Results 51 to 60 of about 35,403 (120)

Skeletal muscle-specific expression of PGC-1α-b, an exercise-responsive isoform, increases exercise capacity and peak oxygen uptake. [PDF]

PLoS ONE, 2011
Maximal oxygen uptake (VO(2max)) predicts mortality and is associated with endurance performance. Trained subjects have a high VO(2max) due to a high cardiac output and high metabolic capacity of skeletal muscles.
Miki Tadaishi, Shinji Miura, Yuko Kai, Yutaka Kano, Yuichi Oishi, Osamu Ezaki   +5 more
doaj   +1 more source

Suppression of PGC-1α Is Critical for Reprogramming Oxidative Metabolism in Renal Cell Carcinoma

Cell Reports, 2015
Long believed to be a byproduct of malignant transformation, reprogramming of cellular metabolism is now recognized as a driving force in tumorigenesis. In clear cell renal cell carcinoma (ccRCC), frequent activation of HIF signaling induces a metabolic ...
Edward L. LaGory, Colleen Wu, Cullen M. Taniguchi, Chien-Kuang Cornelia Ding, Jen-Tsan Chi, Rie von Eyben, David A. Scott, Adam D. Richardson, Amato J. Giaccia   +8 more
doaj   +1 more source

A20 deubiquitinase controls PGC-1α expression in the adipose tissue

Lipids in Health and Disease, 2018
Background Peroxisome proliferator-activated receptor γ coactivator- 1alpha (PGC-1α) plays an important role in whole body metabolism and, particularly in glucose homeostasis.
Bruna Bombassaro, Leticia M. Ignacio-Souza, Carla E. Nunez, Daniela S. Razolli, Rafael M. Pedro, Andressa Coope, Eliana P. Araujo, Elinton A. Chaim, Licio A. Velloso   +8 more
doaj   +1 more source

Erratum to "Melatonin-Induced PGC-1α Improves Angiogenic Potential of Mesenchymal Stem Cells in Hindlimb Ischemia" [Biomol. Ther. 28 (2020) 240-249]

Biomolecules & Therapeutics, 2021
Lee, Jun Hee, Han, Yong-Seok, Lee, Sang Hun   +2 more
openaire   +3 more sources

PGC-1α-mediated changes in phospholipid profiles of exercise-trained skeletal muscle

Journal of Lipid Research, 2015
Exercise training influences phospholipid fatty acid composition in skeletal muscle and these changes are associated with physiological phenotypes; however, the molecular mechanism of this influence on compositional changes is poorly understood ...
Nanami Senoo, Noriyuki Miyoshi, Naoko Goto-Inoue, Kimiko Minami, Ryoji Yoshimura, Akihito Morita, Naoki Sawada, Junichiro Matsuda, Yoshihiro Ogawa, Mitsutoshi Setou, Yasutomi Kamei, Shinji Miura   +11 more
doaj   +1 more source

Macrophage PPAR gamma Co‐activator‐1 alpha participates in repressing foam cell formation and atherosclerosis in response to conjugated linoleic acid

EMBO Molecular Medicine, 2013
Conjugated linoleic acid (CLA) has the unique property of inducing regression of pre‐established murine atherosclerosis. Understanding the mechanism(s) involved may help identify endogenous pathways that reverse human atherosclerosis.
Cathal McCarthy, Nora T. Lieggi, Denis Barry, Declan Mooney, Monica de Gaetano, William G. James, Sarah McClelland, Mary C. Barry, Laure Escoubet‐Lozach, Andrew C. Li, Christopher K Glass, Desmond J. Fitzgerald, Orina Belton   +12 more
doaj   +1 more source

PGC‐1α overexpression increases transcription factor EB nuclear localization and lysosome abundance in dystrophin‐deficient skeletal muscle

Physiological Reports, 2020
Duchenne muscular dystrophy (DMD) is caused by the absence of functional dystrophin protein and results in progressive muscle wasting. Dystrophin deficiency leads to a host of dysfunctional cellular processes including impaired autophagy.
Hannah R. Spaulding, Amanda K. Ludwig, Katrin Hollinger, Matthew B. Hudson, Joshua T. Selsby   +4 more
doaj   +1 more source

Skeletal muscle‐specific PGC‐1α‐b overexpression prevents eccentric contraction‐induced muscle injury through an utrophin‐independent pathway in mice

Physiological Reports
Slower oxidative fibers are more resistant to eccentric contraction (ECC)‐induced muscle damage than fast‐twitch glycolytic fibers, but the mechanisms remain unclear. This study investigated the roles of the exercise‐inducible PGC‐1α isoform PGC‐1α‐b and
Azuma Naito, Nao Tokuda, Nao Yamauchi, Ayaka Niibori, Kazuma Okada, Koichi Himori, Yuki Ashida, Takashi Yamada   +7 more
doaj   +1 more source

Thyroid Hormone Induces PGC-1α during Dendritic Outgrowth in Mouse Cerebellar Purkinje Cells

Frontiers in Cellular Neuroscience, 2017
Thyroid hormone 3,3′,5-Triiodo-L-thyronine (T3) is essential for proper brain development. Perinatal loss of T3 causes severe growth defects in neurons and glia, including strong inhibition of dendrite formation in Purkinje cells in the cerebellar cortex.
Tetsu Hatsukano, Tetsu Hatsukano, Junko Kurisu, Kansai Fukumitsu, Kansai Fukumitsu, Kazuto Fujishima, Mineko Kengaku, Mineko Kengaku   +7 more
doaj   +1 more source

PGC-1α promotes the survival of newborn neurons within AD hippocampus through activation of the FNDC5/BDNF/TrkB signaling pathway

Frontiers in Molecular Neuroscience
BackgroundThe learning and memory impairments observed in Alzheimer’s disease (AD) are strongly associated with impaired neurogenesis in the hippocampal region.
Yi-Jie Wang, Yi-Jie Wang, Yu-Xin Wang, Yu-Xin Wang, Cheng-Zhi Zou, Wei-Jun Zhang, Wen Pan, Jia-Qing Wang, Hua Wang, Xin Qian, Guo-Jia-Hao Han, Feng-Guo Liu, Jia Wang, Jia Wang   +13 more
doaj   +1 more source