Cerebellar transcriptional alterations with Purkinje cell dysfunction and loss in mice lacking PGC-1α [PDF]
Frontiers in Cellular Neuroscience, 2015 Alterations in the expression and activity of the transcriptional coactivator peroxisome proliferator-activated receptor γ coactivator-1α (ppargc1a or PGC-1α) have been reported in multiple movement disorders, yet it is unclear how a lack of PGC-1α ...
Elizabeth K Lucas +7 more
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The asymmetric binding of PGC-1α to the ERRα and ERRγ nuclear receptor homodimers involves a similar recognition mechanism. [PDF]
PLoS ONE, 2013 BackgroundPGC-1α is a crucial regulator of cellular metabolism and energy homeostasis that functionally acts together with the estrogen-related receptors (ERRα and ERRγ) in the regulation of mitochondrial and metabolic gene networks.
Maria Takacs +11 more
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PGC-1α Is a Master Regulator of Mitochondrial Lifecycle and ROS Stress Response
Antioxidants, 2023 Mitochondria play a major role in ROS production and defense during their life cycle. The transcriptional activator PGC-1α is a key player in the homeostasis of energy metabolism and is therefore closely linked to mitochondrial function.
Silke Morris, Karin Busch, Tasnim Arroum
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PGC-1α: key regulator of mitochondrial biogenesis and cellular differentiation in metabolic and regenerative tissues [PDF]
Cell & BiosciencePeroxisome proliferator-activated receptor γ coactivator 1α (PGC-1α) is a crucial coactivator that regulates mitochondrial biogenesis and function across diverse tissues, including the brain, heart, skeletal muscle, bone marrow, and liver.
Lijuan Cao +9 more
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Brain Sciences, 2021 The pharmacological induction and activation of peroxisome proliferator-activated receptor gamma coactivator 1 alpha (PGC-1α), a key regulator of ischemic brain tolerance, is a promising direction in neuroprotective therapy.
Fatima M. Shakova +4 more
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Glucocorticoids Alter CRTC-CREB Signaling in Muscle Cells: Impact on PGC-1α Expression and Atrophy Markers. [PDF]
PLoS ONE, 2016 Muscle wasting associated with chronic diseases has been linked to decreased expression of PGC-1α and overexpression of PGC-1α counters muscle loss. CREB, in conjunction with the CREB-regulated transcription coactivator (CRTC2), is a positive modulator ...
Jill A Rahnert +4 more
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Covering the Role of PGC-1α in the Nervous System
Cells, 2021 The peroxisome proliferator-activated receptor-γ coactivator-1α (PGC-1α) is a well-known transcriptional coactivator involved in mitochondrial biogenesis.
Zuzanna Kuczynska +3 more
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Regulation of Brown and White Adipocyte Transcriptome by the Transcriptional Coactivator NT-PGC-1α. [PDF]
PLoS ONE, 2016 The β3-adrenergic receptor (AR) signaling pathway is a major component of adaptive thermogenesis in brown and white adipose tissue during cold acclimation.
Jihyun Kim +7 more
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ApoE-/- PGC-1α-/- mice display reduced IL-18 levels and do not develop enhanced atherosclerosis. [PDF]
PLoS ONE, 2010 Atherosclerosis is a chronic inflammatory disease that evolves from the interaction of activated endothelial cells, macrophages, lymphocytes and modified lipoproteins (LDLs).
Sokrates Stein +6 more
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Epigenetic Modifications of the PGC-1α Promoter during Exercise Induced Expression in Mice. [PDF]
PLoS ONE, 2015 The transcriptional coactivator, PGC-1α, is known for its role in mitochondrial biogenesis. Although originally thought to exist as a single protein isoform, recent studies have identified additional promoters which produce multiple mRNA transcripts. One
Timothy L Lochmann +3 more
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