Results 41 to 50 of about 35,403 (120)

PGC-1α is associated with Schizothorax prenanti myoblast differentiation

Journal of Applied Animal Research, 2018
PGC-1α has been considered as an important mediator of functional capacity of muscle. Our previous study indicated that the mRNA level of PGC-1α increased in muscle during Schizothorax prenanti (S. prenanti) growth.
Yanying Zhao, Ruiwen Li, Yaqiu Lin, Fan Luo   +3 more
doaj   +1 more source

Muscle-specific PGC-1α modulates mitochondrial oxidative stress in aged sarcopenia through regulating Nrf2

Experimental Gerontology
Background: Aged sarcopenia is characterized by loss of skeletal muscle mass and strength, and mitochondrial dysregulation in skeletal myocyte is considered as a major factor.
Lei Song, Jianfeng Xue, Lingfen Xu, Lin Cheng, Yongxia Zhang, Xiaojun Wang   +5 more
doaj   +1 more source

A CRM1 Inhibitor Alleviates Cardiac Hypertrophy and Increases the Nuclear Distribution of NT-PGC-1α in NRVMs

Frontiers in Pharmacology, 2019
Chromosomal maintenance 1 (CRM1) inhibitors display antihypertrophic effects and control protein trafficking between the nucleus and the cytoplasm. PGC-1α (peroxisome proliferator-activated receptor gamma coactivator-1alpha) is a type of transcriptional ...
Zuheng Liu, Zuheng Liu, Haiping Tian, Haiping Tian, Haiping Tian, Jinghai Hua, Jinghai Hua, Wanqiang Cai, Wanqiang Cai, Yujia Bai, Yujia Bai, Qiong Zhan, Qiong Zhan, Wenyan Lai, Wenyan Lai, Qingchun Zeng, Qingchun Zeng, Hao Ren, Hao Ren, Dingli Xu, Dingli Xu   +20 more
doaj   +1 more source

Skeletal muscle PGC-1α is required for maintaining an acute LPS-induced TNFα response. [PDF]

PLoS ONE, 2012
Many lifestyle-related diseases are associated with low-grade inflammation and peroxisome proliferator activated receptor γ coactivator (PGC)-1α has been suggested to be protective against low-grade inflammation.
Jesper Olesen, Signe Larsson, Ninna Iversen, Simi Yousafzai, Ylva Hellsten, Henriette Pilegaard   +5 more
doaj   +1 more source

Omega-3 Fatty Acids Upregulate SIRT1/3, Activate PGC-1α via Deacetylation, and Induce Nrf1 Production in 5/6 Nephrectomy Rat Model

Marine Drugs, 2021
Mitochondrial dysfunction contributes to the pathogenesis of kidney injury related with cardiovascular disease. Peroxisome proliferator-activated receptor gamma coactivator-1 alpha (PGC-1α) protects renal tubular cells by upregulating nuclear factor ...
Sung Hyun Son, Su Mi Lee, Mi Hwa Lee, Young Ki Son, Seong Eun Kim, Won Suk An   +5 more
doaj   +1 more source

PGC-1α induces mitochondrial and myokine transcriptional programs and lipid droplet and glycogen accumulation in cultured human skeletal muscle cells. [PDF]

PLoS ONE, 2012
The transcriptional coactivator peroxisome proliferator-activated receptor-gamma coactivator 1 alpha (PGC-1α) is a chief activator of mitochondrial and metabolic programs and protects against atrophy in skeletal muscle (skm).
Emma Mormeneo, Cecilia Jimenez-Mallebrera, Xavier Palomer, Valeria De Nigris, Manuel Vázquez-Carrera, Anna Orozco, Andrés Nascimento, Jaume Colomer, Carles Lerín, Anna M Gómez-Foix   +9 more
doaj   +1 more source

PGC-1α attenuates hydrogen peroxide-induced apoptotic cell death by upregulating Nrf-2 via GSK3β inactivation mediated by activated p38 in HK-2 Cells

Scientific Reports, 2017
Ischemia/reperfusion injury triggers acute kidney injury (AKI) by aggravating oxidative stress mediated mitochondria dysfunction. The peroxisome proliferator-activated receptor gamma coactivator 1α (PGC-1α) is a master player that regulates mitochondrial
Hoon-In Choi, Hye-Jin Kim, Jung-Sun Park, In-Jin Kim, Eun Hui Bae, Seong Kwon Ma, Soo Wan Kim   +6 more
doaj   +1 more source

αvβ5 Integrin/FAK/PGC-1α Pathway Confers Protective Effects on Retinal Pigment Epithelium. [PDF]

PLoS ONE, 2015
To elucidate the mechanism of the induction of peroxisome proliferator-activated receptor γ coactivator-1α (PGC-1α) by photoreceptor outer segments (POS) and its effects on retinal pigment epithelium (RPE).PGC-1α upregulation by POS was confirmed in ARPE-
Murilo F Roggia, Takashi Ueta
doaj   +1 more source

PPARGC1A regulates transcriptional control of mitochondrial biogenesis in early bovine embryos

Frontiers in Cell and Developmental Biology
Extensive mitochondrial replication during oogenesis and its role in oocyte maturation and fertilization indicate that the amount of mitochondrial DNA (mtDNA) may play a significant role in early embryonic development.
Muhammad Idrees, Muhammad Idrees, Zaheer Haider, Chalani Dilshani Perera, Safeer Ullah, Seo-Hyeon Lee, Seung Eun Lee, Sung-Sik Kang, Sung Woo Kim, Il-Keun Kong, Il-Keun Kong, Il-Keun Kong   +11 more
doaj   +1 more source

PPARγ coactivator-1α (PGC-1α) protects neuroblastoma cells against amyloid-beta (Aβ) induced cell death and neuroinflammation via NF-κB pathway

BMC Neuroscience, 2017
Background Alzheimer’s disease is characterized by the accumulation of amyloid beta (Aβ) and the formation of neurofibrillary tangles. Aβ is the main constituent of senile plaques and is largely involved in neuronal death and neuroinflammation ...
Yuqin Zhang, Changchun Chen, Yanliu Jiang, Shupei Wang, Xiaoyu Wu, Kai Wang   +5 more
doaj   +1 more source