induced muscle damage than fast‐twitch glycolytic fibers, but the mechanisms remain unclear. This study investigated the roles of the exercise‐inducible PGC‐1α isoform PGC‐1α‐b and
Azuma Naito +7 more
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Brain Sciences, 2021 The pharmacological induction and activation of peroxisome proliferator-activated receptor gamma coactivator 1 alpha (PGC-1α), a key regulator of ischemic brain tolerance, is a promising direction in neuroprotective therapy.
Fatima M. Shakova +4 more
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Glucocorticoids Alter CRTC-CREB Signaling in Muscle Cells: Impact on PGC-1α Expression and Atrophy Markers. [PDF]
PLoS ONE, 2016 Muscle wasting associated with chronic diseases has been linked to decreased expression of PGC-1α and overexpression of PGC-1α counters muscle loss. CREB, in conjunction with the CREB-regulated transcription coactivator (CRTC2), is a positive modulator ...
Jill A Rahnert +4 more
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Regulation of Brown and White Adipocyte Transcriptome by the Transcriptional Coactivator NT-PGC-1α. [PDF]
PLoS ONE, 2016 The β3-adrenergic receptor (AR) signaling pathway is a major component of adaptive thermogenesis in brown and white adipose tissue during cold acclimation.
Jihyun Kim +7 more
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Covering the Role of PGC-1α in the Nervous System
Cells, 2021 The peroxisome proliferator-activated receptor-γ coactivator-1α (PGC-1α) is a well-known transcriptional coactivator involved in mitochondrial biogenesis.
Zuzanna Kuczynska +3 more
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ApoE-/- PGC-1α-/- mice display reduced IL-18 levels and do not develop enhanced atherosclerosis. [PDF]
PLoS ONE, 2010 Atherosclerosis is a chronic inflammatory disease that evolves from the interaction of activated endothelial cells, macrophages, lymphocytes and modified lipoproteins (LDLs).
Sokrates Stein +6 more
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Epigenetic Modifications of the PGC-1α Promoter during Exercise Induced Expression in Mice. [PDF]
PLoS ONE, 2015 The transcriptional coactivator, PGC-1α, is known for its role in mitochondrial biogenesis. Although originally thought to exist as a single protein isoform, recent studies have identified additional promoters which produce multiple mRNA transcripts. One
Timothy L Lochmann +3 more
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