Results 31 to 40 of about 35,403 (120)

Upregulation of PGC-1α Attenuates Oxygen-Glucose Deprivation-Induced Hippocampal Neuronal Injury

Neural Plasticity, 2022
Hippocampal neuronal damage likely underlies cognitive impairment in vascular dementia (VaD). PPARγ coactivator-1α (PGC-1α) is a master regulator of mitochondrial biogenesis.
Bin Han, Hui Zhao, Xingji Gong, Jinping Sun, Song Chi, Tao Liu, Anmu Xie   +6 more
doaj   +1 more source

LncRNA FENDRR Inhibits ox-LDL Induced Mitochondrial Energy Metabolism Disorder in Aortic Endothelial Cells via miR-18a-5p/PGC-1α Signaling Pathway

Frontiers in Endocrinology, 2021
Atherosclerosis (AS) is the main cause of morbidity and mortality in the world. Mitochondrial dysfunction is closely related to AS. At present, several signaling pathways related to mitochondrial dysfunction have been found, one of which is around PGC-1α.
Guiming Wang, Yudong Yang, Honggang Ma, Liuming Shi, Wenbin Jia, Xing Hao, Weizong Liu   +6 more
doaj   +1 more source

PPRC1, but not PGC-1α, levels directly correlate with expression of mitochondrial proteins in human dermal fibroblasts [PDF]

Genetics and Molecular Biology, 2020
The XPC protein, which is mutated in xeroderma pigmentosum (XP) complementation group C (XP-C), is a lesion recognition factor in NER, but it has also been shown to interact with and stimulate DNA glycosylases, to act as transcriptional co-activator and ...
Mateus Prates Mori, Nadja Cristhina de Souza-Pinto   +1 more
doaj   +1 more source

PGC-1α in Disease: Recent Renal Insights into a Versatile Metabolic Regulator

Cells, 2020
Peroxisome proliferator-activated receptor gamma co-activator 1 alpha (PGC-1α) is perhaps best known as a master regulator of mitochondrial biogenesis and function.
Joseph M. Chambers, Rebecca A. Wingert
doaj   +1 more source

PGC-1α and PGC-1β Increase Protein Synthesis via ERRα in C2C12 Myotubes

Frontiers in Physiology, 2018
The transcriptional coactivators peroxisome proliferator-activated receptor-γ coactivator-1α (PGC-1α) and PGC-1β are positive regulators of skeletal muscle mass and energy metabolism; however, whether they influence muscle growth and metabolic ...
Erin L. Brown, Victoria C. Foletta, Craig R. Wright, Patricio V. Sepulveda, Nicky Konstantopoulos, Andrew Sanigorski, Paul Della Gatta, David Cameron-Smith, Anastasia Kralli, Aaron P. Russell   +9 more
doaj   +1 more source

PGC-1α determines light damage susceptibility of the murine retina. [PDF]

PLoS ONE, 2012
The peroxisome proliferator-activated receptor γ coactivator 1 (PGC-1) proteins are key regulators of cellular bioenergetics and are accordingly expressed in tissues with a high energetic demand.
Anna Egger, Marijana Samardzija, Vithiyanjali Sothilingam, Naoyuki Tanimoto, Christina Lange, Silvia Salatino, Lei Fang, Marina Garcia-Garrido, Susanne Beck, Michal J Okoniewski, Albert Neutzner, Mathias W Seeliger, Christian Grimm, Christoph Handschin   +13 more
doaj   +1 more source

Metabolomic Analysis of the Skeletal Muscle of Mice Overexpressing PGC-1α. [PDF]

PLoS ONE, 2015
Peroxisome proliferator-activated receptor (PPAR) γ coactivator 1α (PGC-1α) is a coactivator of various nuclear receptors and other transcription factors whose expression increases in the skeletal muscle during exercise.
Yukino Hatazawa, Nanami Senoo, Miki Tadaishi, Yoshihiro Ogawa, Osamu Ezaki, Yasutomi Kamei, Shinji Miura   +6 more
doaj   +1 more source

Dendrobium officinale polysaccharide ameliorates high-fat diet-induced hepatic lipid metabolic disorder via the SIRT6/PGC-1α signaling axis

Frontiers in Nutrition
Aims This study aims to explore the potential therapeutic effect of Dendrobium officinale polysaccharide (DOP) on non-alcoholic fatty liver disease (NAFLD) induced by high-fat diet (HFD), and to elucidate the underlying mechanism involving the ...
Hu, Binhong, Yao, Ling, Deng, Xin, Zhao, Wei, Chen, Kuo, Zhang, Jiacheng, Li, Zhiqiang, Li, Jin-ping, Jiang, Wei, Liu, Huabao   +9 more
openaire   +2 more sources

Rosiglitazone-induced mitochondrial biogenesis in white adipose tissue is independent of peroxisome proliferator-activated receptor γ coactivator-1α. [PDF]

PLoS ONE, 2011
BackgroundThiazolidinediones, a family of insulin-sensitizing drugs commonly used to treat type 2 diabetes, are thought to exert their effects in part by promoting mitochondrial biogenesis in white adipose tissue through the transcriptional coactivator ...
Rosario Pardo, Natàlia Enguix, Jaime Lasheras, Juan E Feliu, Anastasia Kralli, Josep A Villena   +5 more
doaj   +1 more source

Chronic caloric restriction attenuates a loss of sulfatide content in PGC-1α mouse cortex: a potential lipidomic role of PGC-1α in neurodegeneration

Journal of Lipid Research, 2012
Peroxisome proliferator-activated receptor gamma coactivator-1α (PGC-1α), a key regulator of energy metabolism and lipid homeostasis in multiple highly oxidative tissues, has been implicated in the metabolic derangements of diabetes and obesity. However,
Michael A. Kiebish, Dee M. Young, John J. Lehman, Xianlin Han   +3 more
doaj   +1 more source